Jatelka
03-05-2008, 13:21
A new entry has been added to Drugs Archive
Description:
British Journal of Pharmacology 1983;16 Suppl 2:279S-283S
Bechtel WD (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Bechtel%20WD%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus).
Pharmacokinetic studies were performed in healthy young volunteers and in elderly patients after oral administration of single doses (0.5 mg), increasing doses (0.5-1.5 mg), and multiple doses (1.0 mg) of brotizolam. Brotizolam was absorbed quickly from the gastro-intestinal tract. Elimination half-lives were in the range of 3.6-7.9 h. In healthy young volunteers as well as in elderly patients, there was neither a tendency for brotizolam to accumulate nor was there any indication of enzyme induction. Brotizolam was metabolized almost completely into hydroxylated compounds which were conjugated prior to renal excretion. After oral administration of [14C]-brotizolam, two-thirds of excretion of radioactivity was renal and was completed within 4 days.
To check it out, rate it or add comments, visit Pharmacokinetics and metabolism of brotizolam in humans (1983) (http://www.drugs-forum.com/forum/local_links.php?linkid=4986&catid=129)
The comments you make there will appear in the posts below.
Description:
British Journal of Pharmacology 1983;16 Suppl 2:279S-283S
Bechtel WD (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Bechtel%20WD%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus).
Pharmacokinetic studies were performed in healthy young volunteers and in elderly patients after oral administration of single doses (0.5 mg), increasing doses (0.5-1.5 mg), and multiple doses (1.0 mg) of brotizolam. Brotizolam was absorbed quickly from the gastro-intestinal tract. Elimination half-lives were in the range of 3.6-7.9 h. In healthy young volunteers as well as in elderly patients, there was neither a tendency for brotizolam to accumulate nor was there any indication of enzyme induction. Brotizolam was metabolized almost completely into hydroxylated compounds which were conjugated prior to renal excretion. After oral administration of [14C]-brotizolam, two-thirds of excretion of radioactivity was renal and was completed within 4 days.
To check it out, rate it or add comments, visit Pharmacokinetics and metabolism of brotizolam in humans (1983) (http://www.drugs-forum.com/forum/local_links.php?linkid=4986&catid=129)
The comments you make there will appear in the posts below.