View Full Version : Potentiating morphine
Swim has read on these forums about potentiating opiates through using grapefruit juice and antacids.
Swim would to know is it possible to potentiate Sevredol and MST the same way or any other way??
Forthesevenlakes
08-09-2006, 00:17
sevredol, swim is recalling from swiy's last post, is a morphine preparation. grapefruit juice can potentiate morphine by inhibiting its breakdown in the liver (thus increasing the time that its in the system) and antacids do so by basifying the stomach environment (so more gets absorbed there). the antacid cimetadine (marketed as tagamet) is particularly effective since it both inhibits one of the cytochrome p450 enzymes that break down morphine, and functions as an antacid.
a low dose of dxm can be used to potentiate opiates/opioids. 30-60 mg is generally used, since it gives a potentiation effect without becoming a dxm trip.
quinidine found in tonic water should have a similar effect as the grapefruit juice.
this thread may also have other ideas. (http://www.drugs-forum.com/forum/showthread.php?t=7458) happy potentiating!
also, swim is thinking of making this thread into one big potentiation megathread and trying to merge it with the thread he linked to. so if anyone else has ideas for potentiation of opiates please post them here.
Again swiy has helped out swim, cheers.
I notice that Tagamet is mentioned, swim takes Losec (omeprazole) and wonders whether it could be used as well?
It would be great if we had all the potentiation posts in one thread.
Cheers again.
Forthesevenlakes
08-09-2006, 01:00
omeprazole could be tried, but swim does not think it would work. omeprazole is a proton pump inhibitor, and somehow can help with ulcers that way. it does not seem to be a true antacid.
tagamet works because it an antacid, but it is also unique (to swim's knowledge anyway) in that it inhibits a cytochrome p450 enzyme that would normally metabolize morphine as well. most antacids and other ulcer medications do not do that. thats why swim mentioned tagamet specifically.
however, swim has never tried omeprazole, and maybe it would work, although swim does not see theoretically how it could do so.