View Full Version : liquid oral suspension MS.. injectable?
KingBenzo1208
12-01-2005, 00:46
I have liquid cherry flavored MS. can i add water cook and inject this??
20mg cc, over 5000mg in this bottle. tastes like ass and makes me puke. Im not a newbie to the injection scene but im unsure of whats in this stuff. there is no content label.
I had Morphine Sulphate in an oral syrup which also tasted rough. I have tried injecting it, I cooked it in a spoon to try and help sterilise it and reduce the volume of liquid by evaporating off the water. However the solution is thick and is difficult to draw through cotton to filter. It did not feel good injecting it and felt like the vein was clogging!!! It did have some of the desired effect but I did not enjoy this way of using it and whilst I don't know what is in the solution I think it is risky.
It is much easier to stick with MS Contin tabs and prepare these for injection. Personally I will not be injecting the syrup again.
KingBenzo1208
13-01-2005, 00:13
see i was wondering if added h20 mixed it to bind to the MS. then
heated it. If not only would it draw easier but i might get the same
desired effect.
anyone else tried this?
i got a hell of alot of it and the oral metod is just unacceptable
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Micklemouse
13-01-2005, 00:27
And so are blood clots and clogged veins. Look into extracting the morphine and then shooting it. I very much doubt that diluting it alone will be safe enough. Please don't be a statistic.
KingBenzo1208
13-01-2005, 15:50
so the next question is how can i extract the MS from the liquid
syrup? blood clots and clogged viens dont sound like too much fun.
thanks!<!--
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i would be careful because of binders and other stuff in pills.
But in general, if you are careful, it can be effective. Check this link youll find a good way to inject pills:
http://www.heroinhelper.com/curious/chemistry/injecting_pill (http://www.heroinhelper.com/curious/chemistry/injecting_pills.shtml) s.shtml
Micklemouse
18-01-2005, 02:51
Kingbezo's asking about liquid suspension, not pills... http://www.drugs-forum.com/forum/smileys/smiley4.gif
KingBenzo1208
18-01-2005, 08:43
Yup, liquid not pills, ive been injecting pills for some time now. thanks though. http://www.drugs-forum.com/forum/smileys/smiley2.gif
It has been a week, and no one seems to know how to inject the suspension. so im just going to slam it and see what happens. http://www.drugs-forum.com/forum/smileys/smiley5.gif
I plan to add Sodium chloride 9% and heat it just to a boil. It is
pretty thin consistancy so i imagine it should dilute pretty well. no
sense in really filtering it but i will draw it through a filtered
needle i suppose.http://www.drugs-forum.com/forum/smileys/smiley32.gif
I will update this post if i dont http://www.drugs-forum.com/forum/smileys/smiley11.gif
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Yeah youll find more missunderstandings in my postings due to my english...
KingBenzo1208
19-01-2005, 17:06
everything seems cool. good high. good times a little swelling near the injection site. <!--
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KingBenzo1208
23-01-2005, 02:45
Follow Up: Well after about 3x doing this. diluting with NS
heating and shooting, My arm vien is begining to feel a lil
clogged.
So the point to maintain is um well.....dont do this.
ah well some people learn by personal history some
people can learn vicariously. I happen to need personal history.
should have headed spyders reply. but a am a young man and
Know a "better Way" to alter the same damn process.
It of course didnt work and now i will die of some embolism that breaks off of my radial vien. So i life.....
GoodBye Cruel Cruel World..........
http://www.drugs-forum.com/forum/smileys/smiley11.gif
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You could try the following to get out the morphine sulfate out of Oramorph while leaving the other useless stuff behind.
stearic acid is soluble in chloroform, ether, toluene, and other such exotic non-polar type solvents. Commercial stearic acid USP is what they use (which is a bit more than just stearic, but...). these forms are also soluble in the above, but they are actually a bit more soluble in choloroform . However, Oramorph, like MSContin, also contains silicon dioxide, hydroxypropyl methylcellulose and lactose. But one can deal with it, the exception being the lactose, but, that doesn't seem like a big deal.
So: stearic USP is solubleinCHCl3, methylcellulose is soluble in cold water, but not in hot water (it precipitates out) and SiO2 is soluble in niether. So, if we were to use a CHCl3/Aqueous biphasic solution for extraction, that SiO2 should just fall out and sink into the chloroform and thus present no problem.
Why would it not be possible to take apart this matrix with a biphasic CHCl3/dH2O mixture, extract the MS off into the aqueous layer, while the stearic and other waxes/parrafins would also get dissvoled in the CHCl3. MS is insoluble in CHCl3, but very soluble in dH2O, expecially in slightly acidic dH2O. The SiO2 just sinks to the bottom, We could separate the aqueous phase, heat it up to 70-80C to both eliminate any traces of chloroform and also to precip out the methylcellulose.
Here we go:
1) 2 Oramorph 30s were placed in a solution of 20ml of CHCl3 in a 75ml erlenmeyer and put on a magnetic stirrer. The stirrer was turned on, and allowed to run.
- Within a mere 2-3 minutes, the oramorphs had totally dissolved in the chloroform, but there was a cloudy white substance still visible in the solution.
- 20 ml of dH2O were measured out, and to this was added 0.4 g of citric acid. This produced a pH of 6.2.
- The H2O / citric solution was added to the CHCl3 solution, and was shaken vigorously for several minutes.
- The result was that ther was a clear layer of water on top, but a nasty emulsion layer had formed at the CHCl3 / H2O interface, when 15 more ml of dH2O was added, the mixture was shaken once again, and this broke the emulsion, which was now a suspension floating in the CHCl3 layer.
- The water layer was carefully decanted off. The smell of CHCl3 was detectable in the now decanted water layer, and this was put on the steam bath and a thermometer was clamped over wit the bulb in the aqueous soution. The temperature was allowed to hit 75C for about 15 minutes. a very small qty of white precipitate appeared. This was then filtered while still hot.
- The result was a very clear solution with some bubblies on top. The solution was once again filtered and there was no more CHCl3 aroma detectable from it.
However, this aqueous layer had a sweet taste to it, which is reminiscent of small traces of CHCl3, or perhaps this was the lactose, or a fraction of cellulose that had reacted with the citric acid.
A small sample was removed from this aqueous soution using an eyedropper, which was dropped into 5 ml of the p-dimetylaminobenzaldehyde/H2SO4 reagent (this is an easy to make reagent specifically for the detection of morphine, ethyl-M, codeine and diacetyl-M, and does not respond to trace amounts, or does so with only a light red color, you can also use formalin solution and sulfuric, but unless you use super good grades of formalin and H2SO4, m, yet get a notso sensitive reagent, we'll ralk about this in identification tests ). Upon the very first drop, the reagent immediately turned a deep red, which is a positive result for M.
As a precation, the aqueous solution was put back on the steam batch for 10 more minutes, but this still did not eliminate the sweet taste. (However, there was no smell of chloroform at all, cold or hot).
After reviewing some literature, it was determined that these small trace amounts of chloroform are not all that harmful anyway, so, an Oramorph experienced subject drank the 25 ml of the 30 ml of aqueous solution. (5 ml of solution are to be saved to be analyzed at one of our workplaces within the next couple of days, we are both very curious and need to know what all is in there. CHCl3 will be easy to detect, a regular visible light spectrometer can detect CHCl3.).
Within 15 minutes the subject described the familiar sensations of the effects of opiates, but, she reported that the onset of the effects were very quick compared to Oramorph.
The CHCl3 and other junk solution was washed again with some cold water, that water was separated and a few drops were put into some of the 5 ml of the p-dimetylaminobenzaldehyde/H2SO4 reagent . The result was negative, no red or pink color at all.
OK, so it looks like we have a largely successful extraction from the Oramorph. I am concerned about the sweet taste that was in the aqueous layer, because it might be some residual CHCl3 or may simply be the lactose or a reaction product with the lactose/cellulose/citric acid.
The extraction looks to have been 100% efficient, as little or no morphine sulfate was left behind in the CHCl3.<BR style="mso-special-character: line-break"><BR style="mso-special-character: line-break"><?:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />
Fantasian
03-05-2006, 07:00
hell of alot of work rather than just ignoring the taste :D
teddybearpicnics
12-08-2007, 02:03
swic mixed about 20 units of water with his cherry blah and it worked fine, a bit of swelling thats it. no clogging that i know of ;/
hell of alot of work rather than just ignoring the taste :D
I think the work is probably worth it. I've drank oramorph a few times and every time it triggered the gag reflex straight away. It took some serious effort to not throw it all back up.