Olanzapine, Alcohol and Cannabis: Safe?

[pinokio]

Hello people,

SWIM (Somene who isn't me at all) is going to have a party with some alc. and prolly also some pot included. He has a question if there are any possible dangers about combining alc or/and weed with let's say 5 - 10mg of Olanzapine (Zyprexa)?

From what he has read, the combo with weed is very plesaurable and potentiate the weed much, yet he has no idea about the alcohol and it's possible dangers.

SWIM is very aware, that antipsychotics are not toys, and should not be used recreationaly, yet he is still interested and would like to see the answer.

Thanks.

pinokio added 56 Minutes and 36 Seconds later...

Also, SWiM'd like to know is it save to insufflate the Olanzapine?

[RaverHippie]

I did some quick research and this note came up interestingly "Olanzapine displays linear kinetics. Its elimination half-life ranges from 21 to 54 hours. Steady state plasma concentrations are achieved in about a week. Olanzapine undergoes extensive first pass metabolism and bioavailability is not affected by food."

if SWIY has any history with olanzapine but only orally, if he attempted to insuflate it, then the drug would hit monumentally harder in comparison. Sublingual ingestion would do the same trick albeit in a less painful manner. Take that as a warning if any attempt is made. I have no experience with this personally and only now learned about it by doing the search for you, so take my advice as you will.

EDIT: Forgot to mention there was a warning that cigarette smoking amplifies the effect of this drug so pot may or may not follow the same pattern.

[pinokio]

Thank you for your feedback.


SWiM has also done a _lot_ of research and more or less has found the same infos.

SWiM is thankful for the answer and looking forward for more, hopefully also from someone with some personal experience.

[Beeblbrox]

My cat wishes to inform SWIM that since he knows a long term Olanzapine user that occasionally takes cannabis and regularly uses alcohol his views might be of some use to him.

For the user that my cat knows the combination of the two/three is not particularly enhancing, and views olanzapine as actually detrimental to the experience of alcohol or cannabis since long term olanzapine has induced (he believes) a more or less semi-permanent deadening/lethargy effect overall in the first place. Hence the 'relaxation' effects (mental and physical) that were previously enjoyed are vastly reduced. However my cats friend apparently still enjoys these other two anyway, possibly out of perverse stubborness.

My cat wishes also to point out that the reports he hears from his friend must be taken with a pinch of salt as the exposure to Olanzapine has been for such a duration he is very unsure as to what life is like without it.

Dangers - physiologically, as yet, none reported. But you really never can tell can you.

If this has been of any use to you a few tins of tuna are much appreciated :-)