mixxing opiates

[Laudaphun]

SWIM has been wondering about mixxing different types of opiates at the same time. First off, in the past when SWIM has taken say x3 5mg oxycodone pills along x3 10mg hydrocodone pills, the effect didn't seem as enjoyable as taking x6 of each alone. SWIM is using that as an example only to generalize his past experiences.

Buprenorphine is commonly known to cause withdrawl if taken incorrectly by competing with opiates already in a persons body:

"If there are high levels of another opioid in the body, Suboxone will, in a sense, compete with the other opioid molecules, and knock them off the receptors. This occurs because buprenorphine has an extremely high binding affinity for the opioid receptors. If this happens, the patient will be thrown into precipitated withdrawal, which is extremely unpleasant, and can last a significant period of time."

SWIM has heard horror stories, especially from people trying to switch from methadone to buprenorphine and not waiting long enough to begin the buprenorphine.

SWIMs question is that shouldn't this also be true with other opiates and to varied degrees depending upon which particular opiates are mixxed and their different levels of affinity for each of the opiod receptors? Surely it's not only buperenorphine that competes with other opiates with receptors. SWIM realizes that the reason for the withdrawl reaction caused by buprenorphine is due to the fact that it is a partial agonist rather than a full agonist. Bascially SWIM is wondering whether there could not necessarily be a withdrawl reaction, but a loss in efficiency from mixxing different opiates that have similar receptor binding patterns. Any comments?

SWIM wants to study more about opiod receptors in the brain when he gets some time away from is regular schoolwork.

Reputation Comments on this post:

Educational

[MrJim]

SWIM has heard of this - Just not really heard it to the pont of verification, yet. Would love to know more. He has heard, essentially, that codiene actually "gets in the way" of a more potent opiate when taken before.

[Ethyl]

Originally Posted by MrJim

SWIM has heard of this - Just not really heard it to the pont of verification, yet. Would love to know more. He has heard, essentially, that codiene actually "gets in the way" of a more potent opiate when taken before.

Kappa agonist can be dysphoric and that can lessen the mu agonism euphoria. Maybe it's because of that.

[Ethyl]

Another possibility is codeine bind to the receptor and because it's there the more potent opiate connot bind there.