Nitrous to Potentiate Opiates

[pankreeas]

Swim has been toying with an idea after doing some reading.

The one particular phrase that caught his attention was

"N2O seems to induce its effects through antagonism on NMDA receptors, GABA-A receptor potentiation and potassium channel activation, as well as having a benzodiazepine-like effect and stimulating endogenous opioid receptors."


http://cat.inist.fr/?aModele=afficheN&cpsidt=3778179

is also another link that caught his attention.

So he took 100 mg dxm to smooth out the playing field for the 300mg codeine taken shortly thereafter.
- Did 7 cartridges of nitrous over the next hour and then spaced the rest out throughout the night. He was impressed with the outcome. The shift from nitrous space to opiate land was off the wall. The intensity was definetly amplified for the entire duration of the evening.

swim feels this is worth looking into a little deeper.

[thealexcometh]

am I mistaken in thinking that nitrous is extremely damaging to your brain for very (very very) short and mediocre numbness effects?

[Schwag]

Originally Posted by thealexcometh

am I mistaken in thinking that nitrous is extremely damaging to your brain for very (very very) short and mediocre numbness effects?

It's actually farely safe if you're responsible with it, read this from the erowid section on Nitrous Oxide health:

Nitrous oxide has been safely used as a mild anesthetic for over 150 years. Problems with its use come primarily from carelessness. Potential problems include:

Brain injury and suffocation can result from lack of oxygen. When used as an anesthetic, nitrous is always administered in combination with oxygen. Never use nitrous in any manner that does not provide for adequate oxygen intake.

Note that it is not necessary to feel shortness of breath or a sense of oxygen deprivation in order for the body to be dangerously short of oxygen. The sensation of being unable to breathe comes as a result of unusually high levels of carbon dioxide (CO2) rather than low levels of oxygen. Because of this, people who inhale pure nitrous oxide or other gases do not have the sensation of being unable to breathe, despite not getting enough (or any) oxygen. It is quite possible to suffocate while breathing pure nitrous oxide without ever feeling discomfort or a shortness of breath.

Never strap a gas mask to your face while using pure nitrous as it is possible to black out and die from lack of oxygen.
Never use a garbage bag as a delivery device. It is possible (and has happened) to black out and suffocate when the bag falls over the nose and mouth.
Never open a tank of nitrous in a sealed room, closet, car, or other space.

Very cold temperatures of the gas can freeze the lips and throat if taken directly from a tank or whippit. Releasing the gas into a balloon first allows the gas to warm before being administered.

High levels of pressure may rupture blood vessels in the lungs and force air into the chest cavity, causing the lungs to collapse. This is primarily a problem when nitrous is being administered directly from a tank or other pressurized container. Again, releasing the gas into a balloon first eliminates this risk.

Heavy and frequent nitrous use can deplete vitamin B12 in the body and lead to serious and unpleasant neurological problems. Users may experience numbness and tingling in the fingers, toes, lips, etc. In more severe cases, numbness of all extremeties. Taking B12 supplements, especially in combination with multi vitamin and complete amino acid supplements, may help alleviate this problem. If you experience these symptoms, cease nitrous use immediately and if the symptoms persist, seek medical attention.

Careless use of nitrous oxide can also cause nausea, vomiting, and disorientation, primarily from inhaling too much, too soon.

Since nitrous produces a temporary loss of motor control and dissociation, it's extremely unwise to inhale it while standing or while in any situation where unconsciousness is dangerous.

Some users of nitrous report headaches and generalized discomfort for an hour or more after inhalation.

Nitric Oxide, a toxic industrial gas, is occasionally mistaken for Nitrous Oxide. Users should be careful they know what they are inhaling. Inhaling Nitric Oxide can permanently damage the lungs or kill.


Olney's Lesions: there is little to no evidence that Nitrous Oxide use causes the brain lesions described in William White's "This is your Brain on Dissociatives" and, without further evidence, this hypothesis should be considered invalid for Nitrous Oxide.

[Alucard]

swim asked to bump this super old thread since it is currently relevant in their life now

is there a possibility while at least enhancing [potentiating] the opiate experience, this combination could also potentiate suppression of the CNS to the point of suffocation after passing out (after huffing the n2o) perhaps due to already decreased oxygen levels ???

just a thought

[fiveleggedrat]

Swim is currently experimenting with using DXM preloading in small doses (15-100mg) to potentiate opioids, currently hydromorphone. So far: Nothing really noticeable up to 30mg.

I do agree with bumping this thread. I have been hitting medical papers hard lately on opioid tolerance and reversing it when it is permanent, a problem Swim has.

Swim is seeing in many papers: NMDA antagonists have potential to interact with the Mu receptor in a positive way.

Swim has used nitrous in the same day as opioids, and no effect there. Perhaps immediate use after coming down from nitrous or taking nitrous while on opioids. Swim'll try this out in the future.

[Alucard]

swim tried 8.5g n2o while on 90mg oxycodone and experienced no physical effects of the nitrous, almost as if the opiates overpowered it (most likely)

it just left swim feeling somewhat confused... he will experiment more