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Ketamine Documents

Documents about Ketamine, Special K, Ketaject, Ketalar, Ketanest

New entries announced in forum Ketamine

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Entries

"Ketamine Dreams and Realities," by Karl Jansen

Left click: open entry/Right click: save entry

MAPS, the publisher of Karl Jansen's text, Ketamine Dreams and Realities have kindly put it online. Jansen is the leading expert on the recreational use of ketamine. This book is invaluable for anyone interested in vitamin K. Jansen writes about the pharmacology, culture and purported significance...

Submitted by enquirewithin

20-02-2008
1.17 Mbytes Hits 248
Keywords: jansen ketamine lilly vitamin k marcia moore karl

A case of ketamine dependence with discontinuation symptoms (2006)

Addiction 2006 Aug;101(8):1212-3

Critchlow DG

Case Report

Discussion Thread

See also Addiction Documents

Submitted by Jatelka

13-04-2008
50.76 Kbytes Hits 88
Keywords: addiction dependence ketamine withdrawal

A ketamine mixture anesthetic inhibits neuroendocrine and behavioral consequences of cocaine administration (1994)

Published in Brain Research 656 (1994) 33-42.

German Torres, Catherine Rivier, Friedbert Weiss

Cocaine is known to affect different brain systems, particularly those associated with arousal, motor and motivational functions. In order to identify a possible neurochemical link among these...

See also Cocaine & Crack Documents

Submitted by ThirdEyeFloond

15-01-2008
1.01 Mbytes Hits 26
Keywords: ketamine cocaine

A Pediatric Case of Ketamine-associated Cystitis (Letter-to-the-Editor RE: Shahani R, Streutker C, Dickson B, et al: Ketamine-associated Ulcerative Cystitis: A New Clinical Entity.

We would like to report the first case of a pediatric
patient who developed cystitis following the use of oral
ketamine as an adjuvant medication for chronic pain.
Our patient, a 16-year-old female with a complex medical
history, developed complex regional pain syndrome
(CRPS–Type I) about 2...

Submitted by ThirdEyeFloond

28-10-2008
50.91 Kbytes Hits 27
Keywords: ketamine

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression (2006)

Archives of General Psychiatry 2006 Aug;63(8):856-64

Zarate CA Jr, Singh JB, Carlson PJ, Brutsche NE, Ameli R, Luckenbaugh DA, Charney DS, Manji HK.

CONTEXT: Existing therapies for major depression have a lag of onset of action of several weeks, resulting in considerable morbidity....

Submitted by Jatelka

16-01-2007
363.34 Kbytes Hits 90
Keywords: intravenous ketamine antidepressant

A Review of the Non-Medical Use of Ketamine: Use, Users and Consequences (2000)

Journal Of Psychoactive Drugs 2000 Oct-Dec;32(4):419-33

Jansen KL

Ketamine is a dissociative anesthetic with an accepted place in human medicine. Ketamine also has psychedelic properties, and there has been a recent increase in nonmedical use linked with the growth of the "dance culture."...

Submitted by Jatelka

20-11-2007
1.48 Mbytes Hits 31
Keywords: abuse ketamine history club-drugs

A Study on the Cognitive Impairment and Other Harmful Effects Caused by Ketamine Abuse (2005)

A report by the Narcotics Division, Security Bureau, Hong Kong Special Administrative Region Government

Includes some interesting stuff on the epidemiology of ketamine use in Hong Kong.

Submitted by Jatelka

04-05-2007
722.46 Kbytes Hits 32
Keywords: abuse ketamine memory

Activation of Glutaminergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated With the Pre-Frontal Cortex (1997)

Journal of Neuroscience 1997 Apr 15;17(8):2921-7

Moghaddam B, Adams B, Verma A, Daly D.

Subanesthetic doses of ketamine, a noncompetitive NMDA receptor antagonist, impair prefrontal cortex (PFC) function in the rat and produce symptoms in humans similar to those observed in schizophrenia...

Submitted by Jatelka

20-11-2007
332.81 Kbytes Hits 36
Keywords: ketamine nmda pharmacology dopamine glutamate

Acute and Chronic Effects of Ketamine on Human Memory: A Review (2006)

Psychopharmacology 2006 Nov;188(4):408-24

Morgan CJ, Curran HV

INTRODUCTION: Ketamine is attracting increasing research interest not only because of its powerful amnestic effects but also as a putative model of schizophrenia and as a substance with an expanding following of recreational...

Submitted by Jatelka

02-05-2007
308.73 Kbytes Hits 59
Keywords: ketamine memory

Acute effects of ketamine on memory systems and psychotic symptoms in healthy volunteers

Morgan CJ, Mofeez A, Brandner B, Bromley L, Curran HV. Neuropsychopharmacology 2004 Jan;29(1):208-18.

N-methyl-D-aspartate (NMDA) receptor antagonists have been demonstrated to induce schizophrenia-like symptoms and cognitive impairment in humans. The NMDA receptor has been strongly implicated...

Submitted by Paracelsus

13-11-2007
202.35 Kbytes Hits 30

Acute Ketamine Administration Alters the Brain Responses to Executive Demands ina Verbal Working Memory Task: An fMRI Study (2004)

Neuropsychopharmacology 2004 Jun;29(6):1203-14

Honey RA, Honey GD, O'Loughlin C, Sharar SR, Kumaran D, Bullmore ET, Menon DK, Donovan T, Lupson VC, Bisbrown-Chippendale R, Fletcher PC.

We have used functional MRI to determine the effects of ketamine on brain systems activated in association...

Submitted by Jatelka

02-05-2007
505.37 Kbytes Hits 15
Keywords: ketamine memory neuroimaging

Acute Toxic Effects of Club-Drugs (2004)

Journal of Psychoactive Drugs 2004 Sep;36(3):303-13

Gable RS

This article summarizes the short-term physiological toxicity and the adverse behavioral effects of four substances (GHB, ketamine, MDMA, and Rohypnol) that have been used at latenight dance clubs. The two primary data sources...

See also GHB & GBL Documents Ecstasy (MDMA, MDEA, MDA) Documents Benzodiazepines Documents

Submitted by Jatelka

12-11-2007
1.18 Mbytes Hits 67
Keywords: toxicity ketamine lsd ghb mdma club-drugs

Age-dependent differences in sensitivity and sensitization to cannabinoids and 'club drugs' in male adolescent and adult rats (2008)

Addiction Biology 2008 Sep;13(3-4):277-86

Wiley JL, Evans RL, Grainger DB, Nicholson KL.

Lifelong substance abuse is often initiated during adolescence; yet, most pre-clinical research in this area has been conducted in adult animals. Substantial evidence exists that the brain development...

See also Cannabis Documents Cocaine & Crack Documents Ecstasy (MDMA, MDEA, MDA) Documents

Submitted by Jatelka

24-02-2009
549.99 Kbytes Hits 51

Altered Prefrontal Dopaminergic Function in Chronic Recreational Ketamine Users (2005)

American Journal of Psychiatry 2005 Dec;162(12):2352-9

Narendran R, Frankle WG, Keefe R, Gil R, Martinez D, Slifstein M, Kegeles LS, Talbot PS, Huang Y, Hwang DR, Khenissi L, Cooper TB, Laruelle M, Abi-Dargham A.

OBJECTIVE: Ketamine is a noncompetitive antagonist at the glutamatergic...

Submitted by Jatelka

16-01-2007
182.21 Kbytes Hits 31
Keywords: ketamine dopamine

Anaesthetic Addiction: Ketamine Part 2-- Addictive Psychedelics

An article by the leading authority on non-medical use of ketamine, Karl Jansen. Very informative.

Submitted by enquirewithin

15-01-2009
409.01 Kbytes Hits 58

Antidepressant effect of ketamine during ECT

Ostroff R, Gonzales M, Sanacora G. Am J Psychiatry 2005 Jul;162(7):1386. Letter.

The following case serves to highlight the possible antidepressant effects of ketamine in a patient who unintentionally received an induction dose alone during during two failed ECT [electroconvulsive therapy]...

Submitted by Paracelsus

13-11-2007
63.44 Kbytes Hits 29
Keywords: electroshock

Antidepressant effects of ketamine in depressed patients (2000)

Biological Psychiatry 2000 Feb 15;47(4):351-4

Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, Krystal JH

A growing body of preclinical research suggests that brain glutamate systems may be involved in the pathophysiology of major depression and the mechanism of action of...

Submitted by Bajeda

06-07-2007
51.37 Kbytes Hits 84
Keywords: depression ketamine

Association of Ketamine Induced Psychosis With Activation of the Pre-Frontal Cortex in Healthy Volunteers (1997)

American Journal of Psychiatry 1997 Jun;154(6):805-11

Breier A, Malhotra AK, Pinals DA, Weisenfeld NI, Pickar D.

OBJECTIVE: Agents that antagonize the N-methyl-D-aspartic acid (NMDA) receptor, such as phencyclidine and ketamine, produce an acute psychotic state in normal individuals that...

Submitted by Jatelka

16-08-2006
103.03 Kbytes Hits 35
Keywords: psychosis ketamine

Attenuation of the neuropsychiatric effects of ketamine with lamotrigine: support for hyperglutamatergic effects of N-methyl-D-aspartate receptor antagonists (2000)

Archives of General Psychiatry 2000 Mar;57(3):270-6

Anand A, Charney DS, Oren DA, Berman RM, Hu XS, Cappiello A, Krystal JH.

Background: The cognitive, behavioral, and mood effects of N-methyl-D-aspartate (NMDA) receptor antagonists, such as phencyclidine and ketamine, have been used to...

Submitted by Jatelka

19-06-2008
173.72 Kbytes Hits 16

Behavioral effects of ketamine and toxic interactions with psychostimulants

Hayase T, Yamamoto Y, Yamamoto K. BMC Neuroscience 2006 Mar 16;7:25.

BACKGROUND: The anesthetic drug ketamine (KT) has been reported to be an abused drug and fatal cases have been observed in polydrug users. In the present study, considering the possibility of KT-enhanced toxic effects of other...

Submitted by Paracelsus

13-11-2007
378.22 Kbytes Hits 23

Behavioural Effects of Ketamine and Toxic Interactions with Psychostimulants (2006)

BMC Neuroscience 2006 Mar 16;7:25

Hayase T, Yamamoto Y, Yamamoto K.

BACKGROUND: The anesthetic drug ketamine (KT) has been reported to be an abused drug and fatal cases have been observed in polydrug users. In the present study, considering the possibility of KT-enhanced toxic effects of...

Submitted by Jatelka

13-11-2006
271.06 Kbytes Hits 38
Keywords: toxicity methamphetamine ketamine cocaine

Beyond the K-hole: a 3-year longitudinal investigation of the cognitive and subjective effects of ketamine in recreational users who have substantially reduced their use of the drug (2004)

Addiction. 99(11):1450-1461, November 2004.

Morgan, Celia J. A.; Monaghan, Lisa; Curran, H. Valerie

Abstract:
Rationale: Ketamine is a dissociative anaesthetic that is also a drug of abuse. Previous studies have demonstrated persisting episodic and semantic memory impairments in...

Submitted by Jatelka

06-07-2008
1.08 Mbytes Hits 16

Cellular Mechanisms Underlying the Antidepressant effect of Ketamine (2008)

Biological Psychiatry 2008 Feb 15;63(4):349-52

Maeng S, Zarate CA Jr, Du J, Schloesser RJ, McCammon J, Chen G, Manji HK.

BACKGROUND: Ketamine exerts a robust, rapid, and relatively sustained antidepressant effect in patients with major depression. Understanding the mechanisms underlying the...

Submitted by Evil GIR

24-01-2008
225.63 Kbytes Hits 35

Characteristics and behaviors of ketamine users in France in 2003 (2007)

Journal of Psychoactive Drugs 2007 Mar;39(1):1-11

Reynaud-Maurupt C, Bello PY, Akoka S, Toufik A.

The increase in recreational use of ketamine in France led to the carrying out of a survey aimed at depicting the sociological profiles of French ketamine users, their addictive behaviors, and...

See also By Country/Region Documents

Submitted by Jatelka

06-07-2008
875.58 Kbytes Hits 12

Comfortably Numb

"It started life as an anaesthetic, then became a psychedelic club drug. Now researchers think
ketamine could hold the key to understanding and treating depression, says Erika Check."

From: NATURE|Vol 443|12 October 2006

Submitted by enquirewithin

02-03-2007
642.28 Kbytes Hits 37
Keywords: ketamine antidepressant

Comments on "The Ketamine Model of the Near-Death Experience: A Central Role for the N-Methyl-D-Aspartate Receptor" (1997)

Journal of Near Death Studies 16 (1) Fall 1997

Antonio Bianchi

Submitted by ThirdEyeFloond

15-01-2008
588.10 Kbytes Hits 11
Keywords: ketamine near-death-experience nmda

Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses and cognitive function (2005)

Archives of General Psychiatry 2005 Sep;62(9):985-94

Krystal JH, Perry EB Jr, Gueorguieva R, Belger A, Madonick SH, Abi-Dargham A, Cooper TB, Macdougall L, Abi-Saab W, D'Souza DC.

BACKGROUND: In healthy individuals, ketamine hydrochloride and amphetamine sulfate produce cognitive,...

See also Amphetamine Documents

Submitted by Jatelka

19-06-2008
217.18 Kbytes Hits 51

Comparison of brain metabolic activity patterns induced by ketamine, MK-801 and amphetamine in rats: support for NMDA receptor involvement in responses to subanesthetic dose of ketamine (1999)

Brain Research 1999 Oct 2;843(1-2):171-83

Duncan GE, Miyamoto S, Leipzig JN, Lieberman JA.

Subanesthetic doses of NMDA receptor antagonists induce positive, negative and cognitive schizophrenia-like symptoms in healthy humans and precipitate psychotic reactions in stabilized schizophrenic...

Submitted by ThirdEyeFloond

15-01-2008
1020.43 Kbytes Hits 8
Keywords: nmda ketamine mk-801

Comparison of psychic emergence reactions after (-)-ketamine and (+)-ketamine in mice (2006)

Life Sciences 78 (2006) 1839 – 1844

Jing Liu, Xing-Quan Ji, Xing-Zu Zhu

Ketamine is a racemic mixture containing equal parts of (+)-ketamine and (-)-ketamine. The ketamine enantiomorphs are different in anesthesia and psychic emergence reactions after anesthesia. Therefore, (+)-ketamine was...

Submitted by ThirdEyeFloond

15-01-2008
145.02 Kbytes Hits 17
Keywords: ketamine

Contribution of CY3PA4, CYP2B6 and CYP2C9 Isoforms to n-Demethylation of Ketamine in Human Liver Microsomes (2002)

Drug Metabolism and Disposition 2002 Jul;30(7):853-8

Hijazi Y, Boulieu R

Ketamine is a widely used drug for its anesthetic and analgesic properties; it is also considered as a drug of abuse, as many cases of ketamine illegal consumption were reported. Ketamine is N-demethylated by liver...

Submitted by Jatelka

20-06-2007
146.76 Kbytes Hits 45
Keywords: metabolism ketamine cytochrome

Cortical glutamate–dopamine interaction and ketamine-induced psychotic symptoms in man (2005)

Psychopharmacology 2005 Nov;182(3):375-83

Aalto S, Ihalainen J, Hirvonen J, Kajander J, Scheinin H, Tanila H, Någren K, Vilkman H, Gustafsson LL, Syvälahti E, Hietala J.

RATIONALE: The noncompetitive glutamate N-methyl-D: -aspartate receptor antagonist ketamine induces transient psychotic...

Submitted by Alfa

01-06-2006
194.40 Kbytes Hits 51
Keywords: psychosis ketamine dopamine

Critical Review of Ketamine: World Health Organisation 2006

Looks at pharmacology, pharmacokinetics, toxicity,mechanisms of tolerance and dependence.

Also provides an overview of the literature available ranging from acute effects to long term effects on memory and cognition.

Also provides an overview of therapeutic use.

Submitted by Jatelka

02-05-2007
183.21 Kbytes Hits 43
Keywords: dependence ketamine pharmacokinetics pharmacology tolerance

Cystitis due to the use of ketamine as a recreational drug: a case report

J Med Case Reports. 2008 Jun 26;2:219.

Britt Colebunders and Peter Van Erps

ABSTRACT: INTRODUCTION: Ketamine is a derivative of phencyclidine and is a dissociative anaesthetic. Its use as a recreational drug is on the increase among young adults attending clubs and parties. CASE PRESENTATION:...

Submitted by ThirdEyeFloond

25-07-2008
180.70 Kbytes Hits 28
Keywords: ketamine

Discussion of "The Ketamine Model of the Near-Death Experience: A Central Role for the N-Methyl-D-Aspartate Receptor," by Karl L. R. Jansen (1997)

Journal of Near Death Studies 16 (1) Fall 1997

Stuart W. Twemlow, Glen O. Gabbard

Submitted by ThirdEyeFloond

15-01-2008
503.91 Kbytes Hits 10
Keywords: nmda near-death-experience ketamine

Dissociation of Ketamine Effects on Rule Acquisition and Rule Implementation: Possible Relevance to NMDA Receptor Contributions to Executive Cognitive Functions (2007)

Biological Psychiatry 2000;47 137-143

John H. Krystal, Alexandre Bennett, Danielle Abi-Saab, Aysenil Belger,Laurence P. Karper, D. Cyril D’Souza, Deborah Lipschitz, Anissa Abi-Dargham, and Dennis S. Charney

BACKGROUND: The demands of the Wisconsin Card Sorting Test (WCST) change with...

Submitted by ThirdEyeFloond

15-01-2008
49.99 Kbytes Hits 45
Keywords: ketamine memory nmda

Effect of ketamine on dendritic arbor development and survival of immature GABAergic neurons in vitro

Vutskits L, Gascon E, Tassonyi E, Kiss JZ. Toxicological Sciences 2006;91(2):540-9.

Ketamine, a noncompetitive antagonist of the N-methyl-D-aspartate type of glutamate receptors, was reported to induce neuronal cell death when administered to produce anesthesia in young rodents and monkeys....

Submitted by Paracelsus

13-11-2007
552.18 Kbytes Hits 11
Keywords: dendrite memory

Effects of Different Sub-anaesthetic Doses of Ketamine on Neuropsychology, Psychopathology and State of Consciousness in Man (2005)

Neuropsychobiology 2005;51(4):226-33

Passie T, Karst M, Wiese B, Emrich HM, Schneider U.

This is the first neuropsychological study using the S-enantiomer of the noncompetitive N-methyl-D-aspartate antagonist ketamine. In 2 randomized placebo-controlled trials we studied effects of two...

Submitted by Jatelka

17-01-2007
112.63 Kbytes Hits 54
Keywords: schizophrenia psychosis ketamine

Effects of different subanaesthetic doses of (S)-ketamine on psychopathology and binocular depth inversion in man (2003)

Journal of Psychopharmacology 2003 Mar;17(1):51-6

Passie T, Karst M, Borsutzky M, Wiese B, Emrich HM, Schneider U.

The role of the N-methyl-D-aspartate (NMDA) neurotransmitter system in relation to psychoses is not completely understood, but represent a challenge in neurobiological...

Submitted by Toltec

09-02-2006
69.02 Kbytes Hits 62
Keywords: schizophrenia psychosis ketamine

Effects of Intravenous Ketamine on Explicit and Implicit Measures of Suicidality in Treatment-Resistant Depression

R. Price, M. Nock, D. Charney, S. Mathew

Background
Intravenous ketamine has shown rapid antidepressant effects in early trials, making it a potentially attractive candidate for depressed patients at imminent risk of suicide. The Implicit Association Test (IAT), a performance-based measure of...

Submitted by Gradient

14-09-2009
294.52 Kbytes Hits 4

Effects of Ketamine and Midazolam on Morphine Induced Tolerance and Dependence in Mice (2004)

DARU Vol 12, Number 3, 2004

Habibi and Hassanzadeh

Ketamine decreases tolerance and symptoms of withdrawal. Midazolam does the same.

Submitted by Jatelka

20-11-2007
93.25 Kbytes Hits 22
Keywords: morphine addiction ketamine withdrawal midazolam dependence

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