Magnesium is an essential ion that your cells need for relaying signals... i.e. signals in neurons.
Mag depletion is quickly resolved with mag replacement, and this is probably what you've heard about amphetamine tolerance, dopamine, etc. However, mag is weird, in that you must replete other minerals as well, if you hope to hold onto the magnesium. Particularly, you have POTASSIUM! Also, calcium, phosphorus and b-complex are helpful in "kickstarting" the mag.
In short: take the Mag Sulfate, Drink Gatorade (doesn't have mag), and take a B-complex vitamin, &/or multi-vitamin. I wouldn't be surprised if you saw results in less than 24 hours...
If you're also consuming alcohol on a regular basis, this is a great source of magnesium depletion and other electrolyte disturbances that should be treated daily with the above recommendations.
Here's some information on mag: (from PDR/health)
Quote:
Magnesium is an essential mineral in human nutrition with a wide range of biological functions. Magnesium is involved in over 300 metabolic reactions. It is necessary for every major biological process, including the production of cellular energy and the synthesis of nucleic acids and proteins. It is also important for the electrical stability of cells, the maintenance of membrane integrity, muscle contraction, nerve conduction and the regulation of vascular tone, among other things.
Magnesium is an alkaline earth metal with atomic number 12 and an atomic weight of 24.31 daltons. Its chemical symbol is Mg. Magnesium exists under physiological conditions in its divalent (+2 or II) state. The total body magnesium content of an adult is about 25 grams. About 50%-60% exists in bone. Magnesium is the second most abundant intracellular cation; potassium is the most abundant. Approximately 1% of the body's magnesium is found extracellularly.
Magnesium is intimately interlocked, biologically with calcium. In some reactions, such as the synthesis of nucleic acids and protein, calcium and magnesium are antagonistic. Magnesium is necessary for these processes, while calcium can inhibit them. Magnesium and calcium cooperate, however, in the production of adenosine triphosphate or ATP. Magnesium has been called "nature's physiological calcium channel blocker" since it appears to regulate the intracellular flow of calcium ions.
Symptoms and signs of magnesium deficiency include anorexia, nausea and vomiting, diarrhea, generalized muscle spasticity, paresthesias, confusion, tremor, focal and generalized seizures, confusion, loss of coordination, cardiac arrhythmias, laboratory abnormalities, such as hypokalemia and hypocalcemia, muscle cramps, hypertension and coronary and cerebral vasospasms. Magnesium deficiency may be found in diabetes mellitus, malabsorption syndromes, alcoholism and hyperthyroidism, among other disorders. Use of certain drugs may also lead to magnesium deficiency. These drugs include thiazide diuretics (when used for long periods of time), loop diuretics, cisplatin, amphotericin, pentamidine (when used intravenously), aminoglycosides and cyclosporine. Magnesium deficiency itself is an important cause of hypokalemia.
In addition to its use for the treatment of hypomagnesemia, magnesium is used for the treatment of certain cardiac arrhythmias, in particular torsade de pointes, and eclampsia. It is also used as a laxative and antacid. Magnesium may also have value for the prevention of osteoporosis and for the management of migraine headaches in some. There is preliminary evidence that magnesium may help some with premenstrual syndrome, type 2 diabetes mellitus and hypertension. The role of magnesium, if any, in the management of acute myocardial infarction remains controversial.
Foods rich in magnesium include unpolished grains, nuts and green vegetables. Green leafy vegetables are particularly good sources of magnesium because of their chlorophyll content. Chlorophyll is the magnesium chelate of porphyrin. Meats, starches and milk are less rich sources of magnesium. Refined and processed foods are generally magnesium-poor. The mean daily magnesium intake in the U.S. in males nine years and older is estimated to be about 323 milligrams; for females nine years and older, it is estimated to be 228 milligrams. Some surveys report lower intakes, and some believe that the dietary intake for many may be sub-optimal.
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It may take a few days for the mag, K, multi-vitamins to work on restoring dopamine-levels... but I am almost certain that the answer to your question lies in replacing the magnesium that is depleted during the course of amphetamine &/or alcohol use. -Dick
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12-04-2006, 01:53
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