[From Erowid (http://www.erowid.org):]
<CENTER>Interactions Between MAOIs, SSRIs, and Recreational Drugs
by Erowid</CENTER>
<LI>Avoid mixing MAOIs and SSRIs.
This can lead to serotonin syndrome and can be dangerous.
<LI>Do not mix MAOIs with Stimulants (including MDMA).
This can lead to hypertensive crisis and can be deadly.
<LI>SSRIs in Combination with MDMA
Generally reduces the effects of the MDMA significantly.
<LI>SSRIs in Combination with Psychedelics
Generally reduce the effects of the psychedelic a bit.
<LI>MAOIs in Combination with Psychedelics
Generally increase the effects of the psychedelic significantly. Be extremely careful.</LI>
SSRIs
Strong SSRIs are significantly more common than MAOIs. Many commonly prescribed pharmaceutical anti-depressants are SSRIs, including Prozac (Fluoxetine), Paxil (Paroxetine), Zoloft (Sertraline), Celexa (Citalopram), and Desyrel (Trazodone).
MAOIs
Strong MAOIs are less common, but include prescription anti-depressants like phenelzine (Nardil), tranylcypromine (Parnate), isocarboxazid (Marplan), l-deprenyl (Eldepryl), moclobemide (Aurorex or Manerix), furazolidone, and pargyline. Ayahuasca also contains MAOIs, generally in the form of Banisteriopsis caapi or Syrian rue (harmine and harmaline).
[Original Here (http://www.erowid.org/chemicals/maois/maois_info8.shtml)]
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<CENTER>Drugs to Avoid with MAOIs </CENTER>
<CENTER></CENTER>
<CENTER>It's not totally understood how various MAOIs interact with the body. Some are more likely to have negative interactions with foods and drugs than others. To be as safe as possible, avoid the following drugs while you are taking an MAOI antidepressant and for two weeks after stopping it. </CENTER>
<UL>
<LI>All SSRIs (prozac, zoloft, and several other anti-depressants)
SSRIs block the reuptake of serotonin in the brain. Because MAOIs inhibit the breakdown of serotonin, the combination of MAOIs and SSRIs can lead to dangerously high levels of serotonin in the brain (serotonin syndrome). Symptoms of serotonin syndrome include nausea, vomiting, blackouts, memory loss, increased blood pressure and increased heart rate.
<LI>Demerol
<LI>Cold preparations (tablets, capsules, or liquids such as Comtrex)
<LI>Cough medications containing decongestants, Dextromethorphan (DXM)<SUP>1</SUP> (http://www.erowid.org/chemicals/dxm/faq/dxm_general_info.shtml#toc.4.16.1), or Demerol
<LI>Sinus medications
<LI>Nose drops or nasal sprays
<LI>Nasal decongestants
<LI>Hay fever medications
<LI>Diet pills
<LI>Amphetamines --- speed
<LI>MDMA --- Ecstasy
<LI>MDE, MDA, and other "MD" compounds
<LI>Cocaine --- crack </LI>[/list]
MAOIs can and will dramatically increase the effects of some of these drugs to the point of becoming dangerous. Other plants and chemicals are intentionally combined with some reversible MAOIs (plants such as Syrian Rue or Banisteriopsis Caapi, or their primary active chemicals the harmala alkaloids) to intentionally increase the effects of chemicals such as DMT (as is done in many forms of the ayahuasca brew) or sometimes phenethylamines such as Mescaline or 2-CB. All of these "potentiating" combinations can be dangerous if used improperly.
[Original Here (http://www.erowid.org/chemicals/maois/maois_info3.shtml)]