File Archive - Research Chemicals Documents

News Groups Blog Forum Chat Video Audio Images Documents Wiki Home

		Drugs Forum > File Archive > Documents > CHEMICAL & (SEMI-) SYNTHETIC DRUGS
Research Chemicals Documents

Tags

FAQ n Rules

Mark Forums Read

Notices

Create a FREE account now to get access to more forums, more videos, more music, more documents, more images, more reviews, more news about drugs and much more functionality.
Start posting now, join our groups or create your unique profile.

links

Research Chemicals Documents

Documents about RC's, Research Chemicals

New entries announced in forum Research Chemicals

Allowances: 4.88 Mbytes/0 bytes used

[RSS Feed]

Categories

Cannabinoids Documents [177 entries]

Mephedrone & other Beta-ketones Documents [9 entries]

Phenethylamines Documents [112 entries]

Piperazines Documents [41 entries]

Tryptamines Documents [56 entries]

Page 1 of 2

Entries

"Research chemicals": tryptamine and phenethylamine use among high-risk youth (2008)

Left click: open entry/Right click: save entry

Substance Use and Misuse 2008;43(3-4):389-402

Sanders B, Lankenau SE, Bloom JJ, Hathazi D.

Tryptamines and phenethylamines are two broad categories of psychoactive substances with a long history of licit and illicit use. Profiles of users of recently emerging tryptamines and phenethylamines...

See also Drug Use Documents

Submitted by Jatelka

19-09-2008
311.05 Kbytes Hits 98

(+/-)-1-(2,5-dimethoxy-4-ethylthiophenyl)-2-Aminopropanone (ALEPH-2), a Novel Putative Anxiolytic Agent Lacking Affinity for Benzodiazepine Receptors and 5-HT1A Receptors (Reyes-Perada et al, 1996)

Originally published in The Archives of Pharmacology

The mechanism of action and anxiolytic properties of ALEPH-2 are discussed

Submitted by Jatelka

09-05-2007
765.05 Kbytes Hits 72
Keywords: aleph-2 benzodiazepines anxiolytic

1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors

Meltzer PC, Butler D, Deschamps JR, Madras BK

Abstract: Dopamine, serotonin, and norepinephrine are essential for neurotransmission in the mammalian system. These three neurotransmitters have been the focus of considerable research because the modulation of their production and their interaction...

Submitted by Gradient

28-07-2009
434.00 Kbytes Hits 24

11C-WIN 35,428 for detecting dopamine depletion in mild Parkinson's disease

Madras BK. Annals of neurology. 1994;35(3).

In the September 1993 issue of Annals. an article entitled “Positron Emission Tomographic Imaging of the Dopamine Transporter with ”C-WIN 35,428 Reveals Marked Decline in Mild Parkinson’s Disease” (Frost et al, Ann Neurol 1993; 14:423) was printed as...

Submitted by staples

21-09-2009
253.12 Kbytes Hits 6
Keywords: win-35428

5-Methoxy-N,N-Diisopropyltryptamine-Induced Flashbacks (2005)

American Journal of Psychiatry 2005 Apr;162(4):815

Ikeda A, Sekiguchi K, Fujita K, Yamadera H, Koga Y

Case Report

Submitted by Bajeda

21-08-2006
1.27 Mbytes Hits 54
Keywords: hppd flashback 5-meo-dipt

970 Million Druglike Small Molecules for Virtual Screening in the Chemical Universe Database GDB-13

Paper from American Chemical Society, retrieved for this news thread The paper is two pages. The .zip file contains the paper as two separate .gif files.

One of the most important chemical issues in drug discovery is innovation, in particular at the level of small organic fragments that can...

Submitted by Johan73

07-07-2009
283.04 Kbytes Hits 19
Keywords: chemistry drug drug-research research-chemicals

A general approach to the screening and confirmation of tryptamines and phenethylamines by mass spectral fragmentation (B. Chena et al. 2007)

Talanat 74 (2008) 512-517

Authors: Bo-Hong Chena, Ju-Tsung Liu, Wen-Xiong Chena, Hung-Ming Chena, Cheng-Huang Lin

See also Drug Testing Documents

Submitted by ThirdEyeFloond

18-01-2008
483.32 Kbytes Hits 54
Keywords: phenethylamines tryptamines

A Novel (Benzodifuranyl)aminoalkane with Extremely Potent Activity at the 5-HT2A Receptor

A major focus of our research for a number of years
has been to understand the structure-activity relationship
(SAR) of classical hallucinogens and their derivatives,
the pharmacological action of which is believed
to be mediated primarily by agonist activity at the
serotonin 5-HT2A...

See also Chemistry of other drugs

Submitted by trptamene

10-11-2007
37.37 Kbytes Hits 90

A Parkinsonian Syndrome in Methcathinone Users and the Role of Manganese (2008)

New England Journal of Medicine Volume 358:1009-1017 March 6, 2008 Number 10

Ainars Stepens, M.D., Inara Logina, Ph.D., Viesturs Liguts, Ph.D., Pauls Aldin, M.D., Ilze Eksteina, M.D., Ardis Platkajis, Ph.D., Inese Martinsone, M.Sci., Elmars Terauds, M.D., Baiba Rozentale, Ph.D., and Michael...

Submitted by Jatelka

12-03-2008
346.36 Kbytes Hits 60
Keywords: parkinsonism manganese methcathinone toxcity

An Opioid Agonist that Does Not Induce Opioid Receptor-Arrestin Interactions or Receptor Internalization

C. E. Groer, K. Tidgewell, R. A. Moyer, W. W. Harding, R. B. Rothman, T. E. Prisinzano, and L. M. Bohn

G protein-coupled receptor desensitization and trafficking are important regulators of opioid receptor signaling that can dictate overall drug responsiveness in vivo. Furthermore, different...

See also Opium, Opiate & Opioids Documents

Submitted by Gradient

27-09-2009
487.84 Kbytes Hits 11

Arylalkylamine drugs of abuse: an overview of drug discrimination studies (1999)

Pharmacol Biochem Behav. 1999 Oct;64(2):251-6

Glennon RA.

Abused arylalkylamines fall into two major categories: the indolealkylamines, and the phenylalkylamines: These agents can be further subclassified on the basis of chemical structure. Examples of these agents possess hallucinogenic,...

Submitted by Jatelka

27-01-2008
163.12 Kbytes Hits 58
Keywords: arylalkylamines indolealkylamines phenylalkylamines

Behavioural Effects of the Putative Anxiolytic (+/-)-1-(2,5-dimethoxy-4-ethylthiophenyl)-2-Aminopropanone (ALEPH-2) in Rats and Mice (1996)

Pharmacology Biochemistry and Behaviour 1996 Jun;54(2):355-61

Scorza MC, Reyes-Parada M, Silveira R, Viola H, Medina JH, Viana MB, Zangrossi H Jr, Graeff FG.

Behavioral effects of the phenethylamine derivative (+/-)-1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2) were studied...

Submitted by Jatelka

09-05-2007
491.30 Kbytes Hits 56
Keywords: aleph-2

Benzofuran Bioisosteres of Hallucinogenic Tryptamines

The benzofuran analogues of the hallucinogens 5-methoxy-N,N-dimethyltryptaminaen d 5-methoxy-cy-methyltryptamine
were synthesized and evaluated for affinity at the serotonin 5-HTz and 5-HT1r~e ceptors in rat brain
homogenate, labeled with [1~I]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoprop(a [1ne2...

See also Chemistry of other drugs

Submitted by trptamene

10-11-2007
562.85 Kbytes Hits 48

bk-MBDB MSDS

a material data safety sheet for 2-methylamino-1-(3,4-methylenedioxyphenyl)-butan-1-one aka bk-MBDB aka Butylone

Submitted by Terrapinzflyer

06-11-2009
669.72 Kbytes Hits 12
Keywords: bk-mbdb data material msds safety sheet butylone

Cathinone: An Investigation of Several N-Alkyl and Methylenedioxy-Substituted Analogs

Pharmacol Biochem Behav. 1997 Dec;58(4):1109-16

Dal Cason TA, Young R, Glennon RA.

Structurally, methcathinone is to cathinone what methamphetamine is to amphetamine. Due to increased interest in the abuse of such agents we wished to determine if certain derivatives of cathinone would...

Submitted by Alfa

25-06-2006
86.93 Kbytes Hits 306
Keywords: methylone cathinone

Chemistry, Pharmacology, Toxicology and Hepatic Metabolism of Designer Drugs of the Amphetamine Ecstasy Piperazine and Pyrrolidinophenone Types

Therapeutic Drug Monitoring 2004 Apr;26(2):127-31.

Maurer HH, Kraemer T, Springer D, Staack RF.

Designer drugs of the amphetamine type (eg, MDMA, MDEA, MDA), of the new benzyl or phenyl piperazine type (eg, BZP, MDBP, mCPP, TFMPP, MeOPP), or of the pyrrolidinophenone type (eg, PPP, MOPPP,...

Submitted by Alfa

30-05-2006
117.43 Kbytes Hits 233
Keywords: amphetamine piperazine mdma

Clinical and preclinical PET correlates of parkinsonism with 11C-WIN 35,428

Isacson O. Annals of neurology. 1994;35(3).

The study of and therapy for Parkinson's disease (PD)would be much helped by predictive positron emission tomographic (PET) imaging before the appearance of parkinsonian symptoms so that preventive treatment could be initiated during the early stages...

Submitted by staples

21-09-2009
244.46 Kbytes Hits 6
Keywords: win-35428

Combined Intoxication With Methylone And 5-MeO-MIPT (2007)

Progress in Neuropsycgopharmacology and Biological Psychiatry 2007 Jan 30;31(1):288-91

Shimizu E, Watanabe H, Kojima T, Hagiwara H, Fujisaki M, Miyatake R, Hashimoto K, Iyo M.

We describe a 27-year-old male patient with substance intoxication after a single ingestion of the mixture of...

Submitted by Bajeda

31-08-2006
196.07 Kbytes Hits 177
Keywords: 5-meo-mipt methylone

Deaths Associated With MBDB Misuse (2000)

The International Journal of Legal Medicine 2000;113(3):168-70

Carter N, Rutty GN, Milroy CM, Forrest AR.

The use of phenethylamines in the dance scene is now well established. Apart from amphetamine, the commonest phenethylamine encountered in clinical and forensic settings is...

Submitted by Jatelka

01-02-2007
24.33 Kbytes Hits 101
Keywords: mbdb

Designer Drugs That Are Potent Inhibitors of CYP2D6 (D Pritzker et al 2002)

Journal of Clinical Psychopharmacology 2002 Jun;22(3):330-2.

Authors: David Pritzker, Anish Kanungo, Tansel Kilicarslan, Rachel F. Tyndale and Edward M. Sellers

See also Pharmacology Documents

Submitted by ThirdEyeFloond

23-01-2008
172.53 Kbytes Hits 82
Keywords: cytochrome

Drug Trends & New Designer Drugs

Whilst the classical drugs of abuse remain the main-stay of the market the constant search for new legal and illegal highs has lead to an increase in abuse of novel designer drugs. These new stimulants may be derivatives of amfetamines, but a group of mild stimulants called piperazines has spread...

Submitted by shadowchaser

01-10-2009
1.25 Mbytes Hits 176

Effect of 8-hydroxy-2-(N,N-di-n-propylamino)tetralin and MDMA on the discriminative stimulus effects of the classical hallucinogen DOM in rats

Pharmacol Biochem Behav. 2008 Aug 17. [Epub ahead of print]

Nantaka Khoranaa, Richard Younga and Richard A. Glennon

Abstract

Co-administration of the 5-HT1A serotonin receptor agonist (±)8-hydroxy-2-(N,N-di-n-propylamino)tetralin [(±)8-OH DPAT] enhances the discriminative stimulus effects...

See also Ecstasy (MDMA, MDEA, MDA) Documents

Submitted by ThirdEyeFloond

09-11-2008
647.45 Kbytes Hits 18
Keywords: dom dpat hallucinogens mdma

Effects of long-term biogenic amine transporter blockade on receptor/G-protein coupling in rat brain

Kerry Ann O'Connora, Timothy C. Greggb, Huw M.L. Daviesb and Steven R. Childersa

This study examines the effect of long-term elevation of brain monoamine levels on receptor/G-protein coupling by chronic administration of a highly potent tropane analog, WF-23 (2β-propanoyl-3β-(2-naphthyl)...

Submitted by Gradient

14-08-2009
2.58 Mbytes Hits 6

EU: Early-warning system on new synthetic drugs

Submitted by Alfa

30-05-2006
196.08 Kbytes Hits 135
Keywords: drugs

Functional Selectivity of Hallucinogenic Phenethylamine and Phenylisopopylamine Derivatives at Human 5HT-2a and 5HT-2c Receptors (2007)

Journal of Pharmacology and Experimental Therapeutics 2007 Jun;321(3):1054-61

Moya PR, Berg KA, Gutiérrez-Hernandez MA, Sáez-Briones P, Reyes-Parada M, Cassels BK, Clarke WP.

2,5-Dimethoxy-4-substituted phenylisopropylamines and phenethylamines are 5-hydroxytryptamine (serotonin)...

Submitted by Jatelka

11-08-2007
280.54 Kbytes Hits 92
Keywords: 2c-h 5ht-2c hallucinogens 2c-i 2c-d tma doi dom 5ht-2a serotonin 2c-b

High-affinity binding of [125I]RTI-55 to dopamine and serotonin transporters in rat brain

Boja JW, Mitchell WM, Patel A, Kopajtic TA, Carroll FI, Lewin AH, Abraham P, Kuhar MJ

RTI-55 (3 beta-(4-iodophenyl)tropan-2 beta-carboxylic acid methyl ester), one of the most potent inhibitors of dopamine uptake reported to date, was radioiodinated and tested as a probe for the cocaine receptor...

Submitted by Gradient

20-08-2009
3.20 Mbytes Hits 5

Identification of cytochrome p450 enzymes involved in the metabolism of 4'-methyl-alpha-pyrrolidinopropiophenone, a novel scheduled designer drug, in human liver microsomes (2003)

Drug Metab Dispos. 2003 Aug;31(8):979-82.

Springer D, Paul LD, Staack RF, Kraemer T, Maurer HH.

4'-Methyl-alpha-pyrrolidinopropiophenone (MPPP) is a new drug of abuse. It is believed to have an abuse potential similar to that of amphetamines. Previous studies with Wistar rats had shown...

Submitted by Jatelka

01-03-2008
87.68 Kbytes Hits 53
Keywords: pharmacology mppp cytochrome

Identification of N-Methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine (MBDB), an Homologue Derivative of "Ecstasy" (1999)

Analusis 1999 27 523-532

Baudat Ph, Vicherat A, Viriot ML and Carre MC

Looks at the forensic analysis of MDMA, MDEA, MBDB and EBDB.

Submitted by Jatelka

31-07-2007
102.43 Kbytes Hits 75
Keywords: mdma mdea mbdb

Identification of N-Methyl-4-(3,4-Methylenedioxyphenyl)Butan-2-Amine, Distributed as MBDB (2006)

The Journal of Health Science 52(6) 805-810 (2006)

Matsumoto et al

MDP-3-MB, HMDMA is being sold as MBDB on the Japanese RC scene

Submitted by Jatelka

31-07-2007
266.79 Kbytes Hits 76
Keywords: hmdma mbdb research-chemicals

Illicit cathinone ("Hagigat") poisoning (2008)

Clinical Toxicology 2008 Mar;46(3):206-10.

Bentur Y, Bloom-Krasik A, Raikhlin-Eisenkraft B.

INTRODUCTION: Khat leaves (mainly cathinone and cathine) have been chewed for centuries as stimulants. Hagigat (capsules of 200 mg cathinone) have been marketed in Israel as a natural stimulant and...

Submitted by Jatelka

14-01-2008
71.72 Kbytes Hits 77
Keywords: khat cathinone

In vivo metabolism of 2,5-dimethoxy-4-propylthiophenethylamine (2C-T-7) in rat

The in vivo metabolism of 2,5-dimethoxy-4-propylthiophenethylamine (2C-T-7), a ring-substituted psychoactive phenethylamine, was studied in rat. Male Wistar rats were administered 10 mg/kg 2C-T-7 hydrochloride orally, and 24-h urine fractions were collected. After enzymatic hydrolysis of the urine...

See also Pharmacology Documents

Submitted by Shampoo

29-07-2009
323.19 Kbytes Hits 11
Keywords: 2c-t-7

Inhibition of plasma membrane monoamine transporters by beta-ketoamphetamines (1999)

European Journal of Pharmacology 1999 Sep 17;381(1):63-9

Cozzi NV, Sievert MK, Shulgin AT, Jacob P 3rd, Ruoho AE.

Methcathinone and methylone, the beta-ketone analogues of methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA), respectively, were tested for neurotransmitter uptake...

Submitted by Alfa

25-06-2006
73.08 Kbytes Hits 122
Keywords: catecholamine methylone

Metabolism and toxicological detection of the new designer drug 3',4'-methylenedioxy-alpha-pyrrolidinopropiophenone studied in urine using gas chromatography-mass spectrometry

Springer D, Fritschi G, Maurer HH

Abstract: R,S-3'.4'-Methylenedioxy-alpha-pyrrolidinopropiophenone (MDPPP) is a new designer drug with assumed amphetamine-like effects. which has appeared on the illicit drug market. The aim of this study was to identify the MDPPP metabolites using solid-phase...

Submitted by Gradient

28-07-2009
922.34 Kbytes Hits 7

Metabolism of Designer Drugs of Abuse (RF Staack & HH Maurer 2005)

Current Drug Metabolism, 2005, 6, 259-274

Authors: Roland F. Staack and Hans H. Maurer

"This paper reviews the metabolism of new designer drugs of abuse that have
emerged on the black market during the last years. Para-methoxyamphetamine (PMA), para-methoxymethamphetamine (PMMA) and...

Submitted by ThirdEyeFloond

18-01-2008
101.18 Kbytes Hits 77
Keywords: meopp mbdp tfmpp pmma mcpp designer-drugs pma metabolism bzp 4-mta mphp mdppp m0ppp ppp

Metabolism of the new designer drug α-pyrrolidinopropiophenone (PPP) and the toxicological detection of PPP and 4′-methyl-α-pyrrolidinopropiophenone (MPPP) studied in rat urine using gas chromatography-mass spectrometry

Dietmar Springera, Giselher Fritschib and Hans H. Maurer,

R,S-α-pyrrolidinopropiophenone (PPP) is a new designer drug with assumed amphetamine-like effects which has appeared on the illicit drug market. The aim of this study was to identify the PPP metabolites using solid-phase extraction,...

Submitted by Gradient

28-07-2009
819.59 Kbytes Hits 9

Metabolism of the recently encountered designer drug, methylone, in humans and rats (2006)

Xenobiotica 2006 Aug;36(8):709-23

Kamata HT, Shima N, Zaitsu K, Kamata T, Miki A, Nishikawa M, Katagi M, Tsuchihashi H.

The urinary metabolites of methylone in humans and rats were investigated by analysing urine specimens from its abuser and after administrating to rats with gas...

Submitted by Heretic.Ape.

08-08-2007
415.75 Kbytes Hits 159
Keywords: metabolism methylone

Methcathinone is a substrate for the serotonin uptake transporter (2003)

Pharmacology and Toxicology 2003 Nov;93(5):219-25

Cozzi NV, Foley KF

We previously reported that the psychostimulant drug methcathinone inhibits serotonin accumulation via the plasma membrane serotonin uptake transporter. By analogy to known substrates for the serotonin transporter, we...

Submitted by Jatelka

11-07-2009
101.17 Kbytes Hits 11

Methcathinone: A new and potent amphetamine-like agent (1987)

Pharmacology, Biochemistry, and Behavior 1987 Mar;26(3):547-51

Glennon RA, Yousif M, Naiman N, Kalix P.

The purpose of the present investigation was to examine the effect of N-monomethylation of phenylisopropylamine derivatives on amphetamine-like activity. In tests of stimulus...

Submitted by chrisn

22-11-2007
472.67 Kbytes Hits 69
Keywords: research-chemicals methcathinone

Methcathinone: A new postindustrial drug (2005)

Forensic Science International 2005 Oct 4;153(1):99-101

Belhadj-Tahar H, Sadeg N.

Methcathinone, a methyl derivative of cathinone, is an illicit drug also known as ephedrone. It is a stimulant found in the "khat" plant, Catha edulis, which can easily be synthesized from pseudoephedrine. Its...

Submitted by ThirdEyeFloond

14-01-2008
84.43 Kbytes Hits 81
Keywords: methcathinone

Methylone and mCPP, Two New Drugs of Abuse? (2005)

Addiction Biology 2005 Dec;10(4):321-3

Bossong MG, Van Dijk JP, Niesink RJ.

Recently, two new ecstasy-like substances, methylone and mCPP, were found in street drugs in the Netherlands by the Drugs Information and Monitoring System (DIMS). Methylone (3,4-methylenedioxymethcathinone) is the...

Submitted by Jatelka

23-11-2007
60.78 Kbytes Hits 87
Keywords: mcpp methylone

Page 1 of 2

Category

Forum Jump

Sitelinks:	Site Functions:
Homepage Wiki Documents Image Gallery Audio Video Forum Blog Groups News	Site Rules Frequently Asked Questions Register to Participate Did you forget your password? All Threads

All times are GMT +1. The time now is 17:28.