Hello all. I am trying to find an answer for this, but nobody has been able to tell me on other forums. Anyway. I have been on Paxil and ......................................
DELETED due to your violating the rules against Self-Incrimination.
This is twice you have not bothered to read the rules here for these forums. No one here is going to tell you how to break the law and use y, z, or x. Read the rules and learn to avoid self-incrimination. If you post this same thing - unchanged - a third time, don't bother coming back.
In this study, venlafaxine and its O-desmethyl metabolite (ODV) were identified in postmortem tissue samples using liquid chromatography-atmospheric pressure ionisation-mass spectrometry (LC-APCI-MS) in positive ion mode following an n-butyl chloride extraction. In 12 postmortem cases, venlafaxine and ODV levels were as follows: 0.1-36 and <0.05-3.5 mg/l (peripheral blood), <0.05-22 and <0.05-9.9 mg/kg (liver, <0.05-10 and <0.05-1.5 mg/l (vitreous), <0.05-53 and <0.05-6.8 mg/l (bile), <0.05-55 and <0.05-21 mg/l (urine). Venlafaxine levels in the stomach contents ranged from 0.1-200 mg. Other drugs, besides venlafaxine, were present, including other antidepressants, alcohol, and benzodiazepines. The potential for interactions between venlafaxine and these other drugs is considered. None of the deaths studied could be attributed solely to venlafaxine.
Venlafaxine interacts with a long list of other medications. Anyone starting this drug should review the other medications they are taking with their physician and pharmacist for possible interactions. Patients should always inform all their health care providers, including dentists, that they are taking venlafaxine.
Dangerously high blood pressure, rapid changes in heart rate, high fever, muscle stiffness, and sudden muscle spasms have resulted from the combination of antidepressants, such as venlafaxine, and members of another class of antidepressants known as monoamine oxidase (MAO) inhibitors. Because of these serious adverse reactions, venlafaxine should never be taken in combination with MAO inhibitors. Patient taking any MAO inhibitors, for example Nardil (phenelzine sulfate) or Parmate (tranylcypromine sulfate), should stop the MAO inhibitor then wait at least 14 days before starting venlafaxine or a tricyclic antidepressant. The same holds true when discontinuing venlafaxine and starting an MAO inhibitor.
Some other drugs such as trazodone(Desyrel), sibutramine (Meridia), and sumatriptan (Imitrex) also interact with venlafaxine and cause a syndrome known as neuroleptic malignant syndrome, characterized by irritability, muscle stiffness, shivering, muscle spasms, and altered consciousness.
The sedative effects (drowsiness, lack of mental clarity) of venlafaxine are increased by other central nervous system depressants such as alcohol, sedatives, sleeping medications, or other medications used for mental disorders such as schizophrenia.
05-06-2006, 05:23
GHB + Effexor ??
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