File Archive - Addiction Documents - Emotion, decision-making and substance dependence: a somatic-marker model of addiction (2006)

News Groups Blog Forum Chat Video Audio Images Documents Wiki Home

		Drugs Forum > File Archive > Documents > VARIOUS DRUG RELATED TOPICS > Addiction Documents
Emotion, decision-making and substance dependence: a somatic-marker model of addiction (2006)

Tags

FAQ n Rules

Mark Forums Read

Notices

Create a FREE account now to get access to more forums, more videos, more music, more documents, more images, more reviews, more news about drugs and much more functionality.
Start posting now, join our groups or create your unique profile.

links

Addiction Documents

Documents about addiction

New entries announced in forum Recovery and addiction

Allowances: 4.88 Mbytes/3.66 Mbytes used

[RSS Feed]

Entries

Emotion, decision-making and substance dependence: a somatic-marker model of addiction (2006)

Left click: open entry/Right click: save entry

Current Neuropharmacology 2006 Jan;4(1):17-31

Verdejo-García A, Pérez-García M, Bechara A.

Similar to patients with orbitofrontal cortex lesions, substance dependent individuals (SDI) show signs of impairments in decision-making, characterised by a tendency to choose the immediate reward at the expense of severe negative future consequences. The somatic-marker hypothesis proposes that decision-making depends in many important ways on neural substrates that regulate homeostasis, emotion and feeling. According to this model, there should be a link between abnormalities in experiencing emotions in SDI, and their severe impairments in decision-making in real-life. Growing evidence from neuroscientific studies suggests that core aspects of substance addiction may be explained in terms of abnormal emotional guidance of decision-making. Behavioural studies have revealed emotional processing and decision-making deficits in SDI. Combined neuropsychological and physiological assessment has demonstrated that the poorer decision-making of SDI is associated with altered reactions to reward and punishing events. Imaging studies have shown that impaired decision-making in addiction is associated with abnormal functioning of a distributed neural network critical for the processing of emotional information, including the ventromedial cortex, the amygdala, the striatum, the anterior cingulate cortex, and the insular/somato-sensory cortices, as well as non-specific neurotransmitter systems that modulate activities of neural processes involved in decision-making. The aim of this paper is to review this growing evidence, and to examine the extent of which these studies support a somatic-marker model of addiction.

Discussion Thread

Category Addiction Documents

Submitted by Jatelka

08-11-2008
173.30 Kbytes Hits 17

Category

Forum Jump

Sitelinks:	Site Functions:
Homepage Wiki Documents Image Gallery Audio Video Forum Blog Groups News	Site Rules Frequently Asked Questions Register to Participate Did you forget your password? All Threads

All times are GMT +1. The time now is 16:56.