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Nightshades Atropine plants like Datura(Angel trumpet), Mandrake & Bella Donna

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Old 10-03-2008, 00:35
cosmicruler cosmicruler is offline
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Solanum mauritianum(Woolly nightshade) and steroid Solasodine??

Has any1 got any information on the steroid Solasodine and what it is used for???it is prevalent in Woolly nightshade and has been shown in some studys to have some cancer fighting properties but that is all ive been able to find thus far...also if any1 has access to a paper on how to extract the alkoloid it woukld be appreciated..thank in advance and ive already UTFSE.!
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Old 10-03-2008, 00:37
cosmicruler cosmicruler is offline
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Re: Solanum mauritianum(Woolly nightshade) and steroid Solasodine??

"A simple extraction and isolation process of solasodine, a natural precursor to synthesize steroidal drugs, from fruits and leaves of Solanum laciniatum Ait. was developed. The optimum concentration of 2-propanol for the extraction of crude glycosides was 70%. The suitable hydrolysis condition of solasodine from crude glycosides was by 1 N hydrochloric acid in 2-propanol. Pure solasodine from both fruits and leaves of Solanum laciniatum Ait. was obtained without any requirement of column chromatography. The yield of pure solasodine were 0.340.04% and 0.440.16% of the dry weight of fruits and leaves, respectively. The maximum yield of 37.0% of pure 16-DPA was obtained by using tetrabutylammonium hydrogen sulfate as a phase-transfer catalyst and potassium dichromate as an oxidizing agent. The results indicated the novel economic with environmental friendly method of solasodine extraction and synthesis of 16-dehydropregnenolone acetate from solasodine by phase-transfer catalysis. "


i just found this and i think it has a full synth attached...but any other info is appreciated!!!
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