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Pharmacology Documents

Documents about Pharmacology in general. Not for documents on specific substances. For broad ranged documents, first check out if it fits in the categories: 'Hallucinogens', 'downers', 'dissociatives' or 'stimulants'.

New entries announced in forum Pharmacology

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Entries

A case of erectile dysfuntion associated with chronic methyl bromide intoxication

Left click: open entry/Right click: save entry

Submitted by Heretic.Ape.

07-05-2007
51.84 Kbytes Hits 48
Keywords: intoxication

A homology-based model of the human 5-HT2A receptor derived from an in silico activated G-protein coupled receptor

Abstract: A homology-based model of the 5-HT2A receptor was produced utilizing an activated form of the bovine rhodopsin (Rh) crystal structure [1,2]. In silico activation of the Rh structure was accomplished by isomerization of the 11-cis-retinal (1) chromophore, followed by constrained molecular...

Submitted by Metomni

16-04-2008
323.21 Kbytes Hits 33

A Manual of Pharmacology and Its Applications to Therapeutics and Toxicology

Published 1917 by Saunders.

Downloadable PDF (41.3 MB) hosted on Google Books.

Interesting from a historical perspective (includes things such as cannabis, cocaine, opiates, hops, etc).

If the file doesn't open, try http://books.google.com/books?id=l1AQ9w_iFMoC&printsec=frontcover
You can...

See also Drug History Documents

Submitted by Paracelsus

28-01-2008
1.43 Kbytes Hits 170

A rating Scale for Drug Induced Akathisia

From the Brithish Journal of Psychiatry 1989 - Barnes Akathisia Scale. Akathisia is a state of "inner restlessness" and can be caused by a range of drugs, notably anti psychotics, SSRI and tricyclic antidepressants, antihistamines and anti-emetic drugs.

Submitted by ~lostgurl~

01-01-2007
344.46 Kbytes Hits 51
Keywords: ssri anti-psychotics antidepressant antihistamines

Abstinence symptoms after withdrawal from tranquillising drugs; is there a common neurochemical mechanism?

Cowen PJ & Nutt DJ. (1982). Abstinence symptoms after withdrawal from tranquillising drugs; is there a common neurochemical mechanism? Lancet, 2: 360-2.

Abstract: Withdrawal of anxiolytic agents such as ethanol, barbiturates, and benzodiazepines may result in a syndrome characterised in its most...

See also Downers Addiction Documents Downers Documents

Submitted by Bajeda

30-06-2009
479.98 Kbytes Hits 12
Keywords: withdrawal ethanol barbituates gaba benzodiazepines alcohol

Acetylcholine

Chapter from Neuropsychopharmacology: The Fifth Generation of Progress

Submitted by Jatelka

11-11-2007
223.04 Kbytes Hits 40
Keywords: acetylcholine pharmacology

Activation of adenosine1 (A1) receptors suppresses head shakes induced by a serotonergic hallucinogen in rats

Gerard J. Marek

Modulation of glutamatergic neurotransmission by metabotropic glutamate2/3 (mGlu2/3) receptor agonists effectively treats seemingly diverse neuropsychiatric illness such as generalized anxiety disorder and schizophrenia. Activation of adenosine A1 heteroceptors, like mGlu2...

Submitted by Gradient

07-08-2009
157.44 Kbytes Hits 1

An endocannabinoid hypothesis of drug reward

The dopamine hypothesis of drug reward remains a difficult area of research and perhaps a major problem and hindrance to progress in unraveling the biology of addiction. Pharmacological treat-ment of drug dependency has been disappointing and new therapeutic targets and hypotheses are needed. Since...

Submitted by Shampoo

03-01-2009
188.46 Kbytes Hits 16
Keywords: reward addiction

Antioxidant compounds protect dopamine neurons from death due to oxidative stress in vitro

Natalie D. Stull, David P. Polan and Lorraine Iacovitti

Using tissue culture models of oxidative stress caused by serum deprivation or MPTP/MPP+ toxicity, the present study establishes that the antioxidants epigallocatechin gallate, lazaroids U74389G and U83836E, reservatrol, MnTBAP, MCI 186,...

Submitted by Gradient

11-08-2009
1.52 Mbytes Hits 3

AntiRetrovirals and Drugs of Abuse (Wynn et al, 2005)

Originally published in Psychosomatics

Looks at the interactions of HIV drugs with various drugs, including alcohol, benzodiazepines, cocaine, GHB, ketamine, LSD, MDMA, opiates, PCP and marijuana

Discussion Thread

Submitted by Jatelka

05-07-2007
76.59 Kbytes Hits 55
Keywords: benzodiazepines ghb interactions marijuana cocaine hiv lsd mdma

Assessing abuse liability during drug development: changing standards and expectations (2008)

Clinical Pharmacology and Therapeutics 2008 Apr;83(4):622-6

Schoedel KA, Sellers EM

As public health concerns have changed, regulatory expectations for assessing abuse liability of new central nervous system (CNS) drugs have increased. All CNS-active drugs with any properties indicating...

Submitted by Jatelka

12-04-2008
120.86 Kbytes Hits 29
Keywords: abuse

Barbiturate tolerance: effects on GABA-operated chloride channel function

Allan AM, Zhang X, & Baier LD. (1992). Barbiturate tolerance: effects on GABA-operated chloride channel function. Brain Research, 588(2):255-60.

Abstract: Male ICR mice were fed powdered laboratory chow containing phenobarbital for 7 days to induce tolerance. Mice were sacrificed and brains...

See also Downers Documents

Submitted by Bajeda

30-06-2009
753.40 Kbytes Hits 7
Keywords: tolerance ethanol benzodiazepines phenobarbital cross-tolerance alcohol

Beta-Carboline alkaloids: biochemical and pharmacological functions.

Curr Med Chem 2007;14(4):479-500

Abstract: 􀀂-Carboline alkaloids are a large group of natural and synthetic indole alkaloids with different degrees of aromaticity,
some of which are widely distributed in nature, including various plants, foodstuffs, marine creatures, insects,
mammalians as...

Submitted by Quantum Dude

11-01-2009
494.10 Kbytes Hits 18

Bromism from daily over intake of bromide salt

Submitted by Heretic.Ape.

07-05-2007
56.90 Kbytes Hits 62

Buccal mucosa as a route for systemic drug delivery: a review (Shojaei)

From JPPS 1(1), 1998

Submitted by Heretic.Ape.

12-05-2007
331.25 Kbytes Hits 105
Keywords: buccal

Cannabinoid agonist WIN 55212-2 speeds up the cone response to light offset in goldfish retina

Goldfish cones contain CB1 receptors at the synaptic terminal, selectively accumulate 3H-anandamide, and contain fatty acid amide hydrolase-immunoreactivity, and voltage-gated calcium and potassium currents are modulated by CB1 ligands (Yazulla et al., 2000; Fan & Yazulla, 2003; Glaser et al.,...

Submitted by Shampoo

04-05-2009
440.81 Kbytes Hits 4
Keywords: cell goldfish retina rod cannabis cannabinoids

Cannabinoid-induced tolerance is associated with a CB1 receptor G protein coupling switch that is prevented by ultra-low dose rimonabant.

The analgesic effect of opioids is enhanced, and tolerance is attenuated, by ultra-low doses (nanomolar to picomolar) of an opioid antagonist, an effect that is mediated by preventing the receptor from coupling to Gs proteins. Recently, we demonstrated a cannabinoid-opioid interaction at the...

Submitted by nibble

05-08-2009
1.80 Mbytes Hits 3
Keywords: cb1 cannabinoid antagonist win55212-2 tolerance rimonabant

Cardiovascular toxicity of antihistamines

The efficacy of individual antihistamines is similar for most indications. The primary difference between traditional (first-generation) and nonsedating (second-generation) histamine1-receptor antagonists is the incidence and severity of adverse reactions. The first-generation drugs are associated...

Submitted by Gradient

08-07-2009
1.34 Mbytes Hits 3

Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs

Abstract: Substance abuse and addiction are the most costly of all the neuropsychiatric disorders. In the last decades, much progress has been achieved in understanding the effects of the drugs of abuse in the brain. However, efficient treatments that prevent relapse have not been developed. Drug...

See also Opium, Opiate & Opioids Documents Cocaine & Crack Documents Amphetamine Documents

Submitted by Gradient

19-07-2009
569.08 Kbytes Hits 22

Clinically relevant drug interactions with antiepileptic drugs

Some patients with difficult-to-treat epilepsy benefit from combination therapy with two or more antiepileptic drugs (AEDs). Additionally, virtually all epilepsy patients will receive, at some time in their lives, other medications for the management of associated conditions. In these situations,...

Submitted by staples

31-08-2009
121.22 Kbytes Hits 2
Keywords: levetiracetam antiepileptic pregabalin lyrica gabapentin

Clinically Significant Cytochrome P450 Drug Interactions - Goshman, Fish & Roller

Everything you ever wanted to know about P450, & how it affects bio-pharmacy...

Submitted by Micklemouse

04-07-2006
313.73 Kbytes Hits 120
Keywords: interaction p450 cytochrome

Combining stimulants with monoamine oxidase inhibitors (2004)

Feinberg SS. Journal of Clinical Psychiatry 2004 Nov;65(11):1520-4.

BACKGROUND: Among antidepressant augmentation strategies, the addition of a stimulant to a monoamine oxidase inhibitor (MAOI) has received little attention in the literature in recent years because of the diminished clinical use...

See also Stimulants in general Documents

Submitted by Metomni

02-04-2008
47.53 Kbytes Hits 67

Comparison of the discriminative stimulus effects of salvinorin A and its derivatives to U69,593 and U50,488 in rats

Baker LE, Panos JJ, Killinger BA, Peet MM, Bell LM, Haliw LA, Walker SL. (2009). Comparison of the discriminative stimulus effects of salvinorin A and its derivatives to U69,593 and U50,488 in rats. Psychopharmacology, 203(2): 203-211.

Abstract: This study compared the discriminative stimulus...

See also Salvia Documents

Submitted by Bajeda

30-06-2009
195.13 Kbytes Hits 6
Keywords: kappa-opioid-receptor salvinorin salvia-divinorum

Crystaline Serotonin (1948)

[This was in the days before abstracts...]

This paper details the isolation of serotonin (5-HT) from bovine serum.

Submitted by Synchronium

12-04-2009
507.32 Kbytes Hits 5

Cycloalkanecarboxylic Esters Derived from Lysergol, Dihydrolysergol-I, and Elymoclavine as Partial Agonists and Antagonists at Rat 5-HT2A Receptors: Pharmacological Evidence that the Indolo[4,3-fg]quinoline System of the Ergolines Is Responsible for High

Three series of cycloalkanecarboxylic esters derived from the naturally occurring clavine
alkaloids lysergol, dihydrolysergol-I, and elymoclavine were synthesized to study their
interaction with 5-HT2A receptors and R1-adrenoceptors in rat tail artery and aorta, respectively.
Especially...

Submitted by trptamene

10-11-2007
193.73 Kbytes Hits 31

Debunking the Effects of Taurine in Red Bull Energy Drink

Interesting deconstruction of Red Bulls claims about taurine's role in it's product's "cognitive & muscular enhancement".

Submitted by Micklemouse

28-12-2007
109.42 Kbytes Hits 107

Designer Drugs That Are Potent Inhibitors of CYP2D6 (D Pritzker et al 2002)

Journal of Clinical Psychopharmacology 2002 Jun;22(3):330-2.

Authors: David Pritzker, Anish Kanungo, Tansel Kilicarslan, Rachel F. Tyndale and Edward M. Sellers

See also Research Chemicals Documents

Submitted by ThirdEyeFloond

23-01-2008
172.53 Kbytes Hits 75
Keywords: cytochrome

Development of novel tail-modiﬁed anandamide analogs

To explore the hydrophobic groove subsite within the CB1 cannabinoid receptor we have designed and
synthesized a group of tail-substituted anandamide analogs. Our design involves the introduction of aryl
or heterocyclic ring as terminal substituents that are connected to the last...

Submitted by helikophis

17-05-2009
355.82 Kbytes Hits 4

Dietary oxyresveratrol prevents parkinsonian mimetic 6-hydroxydopamine neurotoxicity

Jianfei Chaoa, b, Man-Shan Yub, Yuen-Shan Hob, c, Mingfu Wanga, , and Raymond Chuen-Chung Chang

Oxyresveratrol (OXY) is a polyhydroxylated stilbene existing in mulberry. Increasing lines of evidence have shown its neuroprotective effects against Alzheimer disease and stroke. However, little is...

Submitted by Gradient

11-08-2009
1.14 Mbytes Hits 0

Differential Actions of an Entactogen Compared to a Stimulant and a Hallucinogen in Healthy Humans (Gouzoulis-Mayfrank, 2001)

Originally published in The Heffter Review of Psychedelic Research.

Submitted by Jatelka

05-02-2007
252.29 Kbytes Hits 54
Keywords: stimulant hallucinogens entactogen

Dopamine

Chapter from Neuropsychopharmacology: The Fifth Generation of Progress. An in depth look at the role of dopamine (not specifically related to drugs)

Submitted by Jatelka

01-08-2006
208.68 Kbytes Hits 91
Keywords: pharmacology dopamine

Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis

[Dopamine supersensitivity occurs in schizophrenia and other psychoses, and after hippocampal lesions, antipsychotics, ethanol, amphetamine, phencyclidine, gene knockouts involving dopamine receptors and enzymes that function in dopamine-containing neurons.

The functional state of D2, or the...

Submitted by Ilsa

26-02-2009
748.04 Kbytes Hits 18

Drug-Grapefruit Juice Interactions (Kane and Lipsy, 2000)

Originally published in The Mayo Clinic Proceedings.
Covers much of the same material as the other review article

Submitted by Jatelka

04-01-2007
54.19 Kbytes Hits 77
Keywords: p450 drug interaction grapefruit cytochrome

Drugs of Abuse Specifically Sensitize Noradrenergic and Serotonergic Neurons Via a Non-Dopaminergic Mechanism (2007)

Neuropsychopharmacology. 2007 Sep 5 (epublished)

Lanteri C, Salomon L, Torrens Y, Glowinski J, Tassin JP

A challenge in drug dependence is to delineate long-term neurochemical modifications induced by drugs of abuse. Repeated d-amphetamine was recently shown to disrupt a mutual regulatory...

Submitted by Jatelka

13-04-2008
223.49 Kbytes Hits 18

Drugs, pregnancy and lactation

Submitted by Alfa

08-12-2006
102.77 Kbytes Hits 79

Effect of omeprazole treatment on diazepam plasma levels in slow versus normal rapid metabolizers of omeprazole

Andersson T, Cederberg C, Edvardsson G, Heggelund A, & Lundborg P. (1990). Effect of omeprazole treatment on diazepam plasma levels in slow versus normal rapid metabolizers of omeprazole. Clinical Pharmacology & Therapeutics, 47(1):79-85.

Abstract: The effect of omeprazole treatment on diazepam...

See also Benzodiazepines Documents

Submitted by Bajeda

30-06-2009
515.45 Kbytes Hits 4
Keywords: diazepam metabolism omeprazole

Effects of excersise on the pharmacokinetics of drugs

JPPS 3 (3), 2000

Submitted by Heretic.Ape.

12-05-2007
116.73 Kbytes Hits 51

Effects of NMDA receptor antagonists and sigma ligands on the acquisition of conditioned fear in mice (1991)

Psychopharmacology 1991;104(1):27-34.

Sanger DJ, Joly D.

Recent studies have shown that several compounds known to act as competitive or non-competitive antagonists of NMDA receptors can disrupt learning in rodents. The present study was carried out to investigate the effects of a range of...

See also Dissociatives Documents

Submitted by Bajeda

06-07-2007
1015.55 Kbytes Hits 24
Keywords: receptors nmda memory learning

Effects of Pomegranate Juice on CY3PA and Carbamazepine Pharmacokinetics in Rats (Hidaka et al, 2004)

Originally published in Drug Metabolism and Disposition

Concludes that pomegranate is as effective an inhibitor as grapefruit juice.

Submitted by Jatelka

11-01-2008
128.82 Kbytes Hits 72
Keywords: fruit-juice cytochrome

Exposure-Dependent Inhibition of Intestinal and Hepatic CYP3A4 In Vivo by Grapefruit Juice.

Consumption of typical quantities of grapefruit juice (GFJ) increases the oral bioavailability of several CYP3A4 substrates without affecting their elimination, consistent with selective inhibition of intestinal but not hepatic CYP3A4. However, increases in the AUCs of CYP3A4 substrates recently...

Submitted by trptamene

09-10-2007
1.38 Mbytes Hits 89
Keywords: grapefruit metabolism benzodiazepines cytochrome

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