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Dissociatives Documents
Documents about DXM, Ketamine, Nitrous Oxide (N2O), PCP
New entries announced in forum CHEMICAL & (SEMI-) SYNTHETIC DRUGS
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Access denied Acute D2/D3 Dopaminergic Agonism but Chronic D2/D3 Antagonism Prevents NMDA Antagonist Neurotoxicity (2006)
BIOL PSYCHIATRY 2006;60:630–638

Nuri B. Farber, Brian Nemmers, Kevin K. Noguchi

BACKGROUND: Antagonists of the N-methyl-D-aspartate (NMDA) glutamate receptor, most likely by producing disinhibtion in complex circuits, acutely produce psychosis and cognitive disturbances in humans, and... 		 
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Submitted by ThirdEyeFloond Find all entries from this user
16-01-2008
578.08 Kbytes Hits 21
Keywords: nmda dopamine neurotoxicity
Access denied Age-Specific Neurotoxicity in the Rat Associated with NMDA Receptor Blockade: Potential Relevance to Schizophrenia? (1995)
BIOL PSYCHIATRY 1995;38:788-796

Nuri B. Farber, David F. Wozniak, Madelon T. Price, Joann Labruyere, Janice Huss, Heidi St. Peter, and John W. Olney

Agents that block the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor induce a schizophrenialike psychosis in adult humans and... 		 
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Submitted by ThirdEyeFloond Find all entries from this user
16-01-2008
900.34 Kbytes Hits 16
Keywords: neurotoxicity nmda
Access denied Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism (2004)
American Journal of Psychiatry 2004 Oct;161(10):1776-82.

Petrakis IL, Limoncelli D, Gueorguieva R, Jatlow P, Boutros NN, Trevisan L, Gelernter J, Krystal JH.

OBJECTIVE: A family history of alcoholism is a risk factor for the development of ethanol dependence. Ethanol is an antagonist of...

See also Alcohol Documents  		 
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Submitted by Paracelsus Find all entries from this user
13-11-2007
159.51 Kbytes Hits 76
Keywords: alcoholism addiction ketamine
Access denied Antiepileptic drugs and agents that inhibit voltage-gated sodium channels prevent NMDA antagonist neurotoxicity (2002)
Molecular Psychiatry [2002] 7, 72&-733

NB Farber, X-P Jiang, C Heinkel and B Nemmers

N-methyl-D-aspartate (NMDA) glutamate receptor antagonists are used in clinical anesthesia and are being developed as therapeutic agents for preventing neurodegeneration in stroke, epilepsy, and brain... 		 
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Submitted by ThirdEyeFloond Find all entries from this user
16-01-2008
3.78 Mbytes Hits 11
Keywords: neurotoxicity nmda
Access denied Antioxidants attenuate MK-801-induced cortical neurotoxicity in the rat (CL. Willis et al. 2006)
NeuroToxicology 28 (2007) 161–167

Colin L. Willis, David E. Ray

Oxidative stress has been implicated in the pathogenesis of several neurodegenerative diseases and may result from excessive free radical production due to increased local metabolism. Non-competitive N-methyl-D-aspartate (NMDA)... 		 
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Submitted by ThirdEyeFloond Find all entries from this user
16-01-2008
485.46 Kbytes Hits 19
Keywords: mk-801 neurotoxicity
Access denied Assessment of the effect of dextromethorphan and ketamine on the acute nociceptive threshold and wind-up of the second pain response in healthy male volunteers.
Hughes AM, Rhodes J, Fisher G, Sellers M, Growcott JW. British Journal of Clinical Pharmacology 2002 Jun;53(6):604-612.

AIMS: The aim of this study was to assess the efficacy of dextromethorphan and ketamine relative to placebo on the acute nociceptive threshold and wind-up of second pain... 		 
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Submitted by Paracelsus Find all entries from this user
21-10-2007
97.60 Kbytes Hits 53
Keywords: dxm
Access denied Effect of Age and Sex on N-Methyl-D-Aspartate Antagonist-Induced Neuronal Necrosis in Rats (1996)
Stroke. 1996;27:743-746.

Roland N. Auer, MD, PhD

BACKGROUND AND PURPOSE: Although N-methyl-D-aspartate (NMDA) antagonism may be a useful therapeutic approach in stroke treatment, it has been found that these pharmacological agents cause neuronal necrosis in restricted cortical regions of... 		 
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Submitted by ThirdEyeFloond Find all entries from this user
16-01-2008
249.08 Kbytes Hits 35
Keywords: nmda neurotoxicity
Access denied Effects of NMDA receptor antagonists and sigma ligands on the acquisition of conditioned fear in mice (1991)
Psychopharmacology 1991;104(1):27-34.

Sanger DJ, Joly D.

Recent studies have shown that several compounds known to act as competitive or non-competitive antagonists of NMDA receptors can disrupt learning in rodents. The present study was carried out to investigate the effects of a range of...

See also Pharmacology Documents  		 
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Submitted by Bajeda Find all entries from this user
06-07-2007
1015.55 Kbytes Hits 28
Keywords: receptors nmda memory learning
Access denied In the adult CNS, ethanol prevents rather than produces NMDA antagonist-induced neurotoxicity.
Farber NB, Heinkel C, Dribben WH, Nemmers B, Jiang X.

Brain Res. 2004 Nov 26;1028(1):66-74.

Abstract:
Single doses of an NMDA antagonist cause an adult or a prepubertal form of neurodegeneration, depending on the age of the animal. Single doses of ethanol (EtOH) by blocking NMDA receptors... 		 
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Submitted by Salvinorin A Find all entries from this user
15-01-2010
408.70 Kbytes Hits 12
Access denied Muscimol prevents NMDA antagonist neurotoxicity by activating GABAA receptors in several brain regions (2003)
Brain Research 993 (2003) 90–100

Nuri B. Farber, Xiaoping Jiang, Krikor Dikranian, Brian Nemmers

N-Methyl-D-aspartate (NMDA) glutamate receptor antagonists are being developed as therapeutic agents for several clinical conditions. However, the ability of these agents to produce... 		 
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Submitted by ThirdEyeFloond Find all entries from this user
16-01-2008
462.73 Kbytes Hits 24
Keywords: nmda neurotoxicity
Access denied Neuroprotective and neurotoxic properties of the 'inert' gas, xenon
Ma D, Wilhelm S, Maze M, Franks NP. British Journal of Anaesthesia 2002;89(5):739-46.

BACKGROUND: Antagonists of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors have been shown not only to have neuroprotective effects but also to exhibit neurotoxic properties. In this study, we... 		 
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Submitted by Paracelsus Find all entries from this user
13-11-2007
329.23 Kbytes Hits 91
Access denied Neuropsychotoxicity of abused drugs: potential of dextromethorphan and novel neuroprotective analogs of dextromethorphan with improved safety profiles in terms of abuse and neuroprotective effects
Shin EJ, Lee PH, Kim HJ, Nabeshima T, Kim HC. Journal of Pharmacological Sciences 2008 Jan;106(1):22-7.

Drug abuse involving dextromethorphan, an antitussive, has been a social problem in various geographic locations since the 1960s. Ironically, high doses of the drug confer neuroprotective...

See also DXM Documents  		 
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Submitted by ThirdEyeFloond Find all entries from this user
21-01-2008
455.74 Kbytes Hits 51
Keywords: dxm
Access denied NMDA Receptor Antagonists Disinhibit Rat Posterior Cingulate and Retrosplenial Cortices: A Potential Mechanism of Neurotoxicity (2002)
The Journal of Neuroscience, April 15, 2002, 22(8):3070–3080

Qiang Li, Suzanne Clark, Darrell V. Lewis, and Wilkie A. Wilson

NMDA receptor antagonists produce region-specific neurodegeneration by an undetermined mechanism, but one proposed mechanism involves disinhibition. In certain areas... 		 
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Submitted by ThirdEyeFloond Find all entries from this user
16-01-2008
601.91 Kbytes Hits 14
Keywords: nmda neurotoxicity
Access denied Ontogeny of the N-Methyl-D-Aspartate (NMDA) Receptor System and Susceptibility to Neurotoxicity (2002)
TOXICOLOGICAL SCIENCES 68, 9–17 (2002)

Kathleen A. Haberny, Merle G. Paule, Andrew C. Scallet, Frank D. Sistare, David S. Lester, Joseph P. Hanig and William Slikker, Jr.

The NMDA receptor has been widely investigated in recent years as a target for the pharmacological management of... 		 
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Submitted by ThirdEyeFloond Find all entries from this user
16-01-2008
119.04 Kbytes Hits 85
Keywords: nmda neurotoxicity
Access denied Paradoxical effects of very low dose MK-801 (2006)
European Journal of Pharmacology 537 (2006) 77–84

Yuanjia Tang, Hong Zou, Judith A. Strong, Yiwen Cui, Qinglian Xie, Guoping Zhao, Meilei Jin, Lei Yu

Systemic injection of the noncompetitive NMDA (N-methyl-D-aspartate) receptor antagonist MK-801 (dizocilpine maleate) is known to cause... 		 
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Submitted by ThirdEyeFloond Find all entries from this user
23-01-2008
233.94 Kbytes Hits 36
Keywords: mk-801
Access denied Percutaneous Absorption of Some Narcotic Drugs in Dimethyl Sulfoxide
Wellon D. Collom and Charles L. Winek
Clinical Toxicology: 1968, Vol. 1, No. 3, Pages 309-317 , DOI 10.3109/15563656808990584 		 
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Submitted by nnizzle Find all entries from this user
13-05-2010
602.21 Kbytes Hits 2
Access denied Pharmacology of Glutamate Neurotoxicity in Cortical Cell Culture: Attenuation by NMDA Antagonists (1988)
The Journal of Neuroscience, January 1988, 8(1): 165-196

Dennis W. Choi, Jae-young Koh, and Stephen Peters

The antagonist pharmacology of glutamate neurotoxicity was quantitatively examined in murine cortical cell cultures. Addition of 1-3 mM DL-2-amino-5-phosphonovalerate (APV), or its... 		 
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Submitted by ThirdEyeFloond Find all entries from this user
16-01-2008
2.40 Mbytes Hits 5
Keywords: pharmacology nmda neurotoxicity
Access denied Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate / retrosplenial cortex (2001)
Brain Research 913 (2001) 185–189

Vesna Jevtovic-Todorovica, David F. Wozniakb, Sarah Powell and John W. Olney

N-Methyl-D-aspartate (NMDA) antagonists act by an anti-excitotoxic action to provide neuroprotection against acute brain injury, but these agents can also cause toxic effects. In... 		 
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Submitted by ThirdEyeFloond Find all entries from this user
16-01-2008
389.83 Kbytes Hits 22
Keywords: mk-801
Access denied Receptor mechanisms and circuitry underlying NMDA antagonist neurotoxicity (2002)
Mol Psychiatry. 2002;7(1):32-43.

NB Farber, SH Kim, K Dikranian, XP Jiang and C Heinkel

NMDA glutamate receptor antagonists are used in clinical anesthesia, and are being developed as therapeutic agents for preventing neurodegeneration in stroke, epilepsy, and brain trauma. However, the... 		 
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Submitted by ThirdEyeFloond Find all entries from this user
16-01-2008
3.75 Mbytes Hits 6
Keywords: neurotoxicity nmda
Access denied Relative reinforcing strength of three N-methyl-D-aspartate antagonists with different onsets of action (2002)
Journal of Pharmacology and Experimental Therapeutics 2002 May;301(2):690-7

Winger G, Hursh SR, Casey KL, Woods JH.

The potential contribution of onset and duration of pharmacological action to the reinforcing strength of three intravenously delivered N-methyl-D-aspartate antagonists was... 		 
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Submitted by Jatelka Find all entries from this user
06-07-2008
122.61 Kbytes Hits 29
Access denied Selective cognitive impairments associated with NMDA receptor blockade in humans
Rowland LM, Astur RS, Jung RE, Bustillo JR, Lauriello J, Yeo RA. Neuropsychopharmacology 2005;30:633-9.

Hypofunction of the N-methyl-D-aspartate receptor (NMDAR) may be involved in the pathophysiology of schizophrenia. NMDAR
antagonists like ketamine induce schizophrenia-like features in... 		 
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Submitted by Paracelsus Find all entries from this user
05-11-2007
151.32 Kbytes Hits 42
Access denied Serotonergic Agents That Activate 5HT2A Receptors Prevent NMDA Antagonist Neurotoxicity (1998)
Neuropsychopharmacology 1998 Jan;18(1):57-62

Farber NB, Hanslick J, Kirby C, McWilliams L, Olney JW.

Phencyclidine, ketamine, and other agents that block NMDA glutamate receptors trigger a schizophrenia-like psychosis in humans and induce pathomorphological changes in cerebrocortical... 		 
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Submitted by Jatelka Find all entries from this user
30-01-2007
166.95 Kbytes Hits 58
Keywords: ketamine psychosis lsd pcp nmda phencyclidine
 

 
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