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Piperazines Documents

Documents about BZP, TFMPP, mCPP, 5-MeO-BZP

New entries announced in forum Research Chemicals

Allowances: 4.88 Mbytes/4.31 Mbytes used

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Entries

Acute Psychosis Following Ingestion of "Rapture" (2004)

Left click: open entry/Right click: save entry

Australasian Psychiatry 2004 Dec;12(4):406-8

Austin H, Monasterio E.

OBJECTIVES: To describe a brief psychotic episode associated with ingestion of a dietary supplement containing piperazine. METHODS: A case report was undertaken. RESULTS: A 20-year-old man developed a brief psychotic...

Submitted by Jatelka

15-01-2007
64.35 Kbytes Hits 57
Keywords: piperazines psychosis bzp

Benzylpiperazine: A drug of abuse? (2007)

Journal of Psychopharmacology 2007 Nov;21(8):888-94

Johnstone AC, Lea RA, Brennan KA, Schenk S, Kennedy MA, Fitzmaurice PS

N-benzylpiperazine (BZP) is the active ingredient in recreational 'party' or 'p.e.p.' pills, which are used to provide a stimulant, euphoric effect akin to that of...

Submitted by Jatelka

21-08-2008
167.19 Kbytes Hits 36

BZP exposure in Adolescent Rats (Thesis)

An interesting thesis found via google when doing a bit of BZP fact-finding.

The document is a thesis by postgraduate university student Lara Aitchison, from the university of Canterbury (New Zealand). The document is freely available on the internet.

The document details (from a psychology...

Submitted by darkglobe

16-06-2009
726.82 Kbytes Hits 6
Keywords: bzp piperazines

Code of Practice for Restricted Substances (Piperazines)

Code of Practice for Restricted Substances (Piperazines) in NZ - A voluntary code of guidelines

Submitted by ~lostgurl~

11-05-2007
257.92 Kbytes Hits 47
Keywords: bzp piperazines

Collapse, reported seizure- and an unexpected pill (2007)

Lancet 2007 Apr 28;369(9571):1490

Wood DM, Dargan PI, Button J, Holt DW, Ovaska H, Ramsey J, Jones AL

Case report (BZP)

Submitted by turkeyphant

27-04-2007
74.00 Kbytes Hits 90
Keywords: piperazines seizures

Design, synthesis and biological evaluation of piperazine analogues as CB1 cannabinoid receptor ligands

After the CB1 receptor antagonist SR141716 (rimonabant) was previously reported to modulate food intake, CB1 antagonism has been considered as a new therapeutic target for the treatment of obesity. Several series of urea, carbamate, amide, sulfonamide and oxalamide derivatives based on...

Submitted by helikophis

17-05-2009
266.54 Kbytes Hits 9

Effects of "Legal X" piperazine analogs on dopamine and serotonin release in rat brain (2004)

Annals of the New York Academy of Sciences 2004 Oct;1025:189-97

Baumann MH, Clark RD, Budzynski AG, Partilla JS, Blough BE, Rothman RB.

3,4-Methylenedioxymethamphetamine (MDMA) is a popular illicit drug that evokes transporter-mediated release of serotonin (5-HT) and dopamine (DA) from...

Submitted by Jatelka

09-11-2008
80.95 Kbytes Hits 23

Effects of benzylpiperazine derivatives on the acute effects of 3,4-methylenedioxymethamphetamine in rat brain (1993)

Neuroscience Letters 1993 Apr 2;152(1-2):17-20

Hashimoto K

The reduction of 5-hydroxytryptamine (5-HT) in rat brain 3 h after administration of 3,4-methylenedioxymethamphetamine (MDMA) was attenuated significantly by coadministration of benzylpiperazine derivatives (p-nitrobenzylpiperazine,...

Submitted by Pino

03-09-2007
353.54 Kbytes Hits 36
Keywords: bzp mdma neurotoxicity piperazines

Effects of mCPP on the extracellular concentrations of serotonin and dopamine in rat brain (1999)

Neuropsychopharmacology 1999 Mar;20(3):287-96

Eriksson E, Engberg G, Bing O, Nissbrandt H.

Intravenous administration of m-chloro-phenylpiperazine (mCPP) (0.25 or 2.5 mg/kg) induced a marked and dose-related increase in extracellular concentrations of serotonin in hippocampus (300-1,400% of...

Submitted by Jatelka

27-08-2006
284.24 Kbytes Hits 44
Keywords: piperazine mcpp serotonin dopamine

EU: the appearance of mCPP in Slovenia

Submitted by Alfa

30-05-2006
90.12 Kbytes Hits 65
Keywords: mcpp

Europol report on mCPP

Submitted by Alfa

30-05-2006
783.87 Kbytes Hits 44
Keywords: mcpp

Europol–EMCDDA Joint Report on a new psychoactive substance: 1-benzylpiperazine (BZP)

A formal risk-assessment exercise on the drug BZP, carried out by the EMCDDA Scientific Committee with participation of additional experts from the European Commission, Europol and the European Medicines Agency (EMEA), has resulted in a risk-assessment report which was submitted to the European...

Submitted by Lunar Loops

16-06-2007
212.58 Kbytes Hits 28

Europol–EMCDDA Joint Report on a new psychoactive substance: 1-benzylpiperazine (BZP) - Annex 1

Annex 1 of EMCDDA report on BZP detailing information sources used in the study.

Submitted by Lunar Loops

16-06-2007
78.07 Kbytes Hits 31

Europol–EMCDDA Joint Report on a new psychoactive substance: 1-benzylpiperazine (BZP) - Annex 2

Annex 2 of the EMCDDA report showing images of BZP seizures and collected samples.

Submitted by Lunar Loops

16-06-2007
797.99 Kbytes Hits 12

Highs and lows: patterns of use, positive and negative effects of benzylpiperazine-containing party pills (BZP-party pills) amongst young people in New Zealand (2007)

Harm Reduct J. 2007 Nov 19;4:18.

Butler RA, Sheridan JL.

ABSTRACT:

BACKGROUND: This study aimed to investigate patterns and context of use of BZP-party pills, function of use, and positive and negative effects experienced by a sample of New Zealand young people who had used the...

See also By Country/Region Documents

Submitted by Jatelka

01-03-2008
170.29 Kbytes Hits 25
Keywords: bzp party-pills piperazines

In Vivo Metabolism of the New Designer Drug 1-(4-methoxyphenyl)piperazine (MeOPP) in Rat and Identification of the Human Cytochrome P450 Enzymes Responsible for the Major Metabolic Step (2004)

Xenobiotica 2004 Feb;34(2):179-92

Staack RF, Theobald DS, Paul LD, Springer D, Kraemer T, Maurer HH.

1. The in vivo metabolism of 1-(4-methoxyphenyl)piperazine (MeOPP), a novel designer drug, was studied in male Wistar rats. 2. MeOPP was mainly O-demethylated to...

Submitted by Jatelka

23-11-2007
161.72 Kbytes Hits 20
Keywords: piperazine metabolism

Legal party pill use in New Zealand: Prevalence of use, availability, health harms and ‘gateway effects’ of benzylpiperazine and triflourophenylmethylpiperazine

The principal aims of the 2006 National Household Survey of Legal Party Pill Use were to provide national population statistics on the prevalence and patterns of legal party pill use in New Zealand, and to provide data on the harms and problems related to the use of legal party pills in New...

Submitted by Bajeda

09-11-2006
230.97 Kbytes Hits 42
Keywords: bzp tfmpp

Legal Party Pills and Their Use by Young People in New Zealand: A Qualitative Study (2007)

Jane Sheridan and Rachel Buter

An overview of Piperazines in New Zealand

See also By Country/Region Documents

Submitted by Jatelka

11-03-2009
699.86 Kbytes Hits 14

mCPP Dissociates In Vivo Serotonin Release from Long-Term Serotonin Depletion in the Rat Brain (2001)

Neuropsychopharmacology 2001 May;24(5):492-501

Baumann MH, Ayestas MA, Dersch CM, Rothman RB.

Serotonin (5-HT) releasing agents such as d-fenfluramine are known to cause long-term depletion of forebrain 5-HT in animals, but the mechanism of this effect is unknown. In the present study, we...

Submitted by Jatelka

27-08-2006
251.61 Kbytes Hits 27
Keywords: serotonin mcpp

mCPP: an undesired addition to the ecstasy market.

J Psychopharmacol. 2009 Mar 20. [Epub ahead of print]

Bossong M, Brunt T, Van Dijk J, Rigter S, Hoek J, Goldschmidt H, Niesink R.

AbstractA new ecstasy-like substance, meta-chlorophenylpiperazine (mCPP), has been detected in street drugs in the Netherlands. Theoretically, mCPP possesses the...

See also Ecstasy (MDMA, MDEA, MDA) Documents

Submitted by ThirdEyeFloond

03-04-2009
181.36 Kbytes Hits 20

MDMA-like behavioral effects of N-substituted piperazines in the mouse (2007)

Pharmacol Biochem Behav. 2007 Nov;88(1):18-27. Epub 2007 Jul 6

Yarosh HL, Katz EB, Coop A, Fantegrossi WE

Few studies have characterized the subjective effects of N-substituted piperazines, but these drugs show potential for abuse in humans, and have often been associated with MDMA...

Submitted by Jatelka

24-02-2008
806.17 Kbytes Hits 14
Keywords: piperazines

Methamphetamine, Ecstasy and BZP in New Zealand - An Annotated Bibliography

Methamphetamine, Ecstasy and BZP in New Zealand - An Annotated Bibliography

Masters' research paper by Simon Chamberlain, June 2005.

An annotated bibliography of material published in New Zealand on the subject of ecstasy, methamphetamine, or "social tonics" (legal stimulants containing BZP...

See also By Country/Region Documents Drug Policy Debate Documents Methamphetamine Documents Ecstasy (MDMA, MDEA, MDA) Documents

Submitted by Expat98

12-06-2008
873.27 Kbytes Hits 37

N-substituted Piperazines Abused by Humans Mimic the Molecular Mechanism of MDMA (2005)

Neuropsychopharmacology 2005 Mar;30(3):550-60

Baumann MH, Clark RD, Budzynski AG, Partilla JS, Blough BE, Rothman RB.

3,4-Methylenedioxymethamphetamine (MDMA, or 'Ecstasy') is an illicit drug that stimulates the release of serotonin (5-HT) and dopamine (DA) from neurons. Recent evidence...

Submitted by Jatelka

25-03-2006
179.31 Kbytes Hits 54
Keywords: tfmpp mdma bzp

Nephrotoxicity of BZP-based herbal party pills: a New Zealand case report (2006)

N Z Med J. 2006 May 5;119(1233):U1959

Alansari M, Hamilton D

Discussion Thread

Submitted by Jatelka

01-03-2008
75.37 Kbytes Hits 37
Keywords: bzp piperazines toxicity

New designer drug 1-(3-trifluoromethylphenyl) piperazine (TFMPP): gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry studies on its phase I and II metabolism and on its toxicological detection in rat urine (2003)

J Mass Spectrom. 2003 Sep;38(9):971-81.

Staack RF, Fritschi G, Maurer HH

Studies are described on the phase I and II metabolism and the toxicological analysis of the piperazine-derived designer drug 1-(3-trifluoromethylphenyl)piperazine (TFMPP) in rat urine using gas chromatography/mass...

See also Drug Testing Documents

Submitted by Jatelka

01-03-2008
260.40 Kbytes Hits 23
Keywords: drug-testing metabolism tfmpp urine

Party pills – how little is known? (B Russell)

NZFP Volume 33 Number 1, February 2006

Author: Bruce Russell

Submitted by ThirdEyeFloond

22-01-2008
78.89 Kbytes Hits 25
Keywords: bzp tfmpp

Pharmacokinetics of ‘party pill’ drug N-benzylpiperazine (BZP) in healthy human participants

Abstract: There have been many reports of benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP) being used as recreational drugs which have been widely marketed in the form of 'party pills' since the late 1990's. However, there is no information currently available describing the...

Submitted by Gradient

10-06-2009
373.68 Kbytes Hits 7

Piperazine-like compounds: a new group of designer drugs-of-abuse on the European market.

Forensic Sci Int. 2001 Sep 15;121(1-2):47-56.

de Boer D, Bosman IJ, Hidvégi E, Manzoni C, Benkö AA, dos Reys LJ, Maes RA.

1-Aryl-piperazine compounds are, depending on their substituents, selective for certain serotonin receptors and together with their easy availability and their so-called...

Submitted by ThirdEyeFloond

26-05-2009
146.44 Kbytes Hits 4
Keywords: bzp piperazines tfmpp pmeopp

Recreational Drug Using Behaviour and Legal BZP Party Pills (2007)

Kate Bryson and Marc Wilson

Report to The National Drug Policy (New Zealand)

See also By Country/Region Documents

Submitted by Jatelka

11-03-2009
268.47 Kbytes Hits 18

Reinforcing and discriminative stimulus effects of 1-benzylpiperazine and trifluoromethylphenylpiperazine in rhesus monkeys

Drug and Alcohol Dependence, Volume 77, Issue 2, 14 February 2005, Pages 161-168

W.E. Fantegrossi, G. Winger, J.H. Woods, W.L. Woolverton and A. Coop

1-Benzylpiperazine (BZP) and 1-(3-trifluoromethylphenyl)piperazine (TFMPP) are two designer drugs that are often sold in combination tablets...

Submitted by Jatelka

25-01-2008
123.84 Kbytes Hits 14
Keywords: bzp tfmpp

Report on the risk assessment of BZP (2009)

EMCDDA formal risk assessment of BZP

Submitted by Jatelka

09-07-2009
1.09 Mbytes Hits 5

Review of the pharmacotoxicological data on 1-benzylpiperazine (BZP), In: Report on the risk assessment of BZP in the framework of the Council Decision on new psychoactive substances. EMCDDA (in press)

This publication presents the findings of the formal risk assessment on BZP, produced in 2007 by the Scientific Committee of the EMCDDA, with participation of additional experts from the European Commission, Europol and the EMEA. The risk assessment report, which was submitted to the European...

Submitted by Gradient

18-05-2009
1.52 Mbytes Hits 4

STANZ - Proposed Restricted Substance Regulations (BZP)

The Social Tonics Association of New Zealand (STANZ) Proposed Restricted substance Regulations for BZP

Submitted by ~lostgurl~

11-05-2007
187.84 Kbytes Hits 20
Keywords: regulations bzp

Study: BZP ban will create profitable black market (NZ)

2 mins
11 Oct 2007
TV3 News (NZ)

A new study looking at the impact of a ban on BZP shows a black market for the pills could prove to be highly profitable. More than half of the participants were prepared to pay more for party pills once they are made illegal.

Discussion Thread

See also News Coverage Videos About Drugs Drug Policy Debate Documents

Submitted by ~lostgurl~

10-10-2007
34 bytes Hits 195
Keywords: bzp law partypills piperazines

Synthesis and transporter binding properties of bridged piperazine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909).

Journal of Medicinal Chemistry 2000 Dec 14;43(25):4840-9

Zhang Y, Rothman RB, Dersch CM, de Costa BR, Jacobson AE, Rice KC.

A series of analogues related to 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (2) and 1-¿2-[bis(4-fluorophenyl)methoxy]ethyl¿-4-(3-phenylpropyl)piperazine...

Submitted by fnord

07-05-2007
113.58 Kbytes Hits 36

TFMPP may produce its stimulus effects via a 5-HT1B mechanism (1986)

Pharmacology Biochemistry and Behaviour 1986 Jan;24(1):43-7

McKenney JD, Glennon RA

Tests of stimulus generalization were conducted using rats trained to discriminate 1.0 mg/kg of 1-(3-trifluoromethylphenyl)piperazine (TFMPP) from saline in a standard two-lever operant procedure....

Submitted by Jatelka

02-08-2006
406.05 Kbytes Hits 26
Keywords: tfmpp

The benzylpiperazine (BZP) / trifluoromethylphenylpiperazine (TFMPP) and alcohol safety study (2006)

Party pills containing benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP) are used as recreational drugs for their stimulant effects. An estimated 20 million doses of these party pills have been sold legally in New Zealand over the past six years. There is a significant gap in the...

Submitted by Lunar Loops

03-07-2008
551.94 Kbytes Hits 22

The Benzylpiperazine (BZP) and Triflouromethylphenylpiperazine (TFMPP) and Alcohol Safety Study (2006)

Report for The Ministry of Health (New Zealand)

Thompson I, Williams G, Aldington S, Williams M, Caldwell B, Dickson S, Lucas N, Macdowell J, Weatherall M, Frew A, Robinson G, Beasely R

Randomised, double-blind placebo controlled trial comparing the effects of piperazines alone, and in...

See also By Country/Region Documents

Submitted by Jatelka

11-03-2009
551.94 Kbytes Hits 69

THE EXPERT ADVISORY COMMITTEE ON DRUGS (EACD) ADVICE TO THE MINISTER ON: BENZYLPIPERAZINE (BZP) April 2004

Submitted by Alfa

09-04-2006
132.99 Kbytes Hits 63
Keywords: bzp

The prevalence of use, dependency and harms of legal "party pills", containing benzylpiperazine (BZP) and triflourophenylmethylpiperazine (TFMPP) in New Zealand (2007)

Journal of Substance Use, June 2007; 12(3): 213–224

CHRIS WILKINS, MELISSA GIRLING, & PAUL SWEETSUR

See also By Country/Region Documents

Submitted by Jatelka

01-07-2008
181.77 Kbytes Hits 11

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