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Old 06-10-2007, 03:21
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Codeine and Glutethimide

Hi Peeps,

It was recently brought to my attention that a hypnotic sedative by the name'glutethimide' can be used to potentiate codeine. According to Wikipedia 'glutethimide is an enzyme-inducer. When taken with codeine, it enables the body to convert higher amounts of the codeine (higher than the average 5 - 10%) in to morphine.' and apparently 'in 1991 it was upgraded to Schedule II, more than a decade after recreational abusers discovered that combining the drug with codeine produced a euphoria which closely resembles that obtained from heroin.'

Does anybody know of somebody who has experience with Glutethimide? Swit is very, very intrigued!

Last edited by Tortoise; 06-10-2007 at 07:12. Reason: First sentence had been accidentally chopped short
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Old 06-10-2007, 07:00
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Re: Codeine and Glutethimide

Hey, thanks for starting this tortoise! The only legitimate contributions I can make to this is that the combo, as said on Wikipedia and elsewhere is called 'Fours and Dors' [coming from the old brand name Doriden] and also pancakes and syrup, because the codeine was often in the form of cough syrup. The pills were made by Ciba, and because that was written on them, some people called them 'cibas'. Anyone interested in how it used to be made, or anyone who knows anything, please get some answers happening. Glutethimide bears a structural resemblance to metharbital, but is said to be a derivative of glutaric acid, not glutamic acid. Oddly it is also known as a piperidione, or as Alexander Shulgin calls its group "piperidione barbiturate analogs" because of their close similarity to barbs [a lot of this can actually be found in Shulgin's 'Future Drugs of Abuse' thing, and apologies for not admitting my blatant plagiarism before].
Finally there are thoughts that some tiny use may remain in geriatric medicine, if it is all banned in the west, some Slavic countries still use small amounts.
So, who can elaborate? What is glutaric acid. Phenobarbitone tablets are still pretty easy to obtain as an old fashioned anti epileptic, how hard would it be to swap around and get rid of all the bits and pieces hanging off it and get glutethimide [as seen here, my credentials as a chemist are impeccable], and finally what about this piperidione thing, who knows anything about that? Is that related to piperidine? [That would be funny, because Shulgin points out that glutethimide could be the starting point for a whole line of stimulants!]
And yes, more to the point, is there anyone out there who can remember this stuff, or the combination with codeine? How did it feel?
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