File Archive - Benzodiazepines Documents - A statistical approach for classifying change in cognitive function in individuals following pharmacologic challenge: an example with alprazolam (2006)

News Groups Blog Forum Chat Video Audio Images Documents Wiki Home

		Drugs Forum > File Archive > Documents > CHEMICAL & (SEMI-) SYNTHETIC DRUGS > Downers Documents > Benzodiazepines Documents
A statistical approach for classifying change in cognitive function in individuals following pharmacologic challenge: an example with alprazolam (2006)

Tags

FAQ n Rules

Mark Forums Read

Notices

Create a FREE account now to get access to more forums, more videos, more music, more documents, more images, more reviews, more news about drugs and much more functionality.
Start posting now, join our groups or create your unique profile.

links

Benzodiazepines Documents

New entries announced in forum Downers and sleeping pills

Allowances: 4.88 Mbytes/208.61 Kbytes used

[RSS Feed]

Entries

A statistical approach for classifying change in cognitive function in individuals following pharmacologic challenge: an example with alprazolam (2006)

Left click: open entry/Right click: save entry

Psychopharmacology (2006) 186: 7–17

Paul Maruff . John Werth . Bruno Giordani .

Angela F. Caveney . Douglas Feltner . Peter J. Snyder

Abstract

Introduction: The effects of any drug treatment

on cognitive function are typically studied in groups of subjects. Observations made about the behavior of the drug, in the study sample, are then generalized to the population from which the sample was drawn. However, the magnitude and pharmacodynamic qualities of the response

to many central nervous system-active drugs are known to vary in the population. Therefore, it is useful to consider statistical models for the detection of cognitive change in response to a drug treatment in individual subjects.

Materials and methods: In this report, we first outline
the statistical assumptions and requirements for the reliable estimation of clinically relevant individual change in cognition. We then used the sedative benzodiazepine, alprazolam, as a pharmacologic challenge in healthy volunteer subjects to test our statistical model, using a parallel groups placebo-controlled study design. After treatment, the nature and severity of alprazolam-induced cognitive change was determined for each individual.
Results: Our proposed method and analysis showed an excellent sensitivity and specificity for alprazolam-related cognitive deterioration in individuals.
Discussion and conclusions: These findings, although preliminary, suggest that statistically reliable decisions about the effects of sedative drugs on cognition can be made for individuals.

Discussion Thread

Category Benzodiazepines Documents

Submitted by Jatelka

02-03-2008
160.87 Kbytes Hits 20
Keywords: cognition alprazolam memory

Category

Forum Jump

Sitelinks:	Site Functions:
Homepage Wiki Documents Image Gallery Audio Video Forum Blog Groups News	Site Rules Frequently Asked Questions Register to Participate Did you forget your password? All Threads

All times are GMT +1. The time now is 21:39.