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Potential γ-Hydroxybutyric acid (GHB) Drug Interactions Through Blood–Brain Barrier Transport Inhibition: A Pharmacokinetic Simulation-Based Evaluation (2006)

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GHB & GBL Documents

Documents about GHB, GBL, BDO, gamma-Hydroxybutyrate, Sodium Oxybate, Xyrem, gamma-Butyrlactone, 1,4-Butanediol

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Potential γ-Hydroxybutyric acid (GHB) Drug Interactions Through Blood–Brain Barrier Transport Inhibition: A Pharmacokinetic Simulation-Based Evaluation (2006)

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Journal of Pharmacokinetics and Pharmacodynamics 2006 Oct;33(5):657-81.

Bhattacharya I, Boje KM

Recreational abuse or overdose of γ-hydroxybutyric acid (GHB) results in dose-dependent central nervous system (CNS) effects including death. As GHB undergoes monocarboxylic acid transporter (MCT)-mediated transport across the blood–brain barrier (BBB), one possible strategy for the management of GHB toxicity/overdose involves inhibition of GHB BBB transport. To test this strategy, interactions between GHB and MCT substrates (salicylic acid or probenecid) were simulated

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Category GHB & GBL Documents

Submitted by Bajeda

21-06-2007
191.01 Kbytes Hits 22
Keywords: interaction ghb drug

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