Jatelka
02-03-2008, 10:17
A new entry has been added to Drugs Archive
Description:
J Psychopharmacol. (javascript:AL_get(this, 'jour', 'J Psychopharmacol.');) 1997;11(3):233-9.
Gorissen M (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Gorissen%20M%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstractPlusDrugs1), Tielemans M (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Tielemans%20M%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstractPlusDrugs1), Coenen A (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Coenen%20A%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstractPlusDrugs1).
Benzodiazepines (BZDs) give rise to memory impairments. It has been questioned whether or not these impairments are related to the drug's sedative, alertness-reducing effects. Therefore, in this study, alertness was reduced in healthy subjects both pharmacologically (15 mg diazepam) and non-pharmacologically (24-h sleep deprivation, SD) in order to assess whether these manipulations both gave rise to memory impairments. Twelve subjects were tested using a repeated measures cross-over design. Drug administration was placebo-controlled and double-blind. A subjective alertness reduction was established after diazepam intake and even more after SD. Additionally, performance-disruptive effects were found on psychomotor tasks after both SD and liazepam intake. However, only diazepam, and not SD, impaired delayed recall of a word list and recall of paired associates. Thus a reduction in alertness, i.e. sedation, cannot fully account for BZD-induced memory impairments.
To check it out, rate it or add comments, visit Alertness and memory after sleep deprivation and diazepam intake (1997) (http://www.drugs-forum.com/forum/local_links.php?linkid=4646&catid=129)
The comments you make there will appear in the posts below.
Description:
J Psychopharmacol. (javascript:AL_get(this, 'jour', 'J Psychopharmacol.');) 1997;11(3):233-9.
Gorissen M (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Gorissen%20M%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstractPlusDrugs1), Tielemans M (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Tielemans%20M%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstractPlusDrugs1), Coenen A (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Coenen%20A%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstractPlusDrugs1).
Benzodiazepines (BZDs) give rise to memory impairments. It has been questioned whether or not these impairments are related to the drug's sedative, alertness-reducing effects. Therefore, in this study, alertness was reduced in healthy subjects both pharmacologically (15 mg diazepam) and non-pharmacologically (24-h sleep deprivation, SD) in order to assess whether these manipulations both gave rise to memory impairments. Twelve subjects were tested using a repeated measures cross-over design. Drug administration was placebo-controlled and double-blind. A subjective alertness reduction was established after diazepam intake and even more after SD. Additionally, performance-disruptive effects were found on psychomotor tasks after both SD and liazepam intake. However, only diazepam, and not SD, impaired delayed recall of a word list and recall of paired associates. Thus a reduction in alertness, i.e. sedation, cannot fully account for BZD-induced memory impairments.
To check it out, rate it or add comments, visit Alertness and memory after sleep deprivation and diazepam intake (1997) (http://www.drugs-forum.com/forum/local_links.php?linkid=4646&catid=129)
The comments you make there will appear in the posts below.