Combinations - Rue and Piracetam

[Felix Guattari]

SWiM should be receiving his order of HBWR seeds sometime later this week and, while he finds LSAs to be pleasant by themselves, he prefers to combine them with either an MAO-A inhibitor or some piracetam and has experience with both (the rue only in lower doses as not to provoke a painful body load, the possibility for which is already present with HBWR) as woodrose admixtures.

What I'm pondering now is the possibility of adverse effects due to the interaction of rue and the piracetam. It seems I've heard not to combine these two, but a) I can't think of any especially convincing reason why this might be the case and b) I can't seem to find any experiences that would seem to support this.

Anyone have any experience here?

[Potter]

You say MAOI-A but rue is a B inhibitor and as far as nobody knows no one uses the A's in combination with the stuff that goes on here, since they are all long acting. Did you make a mistake here or are you on to something new?

As far as finding info on non-standard MAOI combinations, good luck, been hunting for stuff too and there's very little in the field. With the severity of negative reactions with the inhibitors, there's not a lot of motivation for people to be experimenting.

Even though Piracetam is pretty benign in effects, so is hard cheese, chocolate, grapefruit and all those other foods that are counter indicated, so it could be a crap shoot.

There SHOULD be some way to model the interactions if one knew enough about the pathways involved in the brain, but nobody's no neurologist.

Best of luck

[Felix Guattari]

The actives in P. harmala are harmaline, harmine and tetrahydroharmine. Harmine and harmaline are, like moclobemide, RIMAs - reversible inhibitors of monoamine oxidase (explained on wiki and here). Some say tetrahydroharmine has SSRI action, but it could have some affinity for 5-HT as an agonist as well. I myself am not 100% sure about THH, as the literature is scarce.