im not sure if something like this has been posted before but what the hell swim did a hell lot of research so he will be posting either way. Ill do it in a form of FAQ or smt.
Aright, here goes
Q: why do we administer cocaine by insufflation
A: the mucus membrane of our nose consists of blood rich epithelial tissue. Any small lipophilic molecule can penetrate the epithelials and absorbed rapidly to the blood stream. It is thus a very pottent way of reaching high drug blood plasma levels rapidly.
Q: So any drug can be used like that? Why specifically cocaine?
A: Actually no, not any drug. Our nose is knows that it cant let any particle reach those tender epithelial. It thus secretes mucus (a water based mixture) to protect them. Any substance that enters the nose gets trapped in the mucus. BUT if the substance is water soluble it will get dissolved in the mucus eventually reach the epithelial s and get in the blood stream.
Q: So how do we get cocaine to be water soluble?
A: Water is a polar solvent, as a rule of thumb polar solvents dissolve polar compounds, cocaine base is...well a base i.e. it has a ph of over 7 (7.2 to be precise), you can react it with an acid to form a salt, and salts are polar and thus water soluble. The cocaine hydrochloride salt is exceptionally soluble in water, just 0.5ml of water can dissolve 1gr of cocaine.
Q: so why does the damage happen to the nose?
A: there are several reasons actually. For starters there are the cuts, crapy substances of unknown qualities that can actually mechanically damage the tender mucus membrane. Even if cocaine is fairly pure due to rushed manufacturing excess hydrochloric acid can remain trapped in the cocaine hydrochloride crystals. The acid is corrosive and damages the nose membranes. More over some of the hydrochloride that is in salt form in the cocaine molecule will react with free water protons to form hydrochloric acid. Finally cocaine is a both an anesthetic and a potent vasoconstrictor.
Q: So all these facts affects my flamingos nose
A: The corosion due to HCL acid formation, the mechanical and chemical damage from adulterants, the hypoxia due to vasoconstriction and the fact that due to anesthasia pain cant be felt when cleaning the nose (by hand or whatever) are combined to damage the mucus membranes. Chronic abuse WILL cause ulcerations and finaly a deviated nose septum.
Q: doesnt it heal?
A: Actually it does, our body is very clever, smell is of paramount importance in the survival of any mammal so the nose epithelial s are one of the very few type of epithelial s that can be repaired. The nose mucus membrane is cluttered with stem cells that can become epithylials to repair a small amount of damage. But the repair pottential is very limited, using cocaine to often too much will exceed the body's ability to form new mucus membrane. Even so the number of stem cells is finite, and damage to the nose ocures not only by cocaine but by infections, air particles, scratces caused by hardened mucus (bugers

), fingers, etc etc. Cocaine use definately doesnt help.
Q: Yeah but my flamingo likes cocaine, can i do anything to help?
A: There are several methods beside complete abstinence actually:
* Always perform an acetone wash to your cocaine, this will remove some adulterants and will definitely rid of any excess acid that is trapped by a rushed proses at the manufacturing point
* Do not use cocaine TOO frequently, or too much, the benefits of that are numerous besides letting your body to properly heal your nose before damaging it again. Using cocaine to frequently is like scratching an open wound. Once in a while abstain completely for more than 3-4 weeks also.
* After the end of a cocaine session use a weak saline solution to clean your nose. I.e dissolve a level teaspoon of table salt in a glass of warm water. Then inhale just a little spray of that water. Not much is needed, dont go crazy with that
* Buy some vitamin E capsules, puncture them and drip the vit E oil on your little finger or a cotton ear cue. VERY GENTLY cover the inside of your nose with the oil. Remember cocaine is an anesthetic, you wont be able to properly gauge pain after cocaine use and you might scratch your nose.
* Crash up some tomato and ad some of the juice to your nose. It has some pottent anti oxidants as well
Hope that helps
