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  MDMA use and neurocognition: a meta-analytic review (2007) Left click: open entry/Right click: save entry
Psychopharmacology 2007 Jan;189(4):531-7

Kalechstein AD, De La Garza R 2nd, Mahoney JJ 3rd, Fantegrossi WE, Newton TF.

RATIONALE: To determine the association between MDMA misuse and neurocognition using meta-analysis. OBJECTIVE: Separate analyses were conducted based on two sets of inclusion/exclusion criteria. A relatively stringent set required that the subjects be matched on important moderator variables, whereas the other did not. The study participants' performance in the following neurocognitive domains was reviewed: attention/concentration, verbal and nonverbal learning and memory, psychomotor speed and executive systems functioning. RESULTS: In the 11 studies meeting the relatively stringent inclusion/exclusion criteria for this review, MDMA use was associated with neurocognitive deficits in each domain. Similarly, in the 23 studies meeting the relatively lenient inclusion/exclusion criteria for this review, MDMA use was associated with neurocognitive deficits in each domain. Small to medium effect sizes were generally observed. A comparison of the effect sizes across the two sets of analyses did not reveal significant differences. CONCLUSIONS: The findings from this review reveal that MDMA use is associated with neurocognitive deficits. The implications of these findings are discussed

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12-04-2008
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Keywords: mdma neurotoxicity
 

 
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