Combinations - Cross tolerance between mescaline and LSD?

[ComfortablyNumb]

SWIM was wondering if there is any cross tolerance between these two. SWIM isnt sure if the two drugs need to be chemically similar for them to have a cross tolerance or wether it if they have similar effects. SWIM was think about doing LSD tomorrow, and maybe mescaline on sunday. Would the mescaline be wasted, less potent or dull? Because both substances are so powerful, SWIM probably wont be doing LSD tommorow, so reall ySWIM was wondering how long after the mescaline would have to wait to have his LSD trip. SWIM would probably wait at least two weeks before tripping, would the LSD still be as strong as it should be?

[chillinwill]

There are definitely cross tolerance issues with these two drugs due to both of them binding and activating the 5-HT2A and other 5-HT receptors. Wait at least a week in between trips so that the trip won't be diminished.

[PsychedeliaSmith]

There is a cross tolerance between LSD, magic mushrooms and mescaline.
Like it has already been said, try to wait atleast a week between trips to get the most out of them.