Benzodiazepine Equivalent Doses

[Jatelka]

Thought this might be useful.

Contributions to it have also come from darkbreed, kareena, Moda00, and WeareStardust

Brand names for these drugs can be found here...
http://www.drugs-forum.com/forum/showthread.php?t=37196&highlight=brand+names

She appreciates that benzos have different sedative, anxiolytic and myorelaxant properties but this is essentially a tool for converting to diazepam (usually for withdrawal purposes)

Benzodiazepine[/B]"] Benzodiazepine|Half-Life (hours)|Equivalent dose (to 10mg Diazepam)|Indication
Alprazolam|6-12|0.5mg|Anxiety
Bromazepam |10-20|5-6mg|Anxiety
Brotizolam |6-7|0.25mg|Anxiety
Camazepam|6-11|? equivalence|? Indication
Chlordiazepoxide|5-30 (36-200 for active metabolite)|25mg|Anxiety, Alcohol Withdrawal
Cinolazapam|9|40mg|? equivalence
Clobazam|12-60|20mg|Anxiety, Anticonvulsant
Clonazepam|18-50|0.5mg|Anxiety (not in UK), Anticonvulsant
Chlorazepate|36-200 (including active metabolite)|15mg|Anxiety
Clotiazepam|6-7|5-10mg|? indication
Cloxazolam|55-77|1-2mg|? indication
Delorazepam|60-200|? equivalence|? Indication
Diazepam|20-100 (36-200 for active metabolite)|10mg|Anxiety, Anticonvulsant
Doxefazepam|3-4|? equivalence|? Indication
Estazolam|10-24|1-2mg|Hypnotic
Etizolam|3-15|1-2mg|? indication
Fludiazepam|23-48|? equivalence|? Indication
Flunitrazepam|18-36 (36-200 for active metabolite) |1mg|Hypnotic
Flurazepam|40-250 (including active metabolite)|15-30mg|Hypnotic
Halazepam|15-35 (15-100 for active metabolite)|40mg|Anxiety
Haloxazolam|? Half life|5mg|? indication
Ketazolam|30-100 (36-200 including active metabolite)|15-30mg|Anxiety
Loprazolam|6-12|1-2mg|Hypnotic
Lorazepam|10-20|1mg|Anxiety, Anticonvulsant
Lormetazepam|10-12|1-2mg|Hypnotic
Medazepam|36-200|10mg|Anxiety
Mexazolam|70|1mg|? indication
Midazolam|2-6|5mg|Sedation
Nimetazepam|? Half-life|? equivalence|? Indication
Nitrazepam|15-38|10mg|Hypnotic
Nordazepam|36-200|10mg|Anxiety
Oxazepam|4-15|20mg|Anxiety
Oxazolam|10-20 (36-200 for active metabolite)|60mg|? indication
Pinazepam|40-100 (36-200 for active metabolite)|20mg|? indication
Prazepam|36-200 (including active metabolite) |10-20mg|Anxiety
Quazepam|25-100|20mg|Hypnotic
Temazepam|8-22|20mg|Hypnotic
Tofisopam|6-8|100mg|? indication
Triazolam|2|0.5mg|Hypnotic


Non-benzodiazepines with similar effects

Zaleplon (Sonata) 2, 20mg
Zolpidem (Ambien) 2, 20mg
Zopiclone (Zimovane) 5-6, 15mg

Sources: Ashton, pubmed, the lovely folk from df

[Fantasian]

Great info, SWIM is glad to have access to many benzo's and this table helped significantly.

[acexnx316]

If I am not mistaken, you did not include the following Benzodiazepine's (Click on each one for a bit more info):

D03083 Bentazepam (USAN) (http://www.genome.jp/dbget-bin/www_bget?dr+D03083)

D03631 Cyprazepam (USAN) (http://www.genome.jp/dbget-bin/www_bget?dr+D03631)

D01293 Ethyl Loflazepate (JAN); Meilax (TN) (http://www.genome.jp/dbget-bin/www_bget?dr+D01293)

D01286 Flutazolam (JAN); Coreminal (TN) (http://www.genome.jp/dbget-bin/www_bget?dr+D01286)

D01279 Flutoprazepam (JAN); Restas (TN) (http://www.genome.jp/dbget-bin/www_bget?dr+D01279)

Sorry I'm too lazy to report the dosages/mg available in, half-lives, equivalent dosages, etc., but check out http://www.genome.jp/dbget-bin/get_htext?Drug+-f+F+A (1st Level) and/or http://www.genome.jp/dbget-bin/get_htext?Drug+-f+F+E (5th level) for more info (You can also do a text search).
Although all the meds listed on the page are not available in the USA, some are, some can be imported, some are illegal/banned, etc. it is still a great page.

Has information for other types of meds besides benzos as well, such as narcotics, barbituates, etc. too.

Thought you all may appreciate it.

Pz.

[jesusfreak666er]

Swim never really understood these charts, equivalency of dose in reference to what? (IE: sedation, anti- convulsive, what)

[Jatelka]

Equivalence is to diazepam, for the purposes of alleviating withdrawal symptoms when detoxing. Therefore 0.5mg Alprazolam equates roughly to 10mg diazepam, which equates roughly to 20mg Temazepam.

[Psychopatic]

I'm working on a list containing all known benzodiazepines. If anyone have information about the substanses in the list (equivalence, half-life & active metabolites), I would be grateful! The substanses in red, I have no info about, the substanses in orange, I only have the half-life , the green is complete already.

But I have the CAS-number for every substanse, if needful!

Benzodiazepines:
Adinazolam
Alprazolam
Arfendazam
Bentazepam
Bromazepam
Brotizolam
Camazepam
Carburazepam
Chlordiazepoxide
Cinolazepam
Ciprazepam
Climazolam
Clazopam
Clobazam
Clobenzepam
Clonazepam
Clotiazepam
Cloxazolam
Delorazepam
Diazepam
Dibenzepine*
Demoxepam
Doxefazepam
Elfazepam
Estazolam
Ethyl dirazepate
Ethyl carfluzepate
Ethyl loflazepate
Etizolam
Fletazepam
Fludiazepam
Flunitrazepam
Flurazepam
Flutazolam
Flutemazepam
Flutoprazepam
Fosazepam
Gidazepam
Girisopam
Halazepam
Haloxazolam
Homochlorcylizine*
Iclazepam
Ketazolam
Lofendazam
Lopirazepam
Loprazolam
Lorazepam
Lormetazepam
Meclonazepam
Medazepam
Menitrazepam
Metaclazepam
Mexazolam
Midazolam
Motrazepam
Nerizopam
Nevirapine*
Nimetazepam
Nitrazepam
Nordazepam
Nortetrazepam
Oxazepam
Oxazolam
Phenazepam
Pinazepam
Pivoxazepam
Prazepam
Potassium chlorazepate
Potassium nitrazepate
Pranazepide*
Premazepam
Proflazepam
Propizepine*
Quazepam
Ripazepam
Sarmazenil*
Siltenzepine*
Sulazepam
Tarazepide*
Temazepam
Tetrazepam
Tibenzonium iodide*
Tivirapine*
Tofisopam
Tolufazepam
Triazolam
Tuclazepam
Uldazepam
Zapizolam
Zolazepam* Is unsure if this really counts as benzodiazepines

Non benzodiazepines, but with similar effect:
Alpidem
Eszopiclone
Indiplon
Zaleplon
Zolpidem
Zopiclone

[Jatelka]

Welcome Psychopatic: That would indeed be an astonishing resource!

FYI: Nivaripine and Tivirapine are non-nucleoside reverse transcriptase inhibitors used to treat HIV infection (they stop the virus replicating)

Tibenzonium iodide is an anti infective agent used for oral hygiene

Tarazepide is a cholecystekinin A antagonist (pancreatic enzyme antagonist)

Sarmazenil is a benzodiazepine receptor inverse partial agonist. It has effects similar to flumazenil which is used to REVERSE the effects of benzodiazepines

Homochlorcyclizine is an anti-histamine (H1 receptor antagonist) similar to promethezine with some anti-cholinergic and antibradykinin activity

Dibenzepine is (as far as SWIJ can work out) a tricyclic antidepressant

Good luck in SWIY's quest, and please take some time to read the rules and find out a bit more about how df works!

[Psychopatic]

Thank You!

I these substanses came up when I searched, all of the had "-xxx-benzodiazepin-xxx", in their generic names. But like clozapine, which is a medicine to treat schizophrenia, it's even called a dibenzodiazepin.

[~lostgurl~]

Zopiclone (Zimovane) 5-6, 15mg


Zopiclone's brand name is Immovane (typo) also SWIM disagrees with the Ashton Manual on the Zopiclone dose, she says 7.5mg of Zopiclone or less would be equivalent to 0.5mg of Clonazepam, definitely not 15mgs. When SWIM first started taking Zopiclone 3.75mg would knock her out.

[Jatelka]

SWIM disagrees with the Ashton Manual on the Zopiclone dose, she says 7.5mg of Zopiclone or less would be equivalent to 0.5mg of Clonazepam, definitely not 15mgs.

The equivalence is to Diazepam, not Clonazepam. And Zopiclone IS marketed as Zimovane (in the UK anyway)

[pixplzthx]

Just thought I'd add a pretty picture to this thread. I find the following kinds of charts easier to read. I hope it helps:

Chart shows equivalants, onset, peak and half life (http://www.vhpharmsci.com/VHFormulary/Tools/Benzodiazepines-comparison.htm)

Note: Uploaded to archive

[wearestardust]

Further research turns up a more accurate half-life for Rivotril (clonazepam) as between 40 and 150 hours. So it does have a pretty high range and the top end is quite high, which is what I suspected.
Anything with the same figures as diazepam, such as the excellent prazepam (Centraz, Lysanxia 40mg) has the active metabolite nordazepam. I particularly like to use the 15mg nordazepam available in many european countries, especially the excellent NORDAZ, which appears to be on sale in France only now. Calmday is more common, but Nordaz is a higher quality anxiolytic.