Paraphernalia - Tramadol vs. O-desmethyltramadol (repeated dosing)

[Paracelsus]

I have often read online (on this forum and in other places) that repeated dosing makes tramadol better because it allows tramadol to clear while the desired metabolite O-desmethyltramadol builds up in the bloodstream.

I started this thread to find out if there is any evidence that this is true and proven. I have only seen concentration/time diagrams for tramadol alone and not O-desmethyltramadol. If anyone has access to details on tramadol and O-dmt pharmacokinetics which indicate that this is plausible, please share. Concentration-time diagrams for both tramadol and O-dmt which show concentrations following repeated dosing would also be useful.

If this would be true, timed-release tramadol (Ultram ER and the like) would have a higher abuse potential than instant-release tramadol.

[Ethyl]

I have seen graphs that show that repeated dosing increases leves of m1. i'll try to find

as for the abuse potential of ir vs er. ir is better, cause it causes more activity in the liver, and the bood is more rapidly flooded with tram/m1.

but as numbers/facts m1 is greater in porportion when sr is used looking into m1 and tramadol concentration.

everytime you take a dose of ir is at least 50/100mg that arrive in there.. with er that would be over hours and even if it has more m1, the time that took to get to that point is to long for obtaining much euphoria.
i ussually take 50/100mg every 30/60min.

[Ethyl]

look at this part of this document:

Table III. Pharmacokinetic properties of M1 and tramadol after administration of tramadol

http://www.drugs-forum.com/forum/loc...1613&catid=106

[fiveleggedrat]

Swim knows this is an old thread, but tramadol has been his most experimented with substance, and swim has always been interested in the whole o-desmethyl thing.

Swim will set up an experiment with repeated dosing, but Swim is really interested in dosing longer than a 6 hour period. Swim doses throughtout no more than 3-4 hours. Swim limits himself to, on average, 300mg tramadol, and finds any more to be a waste.