File Archive - Opium, Opiate & Opioids Documents - Pharmacokinetic drug interactions of morphine, codeine, and their derivatives: theory and clinical reality, Part II (2003)

News Groups Blog Forum Chat Video Audio Images Documents Wiki Home

		Drugs Forum > File Archive > Documents > VARIOUS DRUGS > Opium, Opiate & Opioids Documents
Pharmacokinetic drug interactions of morphine, codeine, and their derivatives: theory and clinical reality, Part II (2003)

Tags

FAQ n Rules

Mark Forums Read

Notices

Create a FREE account now to get access to more forums, more videos, more music, more documents, more images, more reviews, more news about drugs and much more functionality.
Start posting now, join our groups or create your unique profile.

links

Opium, Opiate & Opioids Documents

Documents about Morphine, Codeine, Buprenorphine, Fentanyl, Heroin, Hydrocodone, Methadone, Oxycodone, Tramadol and other opiates and opioids.

New entries announced in forum Opium, Opiates & Opioids

Allowances: 4.88 Mbytes/1.11 Mbytes used

[RSS Feed]

Entries

Pharmacokinetic drug interactions of morphine, codeine, and their derivatives: theory and clinical reality, Part II (2003)

Left click: open entry/Right click: save entry

Psychosomatics. 2003 Nov-Dec;44(6):515-20.

Armstrong SC, Cozza KL

Pharmacokinetic drug-drug interactions with codeine, dihydrocodeine, hydrocodone, oxycodone, and buprenorphine are reviewed in this column. These compounds have a very similar chemical structure to morphine. Unlike morphine, which is metabolized chiefly through conjugation reactions with uridine diphosphate glucuronosyl transferase (UGT) enzymes, these five drugs are metabolized both through oxidative reactions by the cytochrome P450 (CYP450) enzyme and conjugation by UGT enzymes. There is controversy as to whether codeine, dihydrocodeine, and hydrocodone are actually prodrugs requiring activation by the CYP450 2D6 enzyme or UGT enzymes. Oxycodone and buprenorphine, however, are clearly not prodrugs and are metabolized by the CYP450 2D6 and 3A4 enzymes, respectively. Knowledge of this metabolism assists in the understanding for the potential of drug-drug interactions with these drugs. This understanding is important so that clinicians can choose the proper dosages for analgesia and anticipate potential drug-drug interactions

Discussion Thread

Category Opium, Opiate & Opioids Documents

Submitted by Jatelka

01-03-2008
65.75 Kbytes Hits 52
Keywords: codeine morphine pharmacokinetics

Category

Forum Jump

Sitelinks:	Site Functions:
Homepage Wiki Documents Image Gallery Audio Video Forum Blog Groups News	Site Rules Frequently Asked Questions Register to Participate Did you forget your password? All Threads

All times are GMT +1. The time now is 07:28.