A Randomized, Open-Label, Controlled Trial of Gabapentin and Phenobarbital in the Treatment of Alcohol Withdrawal (Mariani et al 2006)

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A new entry has been added to Drugs Archive by Thirdeyefloond
Description:
The American Journal on Addictions, 15: 76–84, 2006

John J. Mariani, Richard N. Rosenthal, Susan Tross, Prameet
Singh, Om P. Anand

Gabapentin was compared with phenobarbital for the
treatment of alcohol withdrawal in a randomized, openlabel,
controlled trial in 27 inpatients. There were no significant
differences in the proportion of treatment completers
between treatment groups or the proportion of patients in
each group requiring rescue medication for breakthrough
signs and symptoms of alcohol withdrawal. There were no
significant treatment differences in withdrawal symptoms
or psychological distress, nor were there serious adverse
events. These findings suggest that gabapentin may be as
effective as phenobarbital in the treatment of alcohol withdrawal.
Given gabapentin’s favorable pharmacokinetic profile,
further study of its effectiveness in treating alcohol
withdrawal is warranted

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