The pharmacokinetics of oxycodone after intravenous injection in adults (1991)

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British Journal of Pharmacology 1991 Oct;32(4):516-8

Pöyhiä R, Olkkola KT, Seppälä T, Kalso E.

Oxycodone chloride (0.07 mg kg-1) was given by intravenous bolus to nine young adult surgical patients on the first postoperative day. Plasma was sampled for up to 12 h. Mean values of t1/2z, CL and Vss were 222 min, 0.78 l min-1 and 2.60 l kg-1, respectively. The concentrations of the metabolite noroxycodone was also measured. The mean AUC(0,12) ratio of noroxycodone to oxycodone was 0.33. Oxymorphone was not detected.

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