File Archive - Piperazines Documents - MDMA-like behavioral effects of N-substituted piperazines in the mouse (2007)

News Groups Blog Forum Chat Video Audio Images Documents Wiki Home

		Drugs Forum > File Archive > Documents > CHEMICAL & (SEMI-) SYNTHETIC DRUGS > Research Chemicals Documents > Piperazines Documents
MDMA-like behavioral effects of N-substituted piperazines in the mouse (2007)

Tags

FAQ n Rules

Mark Forums Read

Notices

Create a FREE account now to get access to more forums, more videos, more music, more documents, more images, more reviews, more news about drugs and much more functionality.
Start posting now, join our groups or create your unique profile.

links

Piperazines Documents

Documents about BZP, TFMPP, mCPP, 5-MeO-BZP

New entries announced in forum Research Chemicals

Allowances: 4.88 Mbytes/3.34 Mbytes used

[RSS Feed]

Entries

MDMA-like behavioral effects of N-substituted piperazines in the mouse (2007)

Left click: open entry/Right click: save entry

Pharmacol Biochem Behav. 2007 Nov;88(1):18-27. Epub 2007 Jul 6

Yarosh HL, Katz EB, Coop A, Fantegrossi WE

Few studies have characterized the subjective effects of N-substituted piperazines, but these drugs show potential for abuse in humans, and have often been associated with MDMA ("ecstasy") in this regard. The aim of the present study was to test the capacity of N-substituted piperazines to induce a head twitch response, alter locomotor activity, and induce MDMA-like discriminative stimulus effects in mice. Various doses of l-benzylpiperazine (BZP), 1-(3-trifluoromethylphenyl) piperazine (TFMPP), 1-(3-methoxybenzyl) piperazine (m-MeO-BZP) or meta-chlorophenyl piperazine (m-CPP) were administered to mice to determine the effects on these behavioral endpoints. BZP, but not its meta-methoxyl analogue, increased locomotor activity in a dose-dependent manner; the phenylpiperazines and m-MeO-BZP only decreased locomotor activity. TFMPP was the only compound active in the head twitch assay, eliciting a moderate head twitch response which was comparable to that previously observed with the MDMA enantiomers. BZP, TFMPP and m-CPP fully substituted in S(+)-MDMA-trained animals, but did not elicit significant drug lever responding in mice trained to discriminate R(-)-MDMA. m-MeO-BZP partially substituted for both training drugs. The present results suggest that BZP has stimulant-like effects, and that TFMPP has hallucinogen-like effects. Their structural analogues, however, do not share these behavioral profiles. Further studies into the relationships between the N-substituted piperazines and MDMA are warranted.

Discussion Thread

Category Piperazines Documents

Submitted by Jatelka

24-02-2008
806.17 Kbytes Hits 14
Keywords: piperazines

Category

Forum Jump

Sitelinks:	Site Functions:
Homepage Wiki Documents Image Gallery Audio Video Forum Blog Groups News	Site Rules Frequently Asked Questions Register to Participate Did you forget your password? All Threads

All times are GMT +1. The time now is 05:15.