Metabolic basis for the supra-additive effect of the ethanol-diazepam combination in mice (1977)

[Jatelka]

A new entry has been added to Drugs Archive

Description:
British Journal of Pharmacology 1977 May;60(1):83-90

Paul CJ (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Paul%20CJ%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Whitehouse LW (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Whitehouse%20LW%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus)

Ever wondered about the pharmacology of the alcohol/benzodiazepine interaction? Well here you go!

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[Politicalchalk]

Interesting! Swim always thought there was some mythical chemical reaction between ethanol and diazepam that seemed particularly alluring, as opposed to either alone (ie: in testing). Almost reminds me of when cocaine and alcohol is combined, cocaethynol is created and more dangerous that then either two combined. Chloral Hydrate and Alcohol (A "Mickey") make Chloral Alcholate, which can surpress breathing. Alcohol does seem to make a lot of unique chemical cousins!