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Low dose melatonin improves sleep in healthy middle-aged subjects (1996)

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Low dose melatonin improves sleep in healthy middle-aged subjects (1996)

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Psychopharmacology (Berl). 1996 Jul;126(2):179-81

Attenburrow ME, Cowen PJ, Sharpley AL

We studied the effects of single evening doses of melatonin (0.3 mg and 1.0 mg orally) on polysomnographically measured sleep in 15 healthy middle-aged volunteers, using a placebo-controlled, double-blind, cross-over design. Compared to placebo, the 1.0 mg dose of melatonin significantly increased Actual Sleep Time, Sleep Efficiency, non-REM Sleep and REM Sleep Latency. These data are consistent with the hypothesis that low dose melatonin has hypnotic effects in humans. It is possible that administered melatonin may have a role to play in the treatment of sleep disorders.

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