Paraphernalia - New legal endorphin analgesics; metkephamid and actinonin!

[Handle]

Hey, good news from the endogenous front, there are two new substances with great potential in terms of euphoria, analgesia and warm glowing warming glow, and at the moment they are totally legal!

The first is metkephamid. The trouble so far with opioid peptides is that they are not systemicallyally acting. What's that mean? You can't snort it, smoke it, shoot it up, and you certainly can't swallow it. This is because they are delicate protein like materials which #1 are too big to cross the blood brain barrier and #2 they are quickly degraded in the body. They are only active via nasty stuff like epidural, intrathecal and cerebroventricular injection [Drilling a bur hole in the skull and slamming the sweet sweet endorphins DIRECTLY INTO THE BRAIN!] Well, it's pretty clear most people wouldn't want that, and wouldn't be qualified even if they did.
For a long time this has rendered endogenous peptides like beta endorphins and endomorphins as mere medical playthings among researchers able to carry out the difficult and dangerous act of administering the peptides by the aforementioned methods.
But now, there is metkephamid, an analog of methionine enkephalin, centrally acting, powerful analgesic agent, so stable and effective they have even done non injection trials [ie, where the sun don't shine], but it certainly works when slammed. The best part is it is not an analog of any existing drug, it is a peptide, and therefore completely legal. Many times more powerful than morphine, it nevertheless is thought to act mainly on the kappa receptor rather than the mu, effecting antinociception via a relatively unstudied pathway. It needs urgent research.

Second, is an interesting new drug with a lot of promise, especially for the opiate naive.
Actinonin [3-((1-((2-[Hydroxymethyl]-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamoyl)octanohydroxamic acid] chemical name stolen from site of A. G. Scientific
is a substance that prevents or delays the degradation of of pentapeptides in the brain, and this way boosts the levels of endogenous opioid peptides, effecting analgesia and euphoria!
Unfortunately addiction potential is similar to actual opiates, as the surplus of endogenous opioids triggers a decline in their production. On the bright side, the pleasurable effects are the result of the action of natural substances, so that the decrease in production will only reflect the increased levels of natural peptides, rather than their replacement by outside chemicals. The advantage of this is that the immune and anti cancer properties of natural lipotropins/endorphins.
Actinonin actually has powerful antibacterial and anti cancer effects, so this could well be due to the natural properties of the peptides that are boosted by it. Again, it is systemically active.

[JaWill88]

has swiy done either of these? and how would one get a hold of these? swims not asking for a specific source or anything, just wondering if it would be in a pharmacy or a research chemical or what?

[Ethyl]

Actinonin looks like the srsi of opiates. Insteresting.

[imyourlittlebare]

Second, is an interesting new drug with a lot of promise, especially for the opiate naive.
Actinonin [3-((1-((2-[Hydroxymethyl]-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamoyl)octanohydroxamic acid] chemical name stolen from site of A. G. Scientific
is a substance that prevents or delays the degradation of of pentapeptides in the brain, and this way boosts the levels of endogenous opioid peptides, effecting analgesia and euphoria!
Unfortunately addiction potential is similar to actual opiates, as the surplus of endogenous opioids triggers a decline in their production. On the bright side, the pleasurable effects are the result of the action of natural substances, so that the decrease in production will only reflect the increased levels of natural peptides, rather than their replacement by outside chemicals. The advantage of this is that the immune and anti cancer properties of natural lipotropins/endorphins.
Actinonin actually has powerful antibacterial and anti cancer effects, so this could well be due to the natural properties of the peptides that are boosted by it. Again, it is systemically active


So this is endogenous? If it is its probably the stuff that is released only in the most extreme cases like someone having to cut off their arm to survive or running away from a lion. If it is endogenous, I dont know how good recreational use would be. There would be some kind of enzyme to break it down and reuptake it. This is probably due to negative secondary systems this effects. The body is a wonderland like john mayer said. This is why certain drugs cause decreases in receptors and brain damage, its because its not naturally whats supposed to happen or its the process on speed. It may negatively effect the whole system by increasing this enzyme, decreasing MU receptors and affinity or possibly worse. Ill try and get up some research on it to see if im right.,

Reputation Comments on this post:

nice post!

[Ethyl]

It wont have any rush to it most certainly..

In medical uses the big difference as said is the imune system. External Opiates lower your imune system response, and internal opiates (endorphins) increase your imune system response. That can make a big difference between life and death.

[Handle]

Hmm, all good comments. I will just say, that I think both of them are artificial. Certainly actinonin I do not think is endogenous, and metkephamid is similar to met enkephalin, which is natural endogenous, but metkeph has been altered slightly [because almost none of the natural endorphins are very effective systemically] but I named this thread as is because they both relate directly to endorphins.

As for actinonin having no rush, I would agree 100%. It would be pointless injecting it [unless to make efficient use of small amounts]. From reports it can induce true analgesic, euphoric experience, but since it is not a psychoactive itself, I would say that there would be a lag while the endorphins form and are not burnt up.

The comment about "ssri" is basically correct, except instead of it having a "tonic effect" over a long time, it would be more of one evening of effects, like an MAOI.

As I said in the first post, it would unfortunately have the same addiction profile as any other opiate, meaning simply the more you take of either one the more your body will either chew it up [like destroy the metkephamid and everything else] or respond by releasing less endorphins [to counteract the overload that actinonin may produce].

As Ethyl said, the only benefit with actinonin is that at least the addiction pattern would be based around your own endorphins being the source of the euphoria, so while you may get addicted and fewer will be released, at least it is due to a surplus of them and not due to them being replaced by an opiate that serves none of the good immune boosting purpose of your own endorphins. So you would be addicting yourself to your own good things, yes it would be a vicious cycle, but in this case the dope's doing you good, instead of usurping endorphins with heroin you'd be just making smaller amounts which last longer. Nevertheless, maybe your body needs to make and break a lot to stay healthy, maybe your pleasure centres would be pleased by the new arrangement, but your immune system would still suffer. Who knows?


I also thought of this when deciding to lump them in the same thread. The body speedily destroys any opioid peptides, whether from within or from without. So a great combo would be, taking metkephamid and actinonin together, then you get high on your own endorphins and the actinonin, [thus giving it a chance to go to work on them old receptors before the peptidases kill it off]

And you could boost actinonin even more by taking skullcap with it, because skullcap has been proven to BOOST THE RELEASE of endorphins, so that would be like taking speed and coke at the same time, speed would flood the dopamine, and coke prevents it getting reabsorbed.
You might develop a new condition known as "endorphin syndrome", except with the new syndrome you die of pleasure!

[0utrider]

well, any further info on that?