Opinions - Lisdexamfetamine + Fluoxetine + Advice

[wespawloski]

SWIM has a prescription for 30 mgs Vyvanse and has recently been dealing with comedown issues. He is now experimenting with 150 - 210mg + which provides benefits for six hours+ unlike 30-90 which causes him to crash in 2-3 hours and hurts his school day.

He is taking Vyvanse for continual depression, concentration, sensory lag, lack of feeling etc. He has been prescribed Escitalopram(Lexapro), Fluoxetine, Bupropion, and Atomoxetine which he has found all of them to be completely useless, notably in the case of Strattera after four weeks+ he still was getting a tired effect and a 4x dose made him really really tired.

SRIs seem to have little to no effect on SWIM after a month of use, but he is curious that perhaps in conjunction with Vyvanse, Prozac might prove ultimately beneficial. He does not want to go down a line of pushing prozac needlessly if it will make him semi-tired and provide no benefit while diminishing his hunger; he is in an experimenting mood with St. Johns, 5-HTP, and his amphetamine dose and has no idea whether to bother with prozac.

Also Vyvanse is proving very calm and ... weak compared to SWIM's previous street methamphetamine pill experiences. He doesnt mind not having a euphoria, but feels more that he is missing out on a delicious part of amphetamines which could possibly open another door to improving his life. SWIM's psichiatrist is on vacation atm and he is trying to figure out a gameplan to discuss, and is thinking about trying a different stimulant. Suggestions in SWIM's case? He is not looking to get high, just to overcome issues of anxiety and concentration; Vyvanse being his first pharmacutical he has no idea what to expect, but being only decently fulfilled at 210 mgs he feels Vyvanse may not be right for him and does not like the idea of pumping that much amphetamine into his body daily.

[fiveleggedrat]

First off:

taking Vyvanse for continual depression, concentration, sensory lag, lack of feeling etc

What? Why are you taking an amphetamine for depression?! That sounds utterly retarded of a doctor to prescribe. Were you ever designated ADD or ADHD?

If you want concentration, modafinal or adrafinal are better choices. So are nootropics like piracetam.

Mixing Prozac with amphetamines sounds like a bad idea. Do not both of them play on serotonin? Is this not a risk of Serotonin Syndrome?

If SSRI's aren't helping, talk to your doctor!

St. Johns, 5-HTP, and his amphetamine dose and has no idea whether to bother with prozac.

WHAT ARE YOU DOING?! You CANNOT combine those! 5tp increases serotonin. St Johns interacts with it, as well as prozac and amphetamine! STOP MIXING! DANGEROUS! Risk of seizure and serotonin syndrome! Jesus, what kind of doctor are you SEEING?!


You want my opinion? Get off those drugs. Get of all of it. I see no information describing a serious need for them. You should only be taking the amphetamine IF you are ADD/ADHD and it helps you. Otherwise, you are just abusing the drug and do not need it. If you need something for focus, look up nootropics. A lot better than a physical addiction to amphetamines and a fucked up mesolimbic pathway.

You do not need to make the prozac "better". If it's not working, get off the stuff. It evidently is not helping if you have to take amphetamines on top.

You sound like you are heading down a dangerous path, and for many reasons.

[wespawloski]

SWIM is respecting of your concern, but feels his grasp on brain chemistry is sufficient to protect himself. SWIM is in no way looking to get high and acts responsibly based on research.

SWIM has not been diagnosed with anything, but he feels he would know if he was depressed. Also SWIM very much suspects he has something along the lines of mild Asperger syndrome, which he feels blessed his psichiatrist had previously dealt with and Vyvanse was the only thing that worked for them. SWIM feels confident with his theories and plans to major in psychology and work with pharmacology as a sub. Anyway...

SWIM is very much aware of serotonin syndrome and does not believe with proper modification of afore mentioned doses he is in no danger. He has experienced extreme methamphetamine euphorias (sometimes with some 5-HTP backing) where his poor serotonin levels were probably stretched more than anything recently. At this point he feels a need to use 5-HTP and St. Johns if he wants to be productive at all during the latter day period as the crashes he experiences hamper his activity (interestingly enough in a 60mg experiment, after his crash in the evening portion of the day 60mg again only barely elevated him to a normal level ++).

5-HTP floods the system with serotonin, St. J acts as a reuptake inhibitor. In combination, SWIM has found it to be a nice little stimulation for a couple of hours. He doesnt bother to use St. during amphetamine provocation because he has a notion it will compete and lessen activity.

amphetamine induces stimulation by interacting with neurotransmitter sites (SWIM read Dextroam. is 1:1 N and 1:10 N:H). SWIM believes there is a kink in his pathways causing understimulation, which is why he would even resort to amphetamine. So possibly the workings of a SSRI and amphetamine combo would stimulate some lapse sites proactively; he is somewhat weary about all the extra serotonin hence the consultation.

Concentration is only a symptom to SWIM, his main problem resides in his feelings of constant inhibition. Sadly SWIM has access to a 'abnormal psychology' book and thus finds many things at fault with himself and his sense, pointing to an anxiety and depression mix :/ a good example being his variable views on his looks depending on how down he is. He feels something is wrong. But it could all just be in his head