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Tramadol Documents

Documents about Dolol, Mandolgin, Nobligan, Tradolan, Ultram, Tramal, Ultracet (trans-(+/-)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl) cyclohexanol))

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Angioedema induced by tramadol—a potentially life-threatening condition (2005)

Left click: open entry/Right click: save entry

Eur J Clin Pharmacol (2005) 60: 901–903

Par Hallberg Gunilla Brenning

Case Report

Discussion Thread

Submitted by Jatelka

23-02-2008
154.42 Kbytes Hits 82
Keywords: tramadol adverse-effects

Assessment of Tramadol

World Health Organisation.

Looks at Chemistry, Pharmacology, Toxicology, Pharmacokinetics, Dependence/Abuse Potential and Epidemiology

Submitted by Jatelka

17-09-2007
305.38 Kbytes Hits 194
Keywords: tramadol toxicology pharmacology pharmacokinetics epidemiology dependence chemistry

Case Report: Fatal overdose of tramadol and alprazolam

A 30-year-old woman, with history of depression, was found dead after the ingestion of an unknown quantity of Xanax (alprazolam), Tramal (tramadol) and alcohol.

Submitted by Bajeda

30-03-2007
53.71 Kbytes Hits 243
Keywords: tramadol alprazolam

Case Report: Fatality due to ingestion of tramadol alone

A rare case of a fatal intoxication in an adult with tramadol alone is reported. In the peripheral blood, tramadol was measured in a concentration of 9.6 mg/l exceeded at least 30-times the normal therapeutic range of 0.1±0.3 mg/l. The concentration of tramadol in liver and kidney, in relation to...

Submitted by Bajeda

30-03-2007
64.04 Kbytes Hits 78
Keywords: overdose tramadol

Clinical Pharmacology of Tramadol

1. Pharmacokinetic Properties
2. Pharmacodynamic Properties
3. Therapeutic Efficacy in Acute Pain
4. Therapeutic Efficacy in Chronic Pain
5. Tolerability
6. Conclusions

Forty-Five Pages of Material

Submitted by Bajeda

30-03-2007
413.42 Kbytes Hits 156
Keywords: pharmacokinetics pharmacology tramadol

Differential role of 5-HT1A and 5-HT1B receptors on the antinociceptive and antidepressant effect of tramadol in mice (2006)

Psychopharmacology (2006) 188:111–118

Esther Berrocoso, M. Olga Rojas-Corrales
Juan A. Mico

RATIONALE: Tramadol, (1RS,2RS)-2-[(dimethylamine)-methyl]-1-(3-methoxyphenyl)-cyclohexanol hydrochloride, is an atypical analgesic which binds weakly to ì-opioid receptors and enhances the...

Submitted by Jatelka

23-02-2008
191.28 Kbytes Hits 14
Keywords: 5ht-1a serotonin tramadol 5ht-1b

Effects of Tramadol on shivering post spinal anesthesia in elective cesarean section

Fatemeh Javaherforoosh1, Reza Akhondzadeh2, Kaveh Beh Aein3, Alireza Olapour4, Mehrdad Samimi5

Abstract: Background and Objective: Post operative shivering is a complication commonly observed in post spinal anesthesia. For prevention and treatment of this complication different drugs are used....

Submitted by Gradient

07-08-2009
176.80 Kbytes Hits 7

Fatal overdoses of tramadol: is benzodiazepine a risk factor of lethality?

Tramadol is a centrally acting analgesic agent used in the treatment of mild to moderate pain. It has a low affinity to opioid receptors and inhibits the reuptake of norepinephrin and serotonin producing an analgesic action by blocking nociceptive impulses in the spine. Although 21 drug-combined...

Submitted by Bajeda

30-03-2007
90.83 Kbytes Hits 157
Keywords: p450 intoxication tramadol benzodiazepines cytochrome

Fatal unintentional intoxications with tramadol during 1995–2005

This study examined fatal unintentional tramadol intoxications among Swedish forensic autopsy cases between 1995 and 2005. All fatal intoxications were selected, in which toxic concentrations of tramadol (>1 mg/g femoral blood) had been detected, and where the forensic pathologist considered the...

Submitted by Bajeda

30-03-2007
124.71 Kbytes Hits 145
Keywords: intoxication tramadol

Hear my song: Auditory hallucinations with tramadol hydrochloride (2000)

British Medical Journal; Dec 23-Dec 30, 2000; 321, 7276

Paul W Keeley; Gillian Foster; Lesley Whitelaw

Case Report

Discussion Thread

Submitted by Jatelka

23-02-2008
149.78 Kbytes Hits 56
Keywords: hallucinations tramadol

Identification of Cytochrome P450 Isoforms Responsible for cis-Tramadol Metabolism in Human Liver Microsomes (Subrahmanayam et al, 2001)

Originally published in JPET

Identifies the enzymes responsible for metabolising Tramadol

Submitted by Jatelka

28-08-2007
174.45 Kbytes Hits 22
Keywords: metabolism tramadol cytochrome

Modest opioid withdrawal suppression efficacy of oral tramadol in humans

Rationale Tramadol is in an unscheduled atypical analgesic with low rates of diversion and abuse and mixed pharmacologic actions, including modest opioid agonist activity.
Objectives The purpose of the current study was to characterize the opioid withdrawal suppression efficacy of oral tramadol....

See also Opiate Addiction Documents

Submitted by Gradient

12-04-2009
626.99 Kbytes Hits 19

Pharmacokinetic-Pharmacodynamic Modeling of the Antinociceptive Effects of Main Active Metabolites of Tramadol, (+)-O-Desmethyltramadol and (-)-O-Desmethyltramadol in Rats (Valle et al, 2000)

Originally published in JPET

Looks at the pharmacokinetics and pharmacodynamics of Tramadol's major metabolites

Submitted by Jatelka

28-08-2007
136.31 Kbytes Hits 23
Keywords: metabolism pharmacokinetics tramadol cytochrome

Physical dependence on Ultram (tramadol hydrochloride): both opioid-like and atypical withdrawal symptoms occur

In the course of the surveillance project, the ISC received reports of withdrawal following abrupt discontinuation of Ultram and in some instances, following dose reductions. In most cases, the withdrawal symptoms consisted of classical opioid withdrawal, but in some cases were accompanied by...

Submitted by Bajeda

30-03-2007
143.04 Kbytes Hits 76
Keywords: addiction tramadol dependence withdrawal opiates

Profiling the subjective, psychomotor, and physiological effects of tramadol in recreational drug users

Study profiles the subjective, psychomotor, and
physiological effects of Tramadol in recreational drug users.

Submitted by Bajeda

30-03-2007
119.86 Kbytes Hits 89
Keywords: drug-use tramadol

Safety and Efficacy of Tramadol in the Treatment of Premature Ejaculation: A Double-blind, Placebo-Controlled, Fixed-Dose, Randomized Study

Tramadol seems to provide significantly better results in terms of intravaginal ejaculatory latency time and intercourse satisfaction versus placebo. Further studies are required to draw final conclusions on the efficacy of this drug in premature ejaculation.

Submitted by Bajeda

30-03-2007
131.60 Kbytes Hits 68
Keywords: tramadol

Serotonin syndrome with tramadol and dextromethorphan

Kung SW, Ng MH. Hong Kong Journal of Emergency Medicine 2007 Jan;14(1):48-52.

Serotonin syndrome is an iatrogenic drug-induced synaptic serotonin concentration related toxidrome.
A 29-year-old man developed agitation, tachycardia and myoclonus of limbs after an intramuscular injection
of 100...

See also Pharmacology Documents

Submitted by Paracelsus

03-06-2007
126.25 Kbytes Hits 107
Keywords: dxm

The effects of tramadol on static and dynamic pupillometry in healthy subjects--the relationship between pharmacodynamics, pharmacokinetics and CYP2D6 metaboliser status (2004)

Eur J Clin Pharmacol. 2005 Jun;61(4):257-66

Fliegert F, Kurth B, Göhler K.

OBJECTIVES: The main objective of the present study was to provide information on whether static and dynamic pupillometry can be used for pharmacodynamic profiling, particularly when investigating opioid-like drugs,...

Submitted by Jatelka

09-02-2008
274.54 Kbytes Hits 10
Keywords: pharmacokinetics tramadol cytochrome

Tramadol Addiction

Letter to the Editor - The Journal of Family Practice

Submitted by Bajeda

30-03-2007
339.23 Kbytes Hits 77
Keywords: tramadol dependence addiction

Tramadol overdose and serotonin syndrome manifesting as acute right heart dysfunction

Garrett, 2004

Submitted by Heretic.Ape.

05-06-2007
245.10 Kbytes Hits 43
Keywords: serotonin-syndrome tramadol

Ultram - Prescribing Information

From Ortho-McNeil - Prescribing information for Ultram in the US.

*Quite a bit of useful information in an array of areas*

Submitted by Bajeda

30-03-2007
78.85 Kbytes Hits 59
Keywords: tramadol

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