File Archive - Opium, Opiate & Opioids Documents - Pharmacokinetic drug interactions of morphine, codeine, and their derivatives: theory and clinical reality, part I (2003)

News Groups Blog Forum Chat Video Audio Images Documents Wiki Home

		Drugs Forum > File Archive > Documents > VARIOUS DRUGS > Opium, Opiate & Opioids Documents
Pharmacokinetic drug interactions of morphine, codeine, and their derivatives: theory and clinical reality, part I (2003)

Tags

FAQ n Rules

Mark Forums Read

Notices

Create a FREE account now to get access to more forums, more videos, more music, more documents, more images, more reviews, more news about drugs and much more functionality.
Start posting now, join our groups or create your unique profile.

links

Opium, Opiate & Opioids Documents

Documents about Morphine, Codeine, Buprenorphine, Fentanyl, Heroin, Hydrocodone, Methadone, Oxycodone, Tramadol and other opiates and opioids.

New entries announced in forum Opium, Opiates & Opioids

Allowances: 4.88 Mbytes/3.31 Mbytes used

[RSS Feed]

Entries

Pharmacokinetic drug interactions of morphine, codeine, and their derivatives: theory and clinical reality, part I (2003)

Left click: open entry/Right click: save entry

Psychosomatics. 2003 Mar-Apr;44(2):167-71

Armstrong SC, Cozza KL

Pharmacokinetic drug-drug interactions with morphine, hydromorphone, and oxymorphone are reviewed in this column. Morphine is a naturally occurring opiate that is metabolized chiefly through glucuronidation by uridine diphosphate glucuronosyl transferase (UGT) enzymes in the liver. These enzymes produce an active analgesic metabolite and a potentially toxic metabolite. In vivo drug-drug interaction studies with morphine are few, but they do suggest that inhibition or induction of UGT enzymes could alter morphine and its metabolite levels. These interactions could change analgesic efficacy. Hydromorphone and oxymorphone, close synthetic derivatives of morphine, are also metabolized primarily by UGT enzymes. Hydromorphone may have a toxic metabolite similar to morphine. In vivo drug-drug interaction studies with hydromorphone and oxymorphone have not been done, so it is difficult to make conclusions with these drugs

Discussion Thread

Category Opium, Opiate & Opioids Documents

Submitted by Jatelka

01-03-2008
55.66 Kbytes Hits 38
Keywords: codeine interactions morphine pharmacokinetics

Category

Forum Jump

Sitelinks:	Site Functions:
Homepage Wiki Documents Image Gallery Audio Video Forum Blog Groups News	Site Rules Frequently Asked Questions Register to Participate Did you forget your password? All Threads

All times are GMT +1. The time now is 23:23.