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Cocaine & Crack Documents

Documents about Cocaine and Crack

New entries announced in forum Cocaine & Crack

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A behavioural economic analysis of alcohol, amphetamine, cocaine and ecstasy purchases by polysubstance misusers. (2004)

Left click: open entry/Right click: save entry

Drug Alcohol Depend. 2004 Oct 5;76(1):93-9

Harry R. Sumnall, Elizabeth Tyler, Graham F. Wagstaff, Jon C. Cole

Behavioural economic models of substance choice describe the relationship between changes in unit price and consumption. As the majority of UK non-dependent substance misusers are...

See also Ecstasy (MDMA, MDEA, MDA) Documents Amphetamine Documents Alcohol Documents Drug Use Documents

Submitted by ThirdEyeFloond

16-01-2008
103.98 Kbytes Hits 303
Keywords: alcohol amphetamine mdma poly-drug polysubstance

A ketamine mixture anesthetic inhibits neuroendocrine and behavioral consequences of cocaine administration (1994)

Published in Brain Research 656 (1994) 33-42.

German Torres, Catherine Rivier, Friedbert Weiss

Cocaine is known to affect different brain systems, particularly those associated with arousal, motor and motivational functions. In order to identify a possible neurochemical link among these...

See also Ketamine Documents

Submitted by ThirdEyeFloond

15-01-2008
1.01 Mbytes Hits 27
Keywords: ketamine cocaine

A Mechanism for the Inhibition of Neural Progenitor Cell Proliferation by Cocaine

A Mechanism for the Inhibition of Neural Progenitor Cell Proliferation by Cocaine

Lee C-T, Chen J, Hayashi T, Tsai S-Y, Sanchez JF, et al.
PLoS Med 5(6): e117.

Prenatal exposure of the developing brain to cocaine causes morphological and behavioral abnormalities. Recent studies indicate that...

Submitted by Expat98

11-06-2008
1.70 Mbytes Hits 24

Age-dependent differences in sensitivity and sensitization to cannabinoids and 'club drugs' in male adolescent and adult rats (2008)

Addiction Biology 2008 Sep;13(3-4):277-86

Wiley JL, Evans RL, Grainger DB, Nicholson KL.

Lifelong substance abuse is often initiated during adolescence; yet, most pre-clinical research in this area has been conducted in adult animals. Substantial evidence exists that the brain development...

See also Cannabis Documents Ketamine Documents Ecstasy (MDMA, MDEA, MDA) Documents

Submitted by Jatelka

24-02-2009
549.99 Kbytes Hits 59

Agranulocytosis after consumption of cocaine adulterated with levamisole

Zhu NY, Legatt DF, Turner AR.
Ann Intern Med. 2009 Feb 17;150(4):287-9.

Letter to the Editor, describing 5 patients who developed agranulocytosis (low white blood cell count). 1 patient also had Hepatitis C

Submitted by Jatelka

01-09-2009
297.23 Kbytes Hits 38

Alpha2-containing GABA(A) receptors are involved in mediating stimulant effects of cocaine (2008)

Pharmacology, Biochemistry and Behaviour 2008 Jul;90(1):9-18

Morris HV, Dawson GR, Reynolds DS, Atack JR, Rosahl TW, Stephens DN.

alpha2 subunit-containing GABA(A) receptors are involved in incentive learning associated with cocaine, and in cocaine addiction. Deletion of alpha2-containing...

Submitted by Jatelka

23-01-2009
500.80 Kbytes Hits 14

Altered levels of sex and stress steroid hormones assessed daily over a 28-day cycle in early abstinent cocaine-dependent females (2008)

Psychopharmacology 2008 Jan;195(4):527-36

Fox HC, Hong KA, Paliwal P, Morgan PT, Sinha R

RATIONALE: There is growing evidence of alterations in brain stress and reward circuits associated with cocaine dependence. Sex differences are also documented and sex steroid hormones have been linked...

See also Cocaine Addiction Documents

Submitted by Jatelka

20-08-2008
199.15 Kbytes Hits 39

An analysis of cocaine powder in the Netherlands: content and health hazards due to adulterants

Aims: To report on trends in the content and adulterants present in street cocaine (powder) in the Netherlands and to describe the associated health hazards.

Design and participants: Drug consumers handed in samples of cocaine powder from 1999 to 2007 for analysis. Reports were compiled of...

Submitted by staples

01-09-2009
161.99 Kbytes Hits 33
Keywords: cocaine

An overview of cocaine use in Ireland (2007)

Report on Cocaine use in Ireland commissioned by the government and produced by the National Advisory Committee on Drugs.

See also By Country/Region Documents

Submitted by Lunar Loops

09-03-2007
958.97 Kbytes Hits 53
Keywords: cocaine drug-use

Antidepressant Drugs Appear to Enhance Cocaine-Induced Toxicity (2000)

Experimental and Clinical Pharmacology 2000 Feb;8(1):133-41

O'Dell LE, George FR, Ritz MC

It has been shown that cocaine-induced convulsions and lethality appear to be mediated by serotonin and dopamine neurotransmission, respectively. However, many antidepressants considered for treatment...

Submitted by Bajeda

11-08-2006
801.66 Kbytes Hits 79
Keywords: cocaine toxicity antidepressant

Behavioral effects of novel cocaine analogs: a comparison with in vivo receptor binding potency (Cline et al 1992)

Volume 260, Issue 3, pp. 1174-1179, 03/01/1992

EJ Cline, U Scheffel, JW Boja, FI Carroll, JL Katz and MJ Kuhar

Several novel cocaine analogs, previously shown to be very potent in in vitro binding studies, have been examined for their stimulatory effects on locomotor activity and for their...

Submitted by ThirdEyeFloond

01-09-2008
1.32 Mbytes Hits 33

Behavioural and Neurochemical Responses to Cocaine in Periadolescent and Adult Rats (2007)

Neuropsychopharmacology 2007 Mar;32(3):625-37

Frantz KJ, O'Dell LE, Parsons LH.

Although recreational drug use by human adolescents is a well-known and long-standing problem, relatively little is known regarding differences in behavioral and physiological responses to abused substances in...

Submitted by Jatelka

18-05-2007
215.44 Kbytes Hits 77
Keywords: cocaine

Cardiovascular Complications of Cocaine Use (2001)

New England Journal of Medicine 2001 Aug 2;345(5):351-8

Lange RA, Hillis LD

Submitted by Jatelka

16-01-2007
222.73 Kbytes Hits 143
Keywords: cocaine

Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs

Abstract: Substance abuse and addiction are the most costly of all the neuropsychiatric disorders. In the last decades, much progress has been achieved in understanding the effects of the drugs of abuse in the brain. However, efficient treatments that prevent relapse have not been developed. Drug...

See also Opium, Opiate & Opioids Documents Pharmacology Documents Amphetamine Documents

Submitted by Gradient

19-07-2009
569.08 Kbytes Hits 34

Cerebellar Vermis Involvement in Cocaine Related Behaviours (2006)

Neuropsychopharmacology 2006 Jun;31(6):1318-26

Anderson CM, Maas LC, Frederick B, Bendor JT, Spencer TJ, Livni E, Lukas SE, Fischman AJ, Madras BK, Renshaw PF, Kaufman MJ.

Although the cerebellum is increasingly being viewed as a brain area involved in cognition, it typically is excluded...

Submitted by Jatelka

15-08-2006
190.39 Kbytes Hits 73
Keywords: cocaine

Closing and Inactivation Potentiate the Cocaethylene Inhibition of Cardiac Sodium Channels by Distinct Mechanisms

a study of some of the effects of cocaethylene on the cardio. system

Submitted by Benga

22-11-2008
308.21 Kbytes Hits 11
Keywords: cocaethylene

Coca and Cocaine As Medicines: An Historical Review (1981)

Journal of Ethnopharmacology 1981 Mar-May;3(2-3):149-59.

Grinspoon L, Bakalar JB.

Coca has been used in folk medicine in South America for thousands of years both as a general stimulant and for more specific medical purposes. It remains one of the most commonly used medicines in some areas...

See also Drug History Documents

Submitted by Bajeda

19-04-2007
1008.64 Kbytes Hits 38
Keywords: medicine coca cocaine history

Coca leaf chewing as therapy for cocaine maintenance (2000)

Ann Med Interne (Paris). 2000 Oct;151 Suppl B:B44-8.

Jorge Hurtado-Gumucio

Major ethnic groups in Bolivia (Aymaras and Quechuas) have chewed the coca leaf for generations upon generations without health problems. The effects of coca leaf chewing produce a level of social and economic...

See also Coca Documents

Submitted by ThirdEyeFloond

16-01-2008
22.18 Kbytes Hits 168
Keywords: addiction coca cocaine dependence

Cocaethylene Metabolism and Interaction with Cocaine and Ethanol: Role of Carboxylesterase (2003)

Drug Metabolism and Disposition 2003 Jan;31(1):16-20

Laizure SC, Mandrell T, Gades NM, Parker RB.

Carboxylesterases are important in the metabolism of cocaine, catalyzing the hydrolysis of cocaine to its two major metabolites, benzoylecgonine and ecgonine methyl ester. In the presence of...

Submitted by Jatelka

18-05-2007
77.77 Kbytes Hits 125
Keywords: metabolism cocaine cocaethylene alcohol

Cocaine 1of3 - Viva La Coca.avi

Three dramatic and intimate films about cocaine, taking viewers on a chilling journey from the coca fields and cocaine producers of the Peruvian Andes, via drugs gangs in the favelas of Rio, to the man who stands behind over half of Colombia’s drug trade.

This trilogy presents the drug as a...

Submitted by _caesar_

10-11-2006
Hits 519
Keywords: coca cocaine

Cocaine 2of3 - Leo and Ze.avi

Framed by extraordinary access to the drugs gangs in Rio, programme two, Leo and Ze, is a brutal and unsettling story of violence, poverty and wasted lives. Ze, a reformed gang leader, tries to help his nephew Leo to do the same. Filmed over several months, the film features explicit footage of...

Submitted by _caesar_

18-11-2006
Hits 290
Keywords: coca cocaine

Cocaine and Alcohol Interactions in Humans: NeuroEndocrine Effects and Cocaethylene Metabolism (1997)

Journal of Pharmacology and Experimental Therepeutics 1997 Oct;283(1):164-76

Farré M, de la Torre R, González ML, Terán MT, Roset PN, Menoyo E, Camí J.

The effects of 100 mg of intranasal cocaine in acute alcohol intoxication (0.8 g/kg) were evaluated in eight experienced and nondependent...

Submitted by Jatelka

08-08-2006
386.85 Kbytes Hits 204
Keywords: metabolism alcohol cocaine cocaethylene interactions

Cocaine and heroin ('speedball') self-administration: the involvement of nucleus accumbens dopamine and mu-opiate, but not delta-opiate receptors (2005)

Psychopharmacology (Berl). 2005 Jun;180(1):21-32

Cornish JL, Lontos JM, Clemens KJ, McGregor IS

RATIONALE: The combined administration of heroin and cocaine ('speedball') is common among intravenous drug users. Dopamine receptors in the nucleus accumbens play a key role in cocaine...

See also Heroin Documents

Submitted by Jatelka

24-02-2008
410.48 Kbytes Hits 67
Keywords: cocaine heroin intravenous speedball

Cocaine and it's Adulterants Solubilities

An excel spreadsheet containing a table of cocaine and various common cutting agents and their solubilites in various chemicals, especially water, acetone and chloroform. Copied from 'The Cocaine Users Handbook', by David Lee.

Submitted by Aar0n

11-07-2008
25.50 Kbytes Hits 247

Cocaine and methamphetamine produce different patterns of subjective and cardiovascular effects.

Pharmacol Biochem Behav. 2005 Sep;82(1):90-7. Epub 2005 Aug 19.

Newton TF, De La Garza R 2nd, Kalechstein AD, Nestor L.

The stimulant effects of cocaine and methamphetamine are mediated by changes in synaptic concentrations of brain monoamines; however, the drugs alter monoamine levels via...

See also Methamphetamine Documents

Submitted by ThirdEyeFloond

27-05-2009
147.61 Kbytes Hits 24
Keywords: cocaine methamphetamine

Cocaine and opioid use during pregnancy: prevalence and management (2008)

Primary Care Companion to the Journal of Clinical Psychiatry

Bhuvaneswar CG, Chang G, Epstein LA, Stern TA

Looks at epidemiology, effects of cocaine and opiates on the foetus and mother and psychological aspects of substance use during pregnancy

See also Opium, Opiate & Opioids Documents Drug Use Documents

Submitted by Jatelka

09-07-2009
204.26 Kbytes Hits 30

Cocaine and the Critical Care Challenge (2003)

Critical Care Medicine 2003 Jun;31(6):1851-9

Shanti CM, Lucas CE.

OBJECTIVE: Cocaine, which first made its appearance >1,000 yrs ago, is now widely used throughout the world. The physiologic responses to cocaine may cause severe pathologic effects. This review highlights the many critical...

Submitted by Bajeda

11-08-2006
1.05 Mbytes Hits 37
Keywords: cocaine toxicity

Cocaine and thrombosis: a narrative systematic review of clinical and in-vivo studies (2007)

Substance Abuse Treatment, Prevention and Policy 2007 Sep 19;2:27

Wright NM, Martin M, Goff T, Morgan J, Elworthy R, Ghoneim S.

ABSTRACT: PURPOSE: To systematically review the literature pertaining to the link between cocaine and either arterial or venous thrombosis. PROCEDURES: Narrative...

Submitted by Jatelka

29-09-2008
154.75 Kbytes Hits 23

Cocaine associated priapism (1999)

J Urol. 1999 Jun;161(6):1817-8

Altman AL, Seftel AD, Brown SL, Hampel N

PURPOSE: Cocaine abuse is an ongoing epidemic in the United States. Priapism associated with cocaine use has been reported only twice in the urological literature. To our knowledge we report the first series of priapism...

Submitted by fnord

13-10-2008
111.44 Kbytes Hits 29

Cocaine Cardiovascular Toxicity (2005)

Southern Medical Journal 98, 8, August 2005

Steven B Karsch

Cocaine puts enormous strain on the heart.

You are more likely to die from Cocaine use after you have been using it for a time rather than when you first start using it... i.e. the negative effects of cocaine on the...

Submitted by Bajeda

11-08-2006
352.63 Kbytes Hits 149
Keywords: toxicity cocaine

Cocaine Esterase Prevents Cocaine-Induced Toxicity and the Ongoing Intravenous Self-Administration of Cocaine in Rats (2009)

J Pharmacol Exp Ther November 2009 331:445-455; published ahead of print August 26, 2009, doi:10.1124/jpet.108.150029

Abstract
Cocaine esterase (CocE) is a naturally occurring bacterial enzyme, is a very efficient protein catalyst for the hydrolysis of cocaine, and has previously been shown to...

See also Addiction Documents

Submitted by staples

02-01-2010
1.27 Mbytes Hits 2
Keywords: cocaine coce

Cocaine in surface waters: a new evidence-based tool to monitor community drug abuse (2005)

Environmental Health 2005 Aug 5;4:14

Zuccato E, Chiabrando C, Castiglioni S, Calamari D, Bagnati R, Schiarea S, Fanelli R.

Cocaine use seems to be increasing in some urban areas worldwide, but it is not straightforward to determine the real extent of this phenomenon. Trends in drug abuse...

See also Drug Use Documents

Submitted by Bajeda

14-06-2007
350.21 Kbytes Hits 42
Keywords: cocaine use

Cocaine pharmacokinetics in men and in women during the follicular and luteal phases of the menstrual cycle (1999)

Neuropsychopharmacology 1999 Aug;21(2):294-303

Mendelson JH, Mello NK, Sholar MB, Siegel AJ, Kaufman MJ, Levin JM, Renshaw PF, Cohen BM.

Preclinical and clinical studies suggest that females may be less vulnerable to cocaine's toxic effects than males. The pharmacokinetics of intravenous...

Submitted by Jatelka

03-06-2009
182.15 Kbytes Hits 12

Cocaine Sensitisation: Modulation by Dopamine D2 Receptors (2002)

Cerebral Cortex May 2002, 12, 526-535

Beyer C and Sketetee J

Submitted by Jatelka

15-08-2006
334.38 Kbytes Hits 56
Keywords: cocaine dopamine

Cocaine Toxicity: Genetic Differences in Cocaine-Induced Lethality in Rats (1991)

Pharmacology Biochemistry and Behaviour 1991 Apr;38(4):893-5

George FR

Cocaine produces stimulation, depression, convulsions and death, and binds at several receptor sites. Thus cocaine may produce toxicity through similar or distinct pathways from those associated with stimulation. Genetic...

Submitted by Bajeda

11-08-2006
316.74 Kbytes Hits 56
Keywords: toxicity cocaine

Cocaine: recent trends in Northern Ireland (2009)

The Ulster Medical Journal 2009 May;78(2):94-8

Lyness JR

A review of autopsy reports in cases in which cocaine featured in the cause of death in Northern Ireland revealed that there were 18 deaths between 1(st) January 1999 and 31(st) December 2007. Analysis revealed an increasing incidence...

See also By Country/Region Documents

Submitted by Jatelka

09-07-2009
299.18 Kbytes Hits 12

Comparative cardiac pathology among deaths due to cocaine toxicity, opioid toxicity and non-drug-related causes (2006)

Addiction 2006 Dec;101(12):1771-7

Darke S, Kaye S, Duflou J.

AIM: To compare cardiac and cerebrovascular pathology among deaths due to cocaine toxicity, deaths due to opioid toxicity and deaths from hanging that were toxicologically negative for cocaine/opioids. DESIGN: Case-control....

Submitted by Jatelka

13-04-2008
82.75 Kbytes Hits 37
Keywords: cocaine cardiotoxicity

Comparative Lethality of Coca and Cocaine (1982)

Pharmacology Biochemistry and Behaviour 1982 Nov;17(5):1087-8

Bedford JA, Turner CE, Elsohly HN.

The 24 hour lethal effects of cocaine were compared to those of a crude ethanol extract of the coca leaf (Erthroxyhm coea) in male, Swiss mice. Various doses of cocaine HCI and coca leaf...

See also Coca Documents

Submitted by Bajeda

19-04-2007
119.96 Kbytes Hits 116
Keywords: toxicity cocaine coca

Comparative Stimulant Properties of Two Fractions of the Coca Leaf (E. coca) (1981)

Pharmacology Biochemistry and Behaviour 1981 Dec;15(6):907-9

Bedford JA, Nail GL, Elsohly HN, Wilson MC, Turner CE.

Male and female Wistar rats were trained to discriminate 5.0 mg/kg cocaine from 2.0 ml/kg saline using a two-bar food reinforcement (FR 30) drug discrimination paradigm. Once...

See also Coca Documents

Submitted by Bajeda

19-04-2007
268.32 Kbytes Hits 79
Keywords: stimulant cocaine coca

Contributions of Dopamine D1, D2, and D3 Receptor Subtypes to the Disruptive Effects of Cocaine on Prepulse Inhibition in Mice (2007)

Neuropsychopharmacology e-published Dec 2007

Doherty JM, Masten VL, Powell SB, Ralph RJ, Klamer D, Low MJ, Geyer MA.

Deficits in prepulse inhibition (PPI) of startle, an operational measure of sensorimotor gating, are characteristics of schizophrenia and related neuropsychiatric disorders....

Submitted by Jatelka

19-04-2008
158.30 Kbytes Hits 22
Keywords: cocaine dopamine

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