File Archive - Opiate Addiction Documents - Brain levels of dextromethorphan and the intensity of opioid withdrawal in mice (2008)

News Groups Blog Forum Chat Video Audio Images Documents Wiki Home

		Drugs Forum > File Archive > Documents > VARIOUS DRUG RELATED TOPICS > Addiction Documents > Opiate Addiction Documents
Brain levels of dextromethorphan and the intensity of opioid withdrawal in mice (2008)

Tags

FAQ n Rules

Mark Forums Read

Notices

Create a FREE account now to get access to more forums, more videos, more music, more documents, more images, more reviews, more news about drugs and much more functionality.
Start posting now, join our groups or create your unique profile.

links

Opiate Addiction Documents

Documents about Opiate Addiction, Dependence and Withdrawal

New entries announced in forum Opiate addiction

Allowances: 4.88 Mbytes/798.56 Kbytes used

[RSS Feed]

Entries

Brain levels of dextromethorphan and the intensity of opioid withdrawal in mice (2008)

Left click: open entry/Right click: save entry

Bisaga A, Kos T, Wójcikowski J, Daniel WA, Popik P. Drug & Alcohol Dependence 2008 May 1;95(1-2):147-51. Epub 2008 Mar 6.

Consistent with their antagonistic actions at N-methyl-d-aspartate type glutamate receptors, dextromethorphan (DXM) and its metabolite, dextrorphan (DXT) decrease the intensity of opioid withdrawal syndrome. Since quinidine (QND) affects CYP2D6-mediated metabolism and P-glycoprotein governed transport, we sought to determine whether co-treatment with QND would affect brain levels of DXM and DXT as well as the effect of these compounds on opioid withdrawal syndrome in mice. We found that DXM dose dependently inhibited the intensity of opioid withdrawal syndrome and that there was a tendency for a further decrease when QND was co-administered with DXM. Administration of 30mg/kg of DXM resulted in higher brain levels of DXM and DXT than administration of 10mg/kg of DXM, but much lower DXT levels than that produced by 30mg/kg of DXT. Co-treatment with QND resulted in higher brain levels of DXM (but not DXT) suggesting that QND produces an increase in the brain availability of DXM. In summary, brain levels of DXM were inversely correlated with the intensity of opioid withdrawal syndrome. QND induced increased brain levels of DXM tend to attenuate the intensity of opioid withdrawal syndrome. We suggest that it is DXM, rather than DXT, that is responsible for the attenuating effect on the intensity of opioid withdrawal syndrome, and that the beneficial action of QND on the effect of DXM should be more pronounced in humans.

Discussion Thread

Category Opiate Addiction Documents DXM Documents

Submitted by Metomni

01-04-2008
460.37 Kbytes Hits 33

Category

Forum Jump

Sitelinks:	Site Functions:
Homepage Wiki Documents Image Gallery Audio Video Forum Blog Groups News	Site Rules Frequently Asked Questions Register to Participate Did you forget your password? All Threads

All times are GMT +1. The time now is 03:38.