File Archive - Opium, Opiate & Opioids Documents - Clinical pharmacology of opioids for pain (2002)

News Groups Blog Forum Chat Video Audio Images Documents Wiki Home

		Drugs Forum > File Archive > Documents > VARIOUS DRUGS > Opium, Opiate & Opioids Documents
Clinical pharmacology of opioids for pain (2002)

Tags

FAQ n Rules

Mark Forums Read

Notices

Create a FREE account now to get access to more forums, more videos, more music, more documents, more images, more reviews, more news about drugs and much more functionality.
Start posting now, join our groups or create your unique profile.

links

Opium, Opiate & Opioids Documents

Documents about Morphine, Codeine, Buprenorphine, Fentanyl, Heroin, Hydrocodone, Methadone, Oxycodone, Tramadol and other opiates and opioids.

New entries announced in forum Opium, Opiates & Opioids

Allowances: 4.88 Mbytes/0 bytes used

[RSS Feed]

Entries

Clinical pharmacology of opioids for pain (2002)

Left click: open entry/Right click: save entry

Clin J Pain. 2002 Jul-Aug;18(4 Suppl):S3-13

Inturrisi CE

The pharmacological effects of the opioid analgesics are derived from their complex interactions with three opioid receptor types (mu, delta, and kappa; morphine is an agonist at the mu opioid receptor). These receptors are found in the periphery, at presynaptic and postsynaptic sites in the spinal cord dorsal horn, and in the brain stem, thalamus, and cortex, in what constitutes the ascending pain transmission system, as well as structures that comprise a descending inhibitory system that modulates pain at the level of the spinal cord. The cellular effects of opioids include a decrease in presynaptic transmitter release, hyperpolarization of postsynaptic elements, and disinhibition. The endogenous opioid peptides are part of an endogenous pain modulatory system. A number of opioids are available for clinical use, including morphine, hydromorphone, levorphanol, oxymorphone, methadone, meperidine, oxycodone, and fentanyl, and their advantages and disadvantages for the management of pain are discussed. An understanding of the pharmacokinetic properties, as well as issues related to opioid rotation, tolerance, dependence, and addiction are essential aspects of the clinical pharmacology of opioids for pain

Discussion Thread

Category Opium, Opiate & Opioids Documents

Submitted by Jatelka

01-03-2008
62.58 Kbytes Hits 84
Keywords: pharmacology opioid

Category

Forum Jump

Sitelinks:	Site Functions:
Homepage Wiki Documents Image Gallery Audio Video Forum Blog Groups News	Site Rules Frequently Asked Questions Register to Participate Did you forget your password? All Threads

All times are GMT +1. The time now is 18:34.