Oxymetazoline HCL

[Nicaine]

Contained in 12-hour OTC nasal sprays like Afrin. Apparently it's a selective alpha-2 adrenoceptor agonist -- i.e. a stimulant. Chemical name:

2-[3-hydroxy-2,6-dimethyl-4-t-butylbenzyl]-2-imidazoline

Would be interested in evaporating some the aforementioned nasal spray and snorting a line of it, to see what it does. Anyone gets to it first before me, post your results.

Edit -- the aforementioned nasal sprays appear to contain a very small quantity of oxymetazoline, and largely other gooey crap when evaporated. Experiment may not work.Edited by: Nicaine

[Turricaine]

absolutely no high at all. works wonders for true nasal congestion. can develop physical symptoms if too much is taken such as difficulty in getting to sleep among other things.

[Softrat]

One interesting thing about those nasal sprays is that if you use them too much a very strange form of physical "addiction" can happen.


With some people if they use them night after night the drug will actually cause nasal congestion after it's intial anti congestion effects wears off. To break this "addiction" you have to put up with a really stuff nose for a couple days or take some other type of decongestant.


This effect is mentioned on the side of the box.

[Aopocetx]

Yes, I though the exact same thing when I heard about oxymetazoline. Instead of snorting it, how about just swallowing it?

[IHrtHalucingens]

Why not just spray a bunch up your nose? I mean the oxymetazoline is there and water soluble so it should be absorbed through the mucus membrane and through the BBB. Why drink a most likely nasty substance or reduce it to powder form just to snort it when its sold in a state that is meant for the nose and is most likely alot easier on the nose than the pure powder.

[antigenesis]

Yeah, I just used some for a stuffy nose (worked like a charm). I noticed a slight head change and was like, "WTF?" so I checked the active ingredient and googled it. My beloved forums were right up by the top. :D

Anyway, its too late for an experiment now... At a better time I will check the inactive ingredients for anything possibly dangerous in high doses and SWIM will try it out.

The bottle says 2-3 sprays (not very measured sprays at that) in each nostril, and concentration is at 0.05%. Does anybody have any idea for a dose?

I know one person said no high, but I also know drugs are different for everyone. I noticed a slight but racy little something before the thought of abuse even occured to SWIM, so its sure worth a shot.

[Stephenwolf]

I've also been curious on this. One day out of boredom i had read the banned chem list for the olympics, and Oxymetazoline was one of them. I'd love to hear if anyone tries it... I want to but have no idea about how to go about getting recreational levels... nor do i know how much would be required for a rec. dose.

[Swimster]

ok, this thread is relatively old, but since it was replied to, i will post this quote:

"
...
This drug, not unlike most sympathomimetic amines, has adrenaline-releasing properties due to its mode of action. However, since the application is topical, it has practically no CNS stimulation as of the systemic application of decongestants such as pseudoephedrine...
"

:from WikiPedia

sorry if it dissapointed anyone but.....:(

[Stephenwolf]

That actually says No CNS stimulation because of topical applications. which means only applied to where needed... if taken by any other method as it is adrenaline releasing it would cause stimulative effects..

[sarbanes]

Addiction to Afrin is characterised by rebound tolerance of the worst sort. Orally, can cause the worst form of diaherrea possible.

[sarbanes]

or is it Visine (type) which gives you the runs (orally)?

[HighParadise]

1/3rd of the bottle didn't do anything. I don't know if I should try the rest.

[Zaprenz]

"If accidentally ingested, standard methods to remove unabsorbed drugs should be considered. There is no specific antidote for oxymetazoline. In children, oxymetazoline may produce profound central nervous system depression."

If its an alpha-2 adrenergic agonist it may produce effects similar to clonidine, I.e an anti-hypertensive agent. Alpha-2 adrenergic receptors are associated with a negative feedback loop and stimulating them can reduce the production of catecholamines.

Ok clonidine may have alternative uses, buts clonidine is reliable and tested for oral consumption. SWIM doubts it has any kind of useful effects OTHER than its very effective nasal decongesting properties. :thumbsdown:

Why risk taking high doses of oxymetazoline (untested at those doses) when any effects are going to be similar to clonidine but with more unknown properties or side effects. [?]

http://en.wikipedia.org/wiki/Clonidine