Other - What to make of Morphine

[JohnnyTightLips]

Alright, so here's the deal:

SWIM has extracted morphine from a bunch of poppy pods, in the form of morphine sulfate. SWIM tried an actual MS Contin pill the other day and said his chest felt real heavy, it was a 30mg dose, 2/3s of which he snorted, and the other 1/3 he ate (all at the same time). SWIM's tolerance is not very developed (and likes to keep it that way....20mg of OC is good for him for example). Anyways, back to the point, it wasn't a very euphoric high for SWIM, he was quite uncomfortable throughout the whole thing because of the heavy chest.

Now, SWIM would prefer to snort the goodies, so that's what he tried when he first refined his morphine, but soon discovered through testing and through these forums that morphine is only about 10% bioavailable through insufflation. What SWIM wants to know is can he chemically convert the morphine into either oxymorphone, hydromorphone, dihydromorphone, or something similar in order to achieve these goals:

1. bioavailability of intranasal decent (40% or better maybe?)
2. not as heavy on the chest (quite uncomfortable, anyone else have that problem?)
3. decent euphoria or course!

SWIM is fairly competent 'in the lab' but would certainly prefer a simple process for refinement, common reagants, etc.

Any thoughts, ideas, suggestions, etc. would definitely be appreciated, thanks!

[ironmics]

The only simple synths are for 6MA Morphine and Heroin, but I've also seen one for dihydro. 6MA is just morphine + acetic acid, so that's the easiest for sure.

[Oneiros]

I believe Morphine in GAA with Pd/C as a catalyst would yield dihydromorphine.
From there, Dihydromorphine + Kt-BuO would yield hydromorphone.

I think that getting that 14-hydroxy in there would be a pain in the ass and probably not worth your time.

If you're extracting pods, why not extract the thebaine as well as the morphine? Having that thebaine on hand would open up all kinds of routes...

Reputation Comments on this post:

Thanks for the PM help!

[thestranger]

Originally Posted by Oneiros

I believe Morphine in GAA with Pd/C as a catalyst would yield dihydromorphine.
From there, Dihydromorphine + Kt-BuO would yield hydromorphone.

I think that getting that 14-hydroxy in there would be a pain in the ass and probably not worth your time.

If you're extracting pods, why not extract the thebaine as well as the morphine? Having that thebaine on hand would open up all kinds of routes...

I dont know how to extract thebaine, but extracting Morphine is very very easy, as all you have to do is add Lime (calcium oxide), and it causes the morphine to the top....

[davestate]

Originally Posted by Oneiros

I believe Morphine in GAA with Pd/C as a catalyst would yield dihydromorphine.
From there, Dihydromorphine + Kt-BuO would yield hydromorphone.

I think that getting that 14-hydroxy in there would be a pain in the ass and probably not worth your time.

If you're extracting pods, why not extract the thebaine as well as the morphine? Having that thebaine on hand would open up all kinds of routes...

Unfortunately for most mere mortals Palladium black is near unobtainable and very expensive. SWIM is on the verge of obtaining some, which opens up some very interesting synth pathways, think Hydrocodone from codeine phosphate with nothing more than phosphoric acid, Pd/C and reflux.

The same applies for Morphine

5 grams morphine was dissolved in 50 ml of alcohol and after the addition of 0.5g of palladium black, the mixture was refluxed for 4 hours. After the catalyst was filtered off and the solution concentrated, dihydromorphinone crystallized. Yield 3 grams.