PCP receptors

[ssjoe6]

Does anyone know what receptors pcp works on and why the drug might produce dystonia or muscle rigidity?

how is rhabdomyolosis produced? What about the myoglobinuria? thanks.

[JewishNazi]

dissociatives work on the NDMA (or was it NMDA?) receptors. Just like
with seratonin and whatnot, there are sub types. Depending on which
subtype within this class it effects, and to what degree, it produces
different effects

[bounz2dabeatz]

its definetly the NMDA (N-methyl-D-Aspartate) receptors. The disoociatives(Ketamine, PCP, DXM,Nitrous) are all antagaonists of this receptor class. As for causing the muscle rigidity i havn't heard anything about that

[Benzeneringz]

Disassociatives also act on sigma-opioid receptors, although this might not explain dystonia.

[Forthesevenlakes]

whatever happened to the endopsychosin receptor and the search for something endogenous that would bind it? SWIM remembers when it was claimed that there was a separate subset of PCP receptors that dissociatives could also bind to. did they turn out to be a subset of sigma or NMDA receptors?