Drug info - Pharmacokinetics and Pharmacodynamics of GHBDuring Tolerance in Rats: Effects of Extr

**Jatelka** · #1 20-06-2007, 20:02

A new entry has been added to Drugs Archive

Description: Originally published in JPET

Looks at the changes in GHB pharmacokinetics that occur with tolerance (which was achieved by day 5). The study concluded that changes in pharmacokinetics were NOT responsible for behavioural tolerance, but that this was due to changes in neurotransmitter responsiveness

To check it out, rate it or add comments, visit Pharmacokinetics and Pharmacodynamics of GHBDuring Tolerance in Rats: Effects of Extracellular Dopamine (Raybon and Boje, 2006)
The comments you make there will appear in the posts below.

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