Pharmacology - Transient reinforcing effects of phenylisopropylamine and indolealkylamine hallucinogens in rhesus monkeys (2004)

[Jatelka]

A new entry has been added to Drugs Archive

Description:
Behav Pharmacol. 2004 Mar;15(2):149-57

Fantegrossi WE, Woods JH, Winger G.

Relatively few studies have assessed the reinforcing effects of hallucinogenic compounds, and no such studies have attempted to engender contingent responding for these compounds in animals with behavioral histories that include experience with serotonergically mediated reinforcing effects. The objectives of the present study were to investigate the capacity of several hallucinogenic compounds to maintain self-administration behavior in rhesus monkeys with a previous history of 3,4-methylenedioxymethamphetamine (MDMA) self-administration, and to compare these effects across a range of doses of drugs from two structural classes (indolealkylamines and phenylisopropylamines). The results indicate that no compound generated reliable responding and that no subject ever self-administered 4-iodo-2,5-dimethoxyphenylisopropylamine (DOI) at rates above those engendered by contingent saline. However, 3 out of 4 subjects did respond at rates between 0.75 and 3.0 responses/s in one or more sessions where N,N-dimethyltryptamine (DMT), mescaline or psilocybin were available. During some of these sessions in which self-administration was maintained, animals earned a majority of all available infusions and appeared intoxicated by the end of the session. This pattern of transient self-administration may indicate that these compounds have weak reinforcing effects, or mixed reinforcing and aversive effects.

To check it out, rate it or add comments, visit Transient reinforcing effects of phenylisopropylamine and indolealkylamine hallucinogens in rhesus monkeys (2004)
The comments you make there will appear in the posts below.

[nanobrain]

fascinating in re DMT..

[snapper]

What is unclear is the dosing. Smaller doses of LSD, mescaline and even DMT are more akin to speed and are not overwhelming. The comment that :
"During some of these sessions in which self-administration was maintained, animals earned a majority of all available infusions and appeared intoxicated by the end of the session."
insinuates that they needed to dose small amounts frequently to become "intoxicated". If the monkeys were to receive a large dose at one time, perhaps they would not reinforce. Since DMT is short acting, it would be most likely to trigger reinforcing behavior, and DOI (good god!) the least likely. Pretty useless study in SWIM's opinion, and not a nice thing to do to monkeys.

[Ryu]

Seems to be a rather weak and flawed study, Discard chemistry & lets see what happens to the doper monkeys kind of attitude?