Combinations - Do benzos attenuate the effects of psychostimulants: study

[pharmapsyche]

Tonight SWIM is doing an experiment to determine whether a benzodiazepine-derivative (temazepam) attenuates the psychostimulant, rewarding, anoretic, and/or hypertensive effects of amphetamine and if so, to what degree? Subject will self-administer 90 milligrams of temazepam on an empty stomach. The subject has abused amphetamines many times before but is currently not tolerant to their effects. From 12:00 p.m. to 6.:00 p.m. subject administered a total of 210 milligrams of d,l-amphetamine salts. After I am finished and my observations are complete I'll post here...
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The current time is 11:12 a.m. Sunday. The experiment was carried out over the course of the entire evening and notes were taken periodically. A quick background of the experiment: subject took amphetamine/dextroamphetamine mixed salts on four different occasions yesterday starting at noon with the last dose taken at 6 p.m. The total dose was 250mgs. At 9:00 p.m. the subject took 90mgs of temazepam hydrochloride. Here are the words from my journal:

(T-0.00 HRS) I swallowed the 90mgs of temazepam on a completely empty stomach. It's been 3 hours since last amphetamine administration. I feel a few coming-down qualities here and there but nonetheless euphoria remains. I can't imagine how it feels to be sleepy or relaxed.

(T-0.30 HRS) A great change took place in my body after thirty minutes. Heartbeat still a little fast but not pounding anymore. Major, major change noted in muscles; very loose. Marked sedation is noted and continues to increase in intensity.

(T-1.00 HRS) A supplement of 30 milligrams temazepam was administered an hour into the experiment, bringing the total dosage to 120 milligrams. Heavily sedated and stoned. Very amnesiatic.

(T-? HRS) Time is 4:50 a.m. So sedated. Must lye down.

Conclusion: Temazepam, a benzodiazepine-derivative, attenuates the psychostimulant, rewarding, and hypertensive effects of amphetamine. This conclusion shows us how GABA neurotransmitters can extinguish psychostimulant effects.

Reputation Comments on this post:

quite informative, i had no idea this could happen

[Forthesevenlakes]

SWIM enjoyed reading this experiment, there should be a scientific journal for things like this. SWIM personally had no idea that a benzodiazepine could completely extinguish stimulant effects, and is impressed that SWIY could tolerate 210 mg of amphetamines.

[dr ACE]

according to SWIMalprazolam(xanax) can be used in the same way to reduce the effects of magic mushrooms