View Full Version : Anal use - Benzodiazepines rectally?
IHrtHalucingens
08-02-2006, 20:03
To administer a substance rectally, does it need to be water soluble? SWIM has no knowledge of administering anything this way, honeslty its always kinda weirded him out, but im becoming interested. To him it would make sense that the substance would have to be water soluble, much like snorting it. Is this true? or is SWIM way off? SWIM is interested in taking xanax in this manner if it would make for a better time than sublingually. Any info would be greatly appreciated. Thanks
Pinkavvy
08-02-2006, 20:16
Anything that can be taken sublingually can be taken rectally; it's the same concept and prcoess ... but the lining of the rectum is much more absorbant the lining of the gums. :)
IHrtHalucingens
08-02-2006, 20:26
SWIM wasnt sure if the rectum was more like the mouth of nose. But you cleared that up. SWIM is very interested in this now, he'll prolyl start off with 1-2mg and see from there. So is this much faster acting, since its more obsorbant, or is it just stronger all together? And how would he go about doing this? Is there an optimum depth? SWIM is completely oblivious. Thanks again.
raven3davis
09-02-2006, 03:26
Try it! It will definitely work but SWIM is unsure if it will increase the effects, and if so by how much. Xanax is already potent enough for swim, and cheap enough to not really care about increasing the effects. Now MDMA is a completely different story. A rare experience and definitely worth getting every penny out of your trip.
You should try plugging once just to see what happens and be sure to report the results. Be sure to stick it up to the second nuckle and dont take a dookie for about 30 minutes.
IHrtHalucingens
09-02-2006, 04:50
Of course SWIM could tak few ectra but SWIM wanmted tp try t save it and have as much fun with it as possivle. SWIM did 4mg anally along with another 2 mg orwslly as well as about 550mg dxm,. and smoked some weed called incrredible hulk and took one bonmg hit and was set for the reast of the night. The xnanx was definately more noticable than usual even at a smaeller dosages, i will definatlety use this method again. Swim is fucked up its even hard ot type.
raven3davis
09-02-2006, 05:00
Damn what a combo! SWIM hasnever had incrediclbe hulk weed but thats an interesting name. Seems you might have found a good way to save your xanax. Honestly SWIM would rather stick his finger up his ass than stick a xanax in his mouth. Xanax pills have to be some of the worst tasting pharmecudicals! DAMN!! SWIM doesnt know if it is just the particular brands he has tried, but the 2mg xanax bars taste like crap. SWIM is guessing its mostly the binders and such because 2mg of xanax powder probably wouldnt taste very bad.
IHrtHalucingens
09-02-2006, 06:12
I dont knopw aboput that,. Just cuz i try new things without prejudice doesnt necceralilly make me gay and wanting other things ups there. This is strictly for scientific purposes. But if this the best way to administer its going to happen asd long as it takes for a new better method to apprear.
PS i think i have a little more self respect than to put anyhint more than a pill up there
Pinkavvy
09-02-2006, 07:32
IHrtHalucingens is right. Rectal administration is a effecient way to administer many drugs, and saves on dosage as well ... keeping your tolorance lower and your wallet fuller. It's also a noticably better high, cleaner, faster comup, etc. You should search the wine enema thread in the alcohol forum. :P
Cheers IHrtHalucingens!
Richard_smoker
09-02-2006, 17:46
Yes, once you cross the line, you'll be crushing up all KINDS of pills, measuring out RC's, mixing together with wine and whatever else, then squirting in and out of a 3-6cc syringe (without a needle). Then, once you're ready, you can lube up the squirt end, and carefully administer the tip into your shithole, relax, and FIRE_AWAY!!!!
As said earlier, just DON'T poop it out. Hold it in.
you'll be flying around the room in NO time. Just remember EVERTHING'S stronger! I suggest starting out this anus mania with 1/2 of everything you'd normally do, and please--wait until you're constipated or just don't have to poop for a while. you don't want to lose everything!
I know someone who went off the deep end, wanting to stick ANYTHING he could find up his ass and 'try it out'. He even started telling everyone (including his wife) that he was gay now because he loved it up the ass. (he wasn't gay. gay is when you like to feel another man inside there.)
just thought i'd throw in a word of encouragement as well as some caution. You're gonna want to tell the whole world that you love sticking stuff in your ass. But I probably wouldn't. Just look what that did to SWIM's life.
IHrtHalucingens
09-02-2006, 18:17
HAHA i dunno if im going to be running around telling people i like putting things up my ass. Most people wouldnt understand. here at least people realize the benefits of the procedure. plus its not so much the sticking things up there that i like its the effects that come from the substance that is up there. I used to be very apprehensive about it but once you try it its not as bad as you would think and is quite enjoyable. So from a first time tryer I WOULD recomend it. =)
Herbal Remedy
12-02-2006, 19:39
do you have to crush the pills before insertion or do u just plug them whole?
Richard_smoker
14-02-2006, 09:18
Crush, dissolve in water, squirt in anus. Now squeeze your anal sphincter until you don't feel the need to take off like a water-propelled rocket child's toy.
Obviously if you take a shit, you're going to have to re-squirt the entire contents of your toilet bowl. So remember that when you're fighting the urge to shit. Know that it could be a WHOLE lot worse.
absorbtion will be much faster and thorough.
calmascanbe
15-03-2006, 03:44
Swim broke down and tried clonazepam rectally. The idea of using less was overpowering. I had to try it and had no bang at all , but 3mg. went all day. My second dose wasn't needed. My next experiment will be xanax ,when possible.
calmascanbe
20-03-2006, 19:41
SWIM did it rectally again , but was a waste this time. SWIM took 4mg and nothing. SWIM's advice is to use the system occationally.
kritikal
29-03-2006, 08:29
Rectal is the best procedure.
I dont see why so many people are against it! It is another part of your body for gods sake. You can put something in your mouth where saliva comes from, you can put something in your nose where snot comes from, you can have sex with someone and be using "private parts", you can jab a needle into your arm where blood comes from.
The anus is just a dump truck if you will. The only stigma on this is because ppl see Rectal Administration as being related to being gay. The feeling of something going up there is not quite comfortable but with the relase of fluid one cant even feel it. The feeling can only be compared to going to the toilet.
I dont see how someone can burn there nose from snorting, jab needles in there arms and leave rails etc. But not Administer in what i think is the safest possible method next to Oral.
If you dont want to do it then i guess you are missinng out. People who have the courage to try the method basically agree it is the best. Call them enlightened if you will :)
the idea of a rectal dose of xanex has great potental.the quicker a drug can enter the blood stream the better.plus swim wouldnt have to worry about the binders as swim is positive most asses are chock full of just about anything you can imagine.hell swim would be willing to bet a paycheck that some peeps have stuck whole potatoes and a bottleof grape jelly up there. just go to rotten dot com and you will see the proof.its gross but true.so go ahead stick a tiny pill up there wat can it hurt?fook who knows ya might even like it...............
Swim said i dont know about this stronger in the date(rectum) concept, (but swims experience is limited to coke and coffee in the date). I imagine that the rectum is better with ingested drugs but not snorted. As swim has taken black coffee enemas (it seems to clear the liver! beleive it or not) and it seems to have a nicer buzz, stronger and faster and clearer than drinking coffee according to swim. I think this may take on into a new kind of coffee shop concept (perhaps in Amsterdam first though)
I write this in the Xanax section for swim uses Xanax when swim can to come down of coke,
Swim once had a relative abundance of cheap coke, due to working in Bolivia Swims nose was a bit on the raw side as a result of this abundance swim mixed a quarter of a gram in about 2 small but full syringes worth of water,
then swim took about a quarter of this, so lets say what would of been a strong line about 60 mg swim reported it took longer to come on than snorting and was slightly different in high, more stimulant, a little less euphoria swim thought and weaker than if swim put it in the snoz
Swim thinks the ass route takes your drugs to the liver first via the portal vein
the nose goes srtraight to the brain first, but a physiology student may correct this??
Needless to say swim soon had stacked the quarter gram in the butthole and was feeling good, but if swim snorted all that coke in the same half hour period swim would be feeling it was way too much and reaching for the xanax a lot sooner
Fantasian
04-07-2006, 19:31
SWIF commonly uses Diazepam (valium) rectally in combination with opiates to deal with acute chronic pain, it is very effective and has a very fast onset. SWIF will experiment with all benzodiazapines rectally at some point.
now swim has a 50 cc syringe without the needle and is going to try taking the xanax rectally. now he has 4 pills of .5mg xanax. He plans on taking 2 orally and the other two rectally and the question is how far does he put the syringe up his hole? he does not mean to disgust anyone but is unsure of how far so it doesn't leak out? also how much water should he mix the 2 pills with? 30 cc's?
Well swim decided to do a enima with the xanax. he first took one .5 xanax pill orally and then crushed up two .5mg xanax pills and then mixed with about 80cc of water until it was a paste. Then he got a 50cc syringe without the needle and got 50cc of the paste and injected it his anal cavity (stick the syringe all the way up to the 45-55 cc line). Then he had to do it agian with another 30 cc's to finish the rest off. It was a very quicker onset then orally and he did not think that 1.5mg would do anything to him but it did. He thought he would post this for anyone wondering and give it a thumbs up! Since he has been getting alot of negativity from the forum he figured he would contribute his experience.
jesusfreak666er
16-07-2006, 23:05
how about valium? would that be able to be given rectally? Swim just procured 20mg valium and will give it a shot if someone gives him the thumbs up...
jesusfreak666er
17-07-2006, 00:30
very straight foward question, swim knows that valium isnt very water soluble but is slightly, so swim is wondering if one can administer valium rectally like xanax?
Forthesevenlakes
17-07-2006, 09:33
it would probably slightly work, and be more than slightly uncomfortable.
as an aside, and not a jab at swijf, but why are there so many recent posts about rectal benzos? did i not get the memo that this was now the cool thing to do?
Micklemouse
17-07-2006, 10:24
Yes it does work, & is used therapeutically for treatment of status eplecticus. How 'recreational' it is I couldn't say, although plugging seems to be an undignified but effective method for many things...
jesusfreak666er
18-07-2006, 00:32
swim tried 20mg rectally yesterday and was ehh, not impressed. it came on faster but all in all thought it was just as good as eating a pill.
Sklander
25-09-2006, 03:43
SWIM doesn't think that Alprazolam (Xanax) is water-soluble. SWIM thinks that mixing the crushed pills with lemon juice might work better to absorb the pill better and not create a paste, thus making the concoction of benzo liquid easier to administer to one's anal cavity.
"Natural Alprazolam is a white crystalline powder, soluble in alcohol, chloroform, sparingly soluble in acetone, slightly soluble in ethyl acetate and virtually not soluble in water at normal pH levels." - http://www.alprazolam.cc/generic-xanax-pharmacology.htm
Forthesevenlakes
25-09-2006, 19:30
How about dissolving a benzo in polyethylene glycol? That might work. Dont know how well the anal cavity would handle it, SWIM doesnt know if its painful or not, but it might be a better idea than dissolving in lemon juice.
Can anyone confirm if this would work? Its just an idea of SWIMs and not a suggestion that anyone go try this without confirmation of its safety/efficacy.
Polyethylene glycol is used for some iv preparations of benzos.
SWIJ would guess that if it's ok for your veins it's ok for your arse.
Sklander
25-09-2006, 20:14
Maybe a small amount of wine would do the trick?
^^^ SWIJ would worry about this one. The greater bioavailability of substances rectally would make the mixing of 2 downers even more likely to result in a reduced level of consciousness, inability to protect one's airway, and an increased risk of hypoxia.
Benzos + Alcohol = NOT recommended
Sklander
25-09-2006, 22:33
SWIM thinks that 5 - 10mL of wine would have a negligible effect on the alprazolam. SWIM is going to try this method sometime this week...
Nagognog2
26-09-2006, 00:06
With many years of practicing Yoga - one could do this with a straw. You'd be a real hit at a party.
Swim broke down and tried clonazepam rectally. The idea of using less was overpowering. I had to try it and had no bang at all , but 3mg. went all day. My second dose wasn't needed. My next experiment will be xanax ,when possible.
SWIM has also tried clonazepam rectally. It seems to take effect a little quicker and have a bit higher bioavailability, but that's about it. Could be its water-insoluble nature, although SWIM gets nearly zero effects from clonazepam no matter how he takes it (unless he takes 5+ mg or something... then he starts to really notice it). He's just been taking it for too long, most likely. His prescribed dose is 0.5mg twice/day, and he usually takes less than prescribed because it does so damn little for him.
P.S. one thing to try with benzos might be mixing some mineral oil in with the water the benzo is dissolved in. Benzos tend to be more soluble in oil than in water, so this might aid in absorption.
Sklander
05-10-2006, 05:50
SWIM has been experiementing with alprazolam rectally for the past few hours. He is having no trouble mixing it in a water solution then injecting with (with no needle) into his anus. The onset is quick and noticeably. In fact, he is about to administer another dose right now.
Alprazolam may not bond to the water molecules, but it will mix in enough so that you can have a swirly cloudy liquid that works just fine for rectal administration.
^^^ SWIJ would worry about this one. The greater bioavailability of substances rectally would make the mixing of 2 downers even more likely to result in a reduced level of consciousness, inability to protect one's airway, and an increased risk of hypoxia.
Although probably obvious, SWIM thinks it's worth mentioning... higher bioavailability (and maybe faster onset/longer duration) also likely corresponds to greater addictive potential. If it "feels like" twice as much, it's probably similar to taking twice as much orally.
Sklander
09-10-2006, 09:08
SWIM has been using H20 for mixing with his Alprazolam. It has worked surprisingly well.
SWIM mixes 2 - 4MG of Alprazolam with roughly 5 - 7CC's WARM water and mixes vigorously for about 20 seconds. The solution is mixed well enough to draw into a syringe. What SWIM usually does is draws the mixture up into the syringe several times to see if there are any leftover small chunks of Alprazolam left in his shot glass. After a proper and vigorous mixture, there should be good mixture between the chemical and the H20.
SWIM loads his syringe (which he bought from Walgreens for around $4.00 with the solution), lubes his anus with a bit of lotion or KY Jelly and inserts the syringe as far as possible into his rectum. He gets comfortable lying on his left side (since he is right handed) and proceeds to inject the solution into his rectum.
Onset is rapid and euphoric. Alprazolam is very bioavailibility via rectal administration and would recommend this route to anyone with an open mind.
SWIM injected 4MG Alprazolam into his rectum about four hours ago and is feeling the drowsing effects of sleep coming.
SWIM thought he just my share his experience with H20 because I know the topic was swaying towards what to mix the non-H20-soluble Alprazolam with.
Problem solved: mix it with water well and inject it quickly. SWIM promises you will see great results.
After doing some Google research recently, SWIM had the best luck so far increasing bioavailability of the cheap, crappy generic clonazepam tablets he's prescribed (which normally aren't too effective no matter what method of admin he's tried). This should work for alprazolam just as well.
(1) Measure out around 3ml of very warm water, drop tablet in and dissolve (well, melt... the drug itself isn't soluble in water).
(2) Add ~5-10% vegetable oil. Shake well to emulsify.
(3) Transfer liquid emulsion to rectal syringe. Shake a final time just before administration.
SWIM found the effects to be quite rapid and powerful using this method. Be careful with amounts used.
Sklander
25-10-2006, 03:48
The onset surprises most people. SWIM did another injection of 4MG xanax into his rectum using the simple crushing of the pill then mixing vigorously with water. SWIM didn't even think about using a bit of vegetable oil. Nice thought, SWINicaine, SWIM is going try this with 2MG more of alprazolam right now.
SWIM discovered something really fascinating about generic clonazepam (not sure if it applies to Xanax, but it may): Leaving the pills sitting in water overnight before injecting the solution rectally just about doubled the potency and speed of onset (vs. dissolving/plugging the pills in one step).
SWIM figures the explanation is this: It takes awhile for clonazepam (which is very water-insoluble) to separate from the pill binders, even though the pills ostensibly dissolve quickly. Before that happens absorption is apparently compromised via rectal admin, and quite likely sublingually as well... no wonder that method never worked well for SWIM. However, using vegetable oil (which clonazepam IS soluble in) does help... it's just not quite as effective as allowing the pills to sit in water overnight.
Anyway, SWIM is going to leave some tablets soaking in distilled water for purposes of future rectal admin. The results are much better (combining this with added vegetable oil may be the most effective of all). This has been a learning process, but it's gratifying to see what SWIM thought of as "sh*t sugar pills" become highly useful.
^^^ Yes SWInicaine, this added process greatly impoved SWIdr's clonazapam experience. SWIdr used 2mg of generic yellow WATSON clonazepam tablets, crushed them, and let them sit in 5mL for appro 24 hours. The experience (which SWIdr thought would be close to nothing, as he has a great tolerance because of daily Klonopin, Xanax, and Ativan use) was to his surprise, pretty good. SWIdr barely knows anything about chemistry, but is interested in trying this method with wine instead of water. SWIdr dosn't know weather the alcohol will ruin the clonazepam if left overnight, but it sounds like it could work. Any yes SWIdr is very experienced with mixing downers thru various ways of administration, and knows his limits, so no worries.
Sklander
15-11-2006, 01:10
SWIM believes the benzo powder you make from your crushed pills will mix with whatever alcohol is in the wine. You may need to just stir it a bit...
To SWIM's understand most benzo's (xanax, ativan, klonopin) are alcohol soluble.
To SWIM's understand most benzo's (xanax, ativan, klonopin) are alcohol soluble.
Generally more alcohol- than water-soluble, but many are still not that soluble in alcohol either.
Benzo solubility does vary... see this reference (one among many):
http://www.metrohealthanesthesia.com/edu/ivanes/benzos1.htm
^^^ Yes SWInicaine, this added process greatly impoved SWIdr's clonazapam experience. SWIdr used 2mg of generic yellow WATSON clonazepam tablets, crushed them, and let them sit in 5mL for appro 24 hours. The experience (which SWIdr thought would be close to nothing, as he has a great tolerance because of daily Klonopin, Xanax, and Ativan use) was to his surprise, pretty good.
SWIM found an even better technique: (1) Crush the pill to a powder, (2) Dissolve in a bit of 99% isopropyl alcohol or acetone... the latter seems to work better, (3) Evaporate completely, (4) Add water and administer rectally. Seems about as effective as it gets. Apparently acetone/alcohol completely separates the clonazepam from the pill binders. Rapid, full and potent effects (at last). SWIM thought he had a moderate tolerance, but 1mg almost knocked him out! :eek:
SWIM has arrived at this technique through trial and error, and in his opinion found the best/most potent effects with this one.
Benzodiazepines are, for the most part, very insoluble in water. Unbinding the drug from the crap they use to make pills seems to be a real trick, which is why snorting benzos doesn't work worth beans, sublingual only works somewhat and rectal admin also seems quite ineffective. Only after tossing around in stomach acids and a trip through the colon do benzos in pill form seem to work well.
SWIM suggests the following technique for plugging (rectal administration). You will need some acetone, which is available at many drugstores/apothecary shops as the pure stuff... don't use nail polish remover, which may contain fragrances and adulterants. If you absolutely can't get any, substitute 99% isopropyl alcohol.
(1) Crush the pill(s) thoroughly to a fine powder using a mortar/pestle or pill crusher. Put the pill(s) in some small container, preferably glass.
(2) Add some acetone. SWIM finds that around 10-20 drops per pill is about right. You can use too little, but not too much (more will just add to evaporation time). It should be a liquid, not a paste.
(3) Stir the mixture around really well. The acetone effectively unbinds the active drug from the pill constituents, or at least it's done so for everything SWIM's tested it so far.
(4) Evaporate the acetone completely. A hair dryer can be used cautiously. A tiny bit of acetone introduced into the body won't hurt you, so as long as you can no longer smell it at all it's probably done. The dried pill contents will be spread around on the bottom.
(5) Add enough hot water to plug (~4ml). Pluggers can use the water solution directly.
Here are some of SWIM's findings (so far):
* Generic clonazepam -- about triple the potency vs. just dissolving in water and plugging. Those horrid pills finally gave up the goods! So many wasted tablets to get there...
* Ambien (zolpidem) -- about 1.5 times more potent than just dissolving/plugging.
* Ativan (lorazepam) -- more water-soluble than most benzos. Improvement negligible, maybe 1.1 times more potent.
Please share experiences using this method, vs. other methods.
While SWIJ accepts SWINicaine's suggestions are suitable for plugging she does NOT accept that it is safe to use this method for preparing benzos for injection.
It is downright dangerous to advocate the use of any pill based material for iv injection, even with (very crude) extraction methods the risks are thrombosis, embolism and (potentially) death.
Sklander
26-12-2006, 03:36
SWIM has taken a lot of acid and he is fine. Actually, SWIM has grown quite a bit spiritually from taking large and small doses of LSD.
On topic, administering benzo's rectally is fairly easy. While they may not be water soluble in water SWIY can crush up a Xanax bar and mix it with a small amount of water and successfully inject it into the rectum... Shit... SWIM just did this not too long ago. There is nothing to it.
SWIM tends to use about four to five mL of water when he is mixing and make sure you crush up the pills as fine as possible.
SWIdr has mainly administered opiates rectally, but has administered many benzos and benzo-like substances. SWIdr just recently injected (without needle) 20 mg diazepam into his anal cavity, using mainly water with maybe 5% alcohol. He is feeling his valium veeerrryyy good right now. He usually takes his benzos orally with the grapefruit juice potentiation method, and this is just as good, if not better and faster. This rectal administration method isnt worth it with some benzos, but it is definatly worth it when it comes to most opiates and a few other benzos.
x cynic x
21-04-2007, 12:57
Though SWIM is unaware of how most benzos fair up the ass, he has found something on Midazolam.
Midazolam, the active ingredient of Hypnovel, is a derivative of the imidazobenzodiazepine group. The free base is a lipophilic substance with low solubility in water. The basic nitrogen in position 2 of the imidazobenzodiazepine ring system enables the active ingredient of Hypnovel to form water-soluble salts with acids. These produce a stable and well tolerated injection solution.
The pharmacological action of midazolam is characterized by rapid onset and, because of rapid metabolic transformation, short duration. Because of its low toxicity, midazolam has a wide therapeutic range.
Hypnovel has a very rapid sedative and sleep-inducing effect of pronounced intensity. It also exerts an anxiolytic, an anticonvulsant and a muscle-relaxant effect.
After i.m. or i.v. administration anterograde amnesia of short duration occurs (the patient does not recall events that occurred during the peak of activity of the compound).
Pharmacokinetics
Absorption
Absorption after i.m. injection
Absorption of midazolam from the muscle tissue is rapid and complete. Maximum plasma concentrations are reached within 30 minutes. The absolute bioavailability after i.m. injection is over 90%.
Absorption after rectal administration
After rectal administration midazolam is absorbed quickly. Maximum plasma concentration is reached in about 30 minutes. The absolute bioavailability is about 50%.
Absorption after intranasal administration
Midazolam is absorbed quickly. Mean peak plasma concentrations are reached within 10.2 to 12.6 minutes. The bioavailability is between 55 and 57%.
Absorption after oral administration
Oral midazolam is absorbed rapidly from the gastrointestinal tract and undergoes extensive first-pass hepatic metabolism. Peak plasma concentrations are reached within 1 hour. Bioavailability is between 40 and 50%.
Distribution
When midazolam is injected i.v., the plasma concentration-time curve shows one or two distinct phases of distribution. The volume of distribution at steady state is 0.7-1.2 l/kg. 96-98% of midazolam is bound to plasma proteins. The major fraction of plasma protein binding is due to albumin. There is a slow and insignificant passage of midazolam into the cerebrospinal fluid. In humans, midazolam has been shown to cross the placenta slowly and to enter foetal circulation. Small quantities of midazolam are found in human milk.
Metabolism
Midazolam is almost entirely eliminated by biotransformation. Less than 1% of the dose is recovered in urine as the unchanged substance. Midazolam is hydroxylated by the cytochrome P450 3A4 isozyme. α-hydroxymidazolam is the major urinary and plasma metabolite. 60-80% of the dose is excreted in urine as glucuroconjugated α-hydroxymidazolam. Plasma concentrations of α-hydroxymidazolam are 12% those of the parent compound. The fraction of the dose extracted by the liver has been estimated to be 30-60%. The elimination half-life of the metabolite is shorter than 1 hour. α-hydroxymidazolam is pharmacologically active, but contributes only minimally (about 10%) to the effects of intravenous midazolam. There is no evidence of a genetic polymorphism in the oxidative metabolism of midazolam (see Interactions).
http://www.medsafe.govt.nz/Profs/Datasheet/h/Hypnovelinj.htm
SWIM had previously tried rectally administering ativan and diazepam after mixing with water and wasn't too impressed.
Recently SWIM thouroughly mixed diazepam with an oil (propylene glycol) and alcohol (80% grain liquor) and then filtered out the binders etc from the pills.
SWIM was very impressed in the difference. Not an expert, but SWIM assumes the extra solubility and removing the binders would make for much better absorbtion.
Care to comment ?
FYI SWIM was doing this to research IM injections. See here if interested:
See this post if interested: http://www.drugs-forum.com/forum/showpost.php?p=268074&postcount=48
^^^ Yes. Neither Diazepam nor Lorazepam are very soluble in water. Diazepam IS soluble in propylene glycol (which is what valium ampoules for iv injection are mixed with).
Sklander
20-07-2007, 21:44
Diazepam is so not soluble in water it is ridiculous. H2O and Diazepam just don't mix. Period.
SWIM's buddy used a little Corona in his syringe for a rectal injection and it seemed to work a lot better. He said as he injected it into his ass he could taste the Corona... kind of like when you bang Cocaine and you get that taste in your mouth of Cocaine. SWIM thought it was quite interesting.
upperdecker
25-10-2007, 01:16
SWIM put this in another thread with no response, maybe he'll get one here. SWIM wants to know what would happen if one were to just plug the pills whole, not crushing them and mixing them with water and inserting with a beater (whatever its called). What would happen if SWIY would put the pills up your anus whole?
killagorilla187
14-12-2007, 16:58
What kind of product do you need to administer anything rectally, please advise swim. What Im thinking or seen are these big things that look like turkey basters. Those would seem useless and waseful since there so big.
Please post link or tell swim what to get. thanks
Micklemouse
14-12-2007, 17:49
Probably been mentioned before, but a syringe barrel (the bit with the plunger, not the needle!) would be the preferred utensil, possibly with a bit of lubricant applied. As ever, for hygiene's sake one hit only, & no sharing!
killagorilla187
14-12-2007, 18:49
Do they sell things like this at local stores? How long should barrel be aswell?
Mucho thanks
0utrider
05-04-2008, 19:25
if swim wouldnt have any isop. on hands, could he use vodka, just a tiny bit, and let the whole thing sit over night (as decribed) for usage? or does it necessarily have to be evaporated? he is thinking about just a few drops of vodka together with some warm water and letting it sit over night
(he things of using "prazepam" where can't find solubility infos to, but it is often said to be a (bad) alternative to alpralozam)
Sklander
29-04-2008, 17:15
BAH!!!
Don't suggest stupid things on this board. This is not the place.
SWIY shouldn't stick a pill in SWIY's ass. SWIY must break the pill up and mix it with some kind of liquid.
darkbreed
28-05-2008, 22:40
SWIM just took two pills last night and stuck'em up his butter. One was 15mg midazolam, the other one was 2mg alprazolam. He has never tried this route before with anything, and he knew he should crushed them up and mixed with water and shot it in with a syringe or so, but as he did not have such things available nor any other good replacements he could think of to get it in there he decided to just shove the pills themselves in, remembering that they do that in hospitals as a friend of his once got some anal codeine pill which he enjoyed.
In any case, it did work, and the effects did come on quicker than they would when swallowing them. SWIM is a little unsure about how they will absorb and dissolve in there though, considering it didn't exactly seem to be very vet there to put it like that. Anyone can explain this part? Meaning, how exactly do they dissolve and how long does it take for them to be completely dissolved and absorbed?
Now it is the day after, and SWIM have to go poop. He is a bit worried that the pills will come back out though perhaps in smaller pieces than when originally put inside =)
SWIM will go to the pharmacy after the toilet visit and buy a syringe and perhaps a needle or two as well considering he got plenty of midazolam which is easily soluble in water and people have reported nice effects when IV'ing, and he will also get some coke, and would like to check the difference between oral, anal and IV administration of these substances.
This time though he will crush he pills up first and mix them with water and use the syringe to pump it in to the back door with instead of just slamming in the whole pills.
darkbreed added 25 Minutes and 43 Seconds later...
Well swims fear about the toilet thing came true =)
Out popped some white semi-dissolved remains of the pills first of all, they were no longer solid but not sure if it was remains of both pills or just one of them and in any case SWIM guess that is why he still feel "fine" today as it must been in there slowly dissolving and absorbing all night and day long (normally SWIM would have taken a benzo by now as it's already 6:30 in the evening and SWIM take benzos on a daily basis)
So I guess that means it can perhaps be useful for very long active benzo effect, but not so strong, if the pills are just shoved up whole.
RaverHippie
28-05-2008, 23:36
SWIM did this. Put one 5mg Diazepam up as far as his long fingers could muster. Checked in about 20 minutes and pill was dissolved. If you wanted the anatomical reason, along the anus are mucous membranes which secrete, you guessed it, mucus to aid for passage of....things. Anyways this same mucous allows things to dissolve, and are probably the exact same cells that are found in the nasal sinuses which allow for snorting.
darkbreed
30-05-2008, 07:10
Well last night SWIM tried another procedure, he crushed up 7.5mg midazolam along with 2mg alprazolam, mixed it well in hot water, sucked it up in a syringe , inserted the syringe as far as he could get it up his butter, then injected the solution. It was a 5ml syringe.
The effects came pretty quickly, and faster than when eaten and also seemed to be a bit different in effect. Somewhat more enjoyable.
Swim intends to try again now in a moment but this time with 15mg midazolam and 2mg Clonazepam, and a bit of alcohol as he read above that should help.
5ml seem to be a nice amount, no problems holding it in or anything, nothing coming back out, and no need to go to toilet until the day after.
darkbreed added 89 Minutes and 20 Seconds later...
Well there goes. SWIM just injected 5 ml solution of 15mg midazolam, 3mg clonazepam, in a mix of 2.5ml 35% alcohol and 2.5ml water. The crushed pills were first added in a cup where the alcohol and water were added, then stirred for some time until it was a white liquid, and sucked it all up in the syringe before going to the bathroom and plugging up.
SWIM feels the effects already coming on only around 5 minutes after.
wearestardust
26-06-2008, 07:26
Diazepam is so not soluble in water it is ridiculous. H2O and Diazepam just don't mix. Period.
SWIM's buddy used a little Corona in his syringe for a rectal injection and it seemed to work a lot better. He said as he injected it into his ass he could taste the Corona... kind of like when you bang Cocaine and you get that taste in your mouth of Cocaine. SWIM thought it was quite interesting.
Look, why all this talk about crushing pills and so on and so forth?
For twenty-five years anybody has been quite at liberty to ask their doctor to prescribe STESOLID RECTAL TUBES instead of diazepam tablets. Water-soluble, whatever. What th hell does it matter when as well as Rectal Tubes there have also been diazepam suppositories on the market for even longer? Does nobody bother to even read Formularies to see what is available? This complete thread, excuse my tone, has been an utter waste of time and space when all that was required was a note to the effect that anal diazepam is not uncommon.
NO. There are NO alprazolam anal preparations.
Stesolid tubes ensure that the diaz reaches just the right part of the arse to take advantage of the highest number of blood vessels, through which, via mucous membranes, it is absorbed readily.
And as I say, they are NOT UNCOMMON.
If folks would READ about the medicines they use then a lot of space devoted to nonsensical things could be saved and... Jeez, what is the problem with people who just don't take the time to read up on what is out there to be prescribed?
WAS
Sklander
27-06-2008, 06:38
Look, why all this talk about crushing pills and so on and so forth?
For twenty-five years anybody has been quite at liberty to ask their doctor to prescribe STESOLID RECTAL TUBES instead of diazepam tablets. Water-soluble, whatever. What th hell does it matter when as well as Rectal Tubes there have also been diazepam suppositories on the market for even longer? Does nobody bother to even read Formularies to see what is available? This complete thread, excuse my tone, has been an utter waste of time and space when all that was required was a note to the effect that anal diazepam is not uncommon.
NO. There are NO alprazolam anal preparations.
Stesolid tubes ensure that the diaz reaches just the right part of the arse to take advantage of the highest number of blood vessels, through which, via mucous membranes, it is absorbed readily.
And as I say, they are NOT UNCOMMON.
If folks would READ about the medicines they use then a lot of space devoted to nonsensical things could be saved and... Jeez, what is the problem with people who just don't take the time to read up on what is out there to be prescribed?
WAS
SWIM doesn't see his physician prescribing him rectal tubes just because SWIM wants to get high, and SWIM is not so sure how many rectal tube Diazepams he is gonna get for x amount of dollars from his buddy.
Please, be realistic. The thread was NOT a waste of time. Maybe it was a waste of time for you, but SWIM found it quite informative and useful.
wearestardust
28-06-2008, 01:51
SWIM doesn't see his physician prescribing him rectal tubes just because SWIM wants to get high, and SWIM is not so sure how many rectal tube Diazepams he is gonna get for x amount of dollars from his buddy.
Please, be realistic. The thread was NOT a waste of time. Maybe it was a waste of time for you, but SWIM found it quite informative and useful.
Hey, sorry, I was in a high state of anxiety myself when I wrote that.
But every word is true. Except that the thread is a waste. Of course it isn't. People do need to know things they haven't read before.
But why the first sentence? Are you going to tell your doctor you want suppositories or the Rectal Tubes because SWIY wants a good hard buzz from them? Of course not. You're going to go in there all innocent and say something along the lines of "My Aunt/Uncle/Friend also needs diazepam but they get it in such-and-such a form, not tablets. I wonder, since they tell me that it works far quicker and more effectively, whether you might consider prescribing me diazepam rectal tubes?" No need for SWIY or SWIWAS even, to mention that this particular method of administration does in fact produce a far greater BZD hit than the normal 10mg white or blue tablets. In SWIWAS' opinion, up the arse 10mg feels a lot more like 25mg. Like IV vials, 10mg/2ml, injected very slowly because of the huge risk of respiratory depression, also feel almost triple the strength of the tabs. BRASS IT OUT. BE NORMAL. A doctor doesn't know automatically that you are looking for a 'dunt'. The patient is merely looking for the most efficient way of quelling his/her severe panic syndrome.
No problems unless you have an arsehole of a doctor. There are legit online pharmacies who will, on receipt of the script, send them to you cheaper than almost any pharmacy on the street. Though I am not allowed to name them. Google. There's the answer.
Anyway excuse my mood that night. SWIM should have taken a couple or three Xanax before putting finger to keyboard.
WAS
brandi29
30-06-2008, 18:50
Butter gets valium vaginal 10mg compounded supp for rectally or vaginal use for pelvic floor dysfuction from a compounded pharmacy, but said oral use better than rectally. Studies show valium doesn't absorb well rectally.
at the risk of sounding dumb, can i just put the bar up there, or do i have to dissolve it in water first. I just put the bar up there so i would kind of like to know quickly!
amylbj added 4 Minutes and 45 Seconds later...
this may sound like a really stupid question, but can i just put the bar up there rectally or do i need to dissolve it in water first? Would like to know kind of quick cause i just did it with no water.
wearestardust
09-07-2008, 00:39
The rectal tubes are an item which comes with a sort of plunger system; the trick is to get the thing at the optimum depth of the anus, quite easily done since there is a kind of 'bump' which is supposed to rest upon the actual anal entrance whilst the administration is made. Easy, and despite what one or two posters have said, extremely effective. Solubility in water is not an issue since it is absorbed through mucous membranes straight into the blood vessels.
WAS
rectal tubes? again, swim doesn't want to sound ike an idiot, but what are ther and where does swim get them?
darkbreed
10-07-2008, 08:59
I think the only way to get rectal administration is in hospitals or when you have some serious problems like throat cancer that makes it hard to swallow pills. I might be wrong but that's what I've gained so far at least. I never had a doc prescribe me anything rectally.
wearestardust
10-07-2008, 23:55
I think the only way to get rectal administration is in hospitals or when you have some serious problems like throat cancer that makes it hard to swallow pills. I might be wrong but that's what I've gained so far at least. I never had a doc prescribe me anything rectally.
Nah, Stesolid brand rectal tubes are available on prescription in most countries. Stesolid tablets, which have a reputation as being one of the finest brands of diazepam, are a lot more difficult to get hold of, being prescribed mostly in the Scandinavian countries and not available at all in the UK.
No need for a Hospital unless there is a section in your particular drug legislation confining its use to such a theatre.
As a MoI, MIDAZOLAM is only available in the United Kingdom in Hospital setting, and only in an injectable form. All Flormidal and Dormicum tablets must be imported privately, since they are non-prescribable on the NHS.
We are definitely Stardust.
ok, so swim decided to do this with 1mg of clonazepam. swim broke up the pill a little bit. but as soon as he put it in water, it started to dissolve quickly. swim kept shaking it and stuff. anyways. swim used an ear dropper he bought a while ago exactly for this purpose. but he thinks at that time he was planning on doing it with MDMA. never got around to doing that. so to get to the point. it worked. it feels like he took more then 1mg. clonazepam with him is kinda boring. if he takes too much, swim can't really walk straight. no euphoria or body high. that's why he's into opiates. but it feels like he did 2 or 3mgs. and he's calmer then before. so yay!
xxxSuSHixxx
12-09-2008, 06:54
Swipf says "Swipf wrote about this in another post, OBVIOUSLY in the wrong section, his mistake, but for him 4mg kpin in 25ml water was VERY effective, wishes he would have added alchohol too, swipf held the mix in for 1 hour, and basicly it all absorbed, had a bit of loose stool a while after but was nothing to complain about, being he couldent even walk strait and passed out on the floor ((a hard wood floor)) and remembers nothing of the night, i really wish swipf had posted the other one in this thread, drats and appologies, but YES rectal is GREAT. Here is the other post for those who missed it."
xxxSuSHixxx added 0 Minutes and 24 Seconds later...
re: Clonazepam Recreational Use SwiPF just did this..... let 4mg klonopin dissolve in about 25ml ((5 tsp?)) of warm water, they dissolved quick with a bit of stirring, used a 5ml syringe, took 5 times to get all the water in, was easy as pie, not painful at all, awaiting effects, hoping its not just a drowzy waste like usual, wonder if a stimulant would be good to avoid the drowze,
will post again if swipfs effects begin to be noticable.... wish swim luck!!! BTW, this is swipfs first rectal admin of a substance on purpose for recreational purposes, one small step for fish, one giant leap for fish kind. time is 9:31 pm, has been about 5 min, anyhoo... will post again about result, i can thank all of sWiYous for convincing swipf to stick a funny tube up his ass XD hooray for sticking things in asses!
Manbearpig would make some really odd spam wouldent it? pork cutlet fleshy gamey bear burger anyone?
xxxSuSHixxx added 1 Minutes and 25 Seconds later...
Oh, swipf was wondering if the alchohol makes a diff in rectal admin, swipf dident use any this time but would be happy to try, is this... rubbing alchohol? or everclear? ((mwuahahah in my state everclear is of a plenty))
xxxSuSHixxx added 24 Minutes and 4 Seconds later...
there is no way swipf mistook recreational for rectal, however this may be in the wrong section, its 9:59, walking to the store,, 1 block away... going to spend 1$ on the keno machine and move around a bit, swipf would kill for a certain herb for this journy but alas, its expensive and scarce here. feeling very small effects so far. will post soon.........
xxxSuSHixxx added 22 Minutes and 6 Seconds later...
Alas the keno machine was broken... although swipf lost his dollar on a scratchy instead, feeling kinda mellow......actually kinda relaxed... may drop a few under the tongue after a bit... but the question... is rectal admin any better than other methods? yet to be determined....time is 10:22
xxxSuSHixxx added 10 Minutes and 11 Seconds later...
10:31pm, SwiPF is feeling pretty inebriated, humf... its quite nice really.
xxxSuSHixxx added 27 Minutes and 48 Seconds later...
on a side note: almost if not all the water absorbed, was expecting to crap out a bunch of liquid ((pardon how it sounds, but yep, its rectal, no other way to say what needs to be said! left it sit in there for almost an hour before trying to let it escape, you have no idea how funny it sounds to have SwiPF be posting on this topic, he cant keep a strait face, quite funny)) anyhoo, i am about 60-75% content with SwiPF's rectal experiment, it is totally suggested for swiAnyone to try, it's alot smoother and less complicated than it sounds, so dont be affraid, just stick it in SwiYour ass!
could it be theoreticly safer than eating the pills i wonder? or maybe the binders absorb into the anal cavity also... humf and humf... VERY calm now, even with a screaming baby screaming like screaming babies do... Experiment Success!!
xxxSuSHixxx added 6 Minutes and 42 Seconds later...
Also to add to this endless ramble of ass candy, SwiPF is drinking a mountain dew amp to combat the drowze, sad the amp is probably worse for you than the kpin...
also if this is indeed in the wrong section, feel free to move it ((and sorry if that troubles Swianyone to a large extent)), SwiAnyone needs to read these kind of posts before waltzing off into the realm of ... whatever something.
SwiPF
xxxSuSHixxx added 106 Minutes and 55 Seconds later...
around 12:42 2mg kpin was dissolved under tongue, and one rolly cigerete was laced with a very little ammount of kpin powder, ((yes i know this is pointless)), anyhow, SwiPF's GF say he is very calm and mellow. No euphoria so to speak but... just.. feel "ok" which is not normal for SwiPF. This is a bit off topic BUT its related to the previous post so SwiPF thought it to be alright. Swipf really hopes he is doing ok with the rules of DF.
xxxSuSHixxx added 48 Minutes and 45 Seconds later...
Definatley swim feels something... 1:42am
xxxSuSHixxx added 3 Minutes and 35 Seconds later...
i hope that helped someone, Swipf really wants to contribute to the site in a way that helps people, sorry he has been a spaz posting retarded one liners, it wont happen anymore. so to stay on topic, rectal is great, and would be suggested to even his mother. cheers.
RaverHippie
13-09-2008, 15:23
SWIM did this. Put one 5mg Diazepam up as far as his long fingers could muster. Checked in about 20 minutes and pill was dissolved. If you wanted the anatomical reason, along the anus are mucous membranes which secrete, you guessed it, mucus to aid for passage of....things. Anyways this same mucous allows things to dissolve, and are probably the exact same cells that are found in the nasal sinuses which allow for snorting.
I forgot to update on this rambling. I saw a strange note in the gutter while it was raining yesterday. It told me to write in this thread saying
"5mg diazepam inserted rectally as described above had absolutely no effect as could be conjectured from the information gathered in this thread and the person attempted the 5mg dose rectally should have researched it better"
abortive
23-09-2008, 19:11
so a naked pill won't work as much as a shot with a rig? if so, fuck that...
lorazepam was decent, as was percs and lsd. but the thought of a rig instead of the actual original material is kinda messed up, if not worthwhile.
RaverHippie
24-09-2008, 01:29
This is just a recommendation for another method of administration. There's no need to offer unnecessary negative remarks on a thread which exists purely for informational purposes. Also if attempting be sure the specific benzodiazepine is water soluble as some aren't.
abortive
24-09-2008, 06:01
i didn't mean to be negative. as i said after that certain admins would be kinda messed up, yet ultimately worthwhile. i also implied i have used benzos, percs and lsd in that way with just the naked form, no rig.
what about clonazepam? everytime i try to get one in a rig it clogs/jams...
i dunno, one member says the admin works fine, others say it don't.
abortive added 1 Minutes and 4 Seconds later...
SUNK can't figure out how to edit his posts.
abortive added 1 Minutes and 49 Seconds later...
SUNK didn't mean to be negative. as he said after that certain admins would be kinda messed up, yet ultimately worthwhile. SUNK also implied he'd have used benzos, percs and lsd in that way with just the naked form, no rig.
what about clonazepam? everytime SUNK try to get one in a rig it clogs/jams...
SUNK dunno about others experiences and methods...
abortive added 1 Minutes and 4 Seconds later...
SUNK can't figure out how to edit his posts.
abortive added 121 Minutes and 21 Seconds later...
SUNK took a naked 2mg up there and is pretty loosened up and feelin aight.
after taking 8mgs yesterday with the usual 30 minute drunk effect mixed with a couple energy drinks, SUNK's opinion rectal would be a good alternative in case you're runnin low. but it's nothing SUNK would do on a regular basis...
Just for the method my mystic moggy used...
She crushed the footballs/blue bettys. Set them in a mix of wine and water. Used an enima.. emptyed the saline. Let the bettys sit for a while stirring occasionally, the fill and emptyed far up rectum. Results were instantanous and someting to be treated with caution. 2mg with wine is plenty. -Dunn. :vibes:
fiveleggedrat
21-10-2008, 00:11
Swim has become accustomed to rectal use after using hydromorphone in this way to potentiate it, which worked VERY well.
Swim's going to take 2mg lorazepam, and dissolve in a, oh, say 10% ethanol solution for better/faster absorption, after "cleaning" the admin site very well, which makes a BIG difference. Usually, 2mg would provide a buzz. 4mg is blackout, while 2 1/2-3 1/2 depending on random biological factors, is usually the sweet spot. All in all, lorazepam sucks vs. other benzos, even with alcohol OR opioids.
Avoiding first pass metabolism has to give the lorazepam some more "oomph" to it. Hoping this 2mg will go decently far, Swim needs to be able to sleep and relax, being out of pot, his lovely crutch.
Swim'll be back later ;)
KaLiShNiKoF
12-12-2008, 21:23
can you stick it in whole? or break it into little pieces? just wondering.. seems like a lot a trouble to go through just for maybe no different feeling at all...
KaLiShNiKoF added 40 Minutes and 24 Seconds later...
never mind, just tried it, used one of the old syringes, broke the needle off and cut off some of the rest with scissors. i dissolved 1mg alprazolam Xanax at first and tried it, went it well and nothing spilled, so i decided to take my last 1mg and dissolved it in hot water again and shook it up in the syringe, and took another. this was about 10 minutes ago at about 11:35am, we'll see how it comes on. i'll keep posted.
KaLiShNiKoF added 91 Minutes and 9 Seconds later...
much cleaner high, 2mg dose alprazolam, wish i had more. :(
phatassone
08-01-2009, 13:49
rectal administration of benzos is useless Unless you really like shoving things up ur butt, the oral bio-availablility of most benzos is so high any other ROA is pointless IMO
Just prepared a 2mg clonazerpam, 3 ml vodka and 10 ml water solution. I will let it sit over night, plug it tommorow morning and post results
xanned added 699 Minutes and 46 Seconds later...
Just plugged the solution...stung my shadow's ass a little but god damn, i have never felt clonazepam with such a quick onset and such potent effects!
(Two 1mg tablets, 7ml water, 3ml vodka, let dissolve OVERNIGHT in an airtight vial and ass it for breakfast)
ComfortablyNumb
20-01-2009, 22:55
SWIM just shoved a valium pill up his shaft, he told me he wished he just swallowed it. Its been 20 mins, should he feel anything yet?
newlevel
09-02-2009, 05:58
yes, well said. thank you
RaverHippie
09-02-2009, 08:09
Don't force chinchi to attempt this for the sake of reporting back the results. and also to get a real unbiased report it may be good to hold off on the alcohol until the benzo's effects have set in, just to be sure that the method of administration is behind any changes to the effect of the diazepam.
newlevel
10-02-2009, 06:13
yes, well said. thank you
ganja4girl20
02-03-2009, 03:37
swim tried alprazolam anally the first time today. swim was hesitant but it actually works! dont know if the buzz is any better, but it did hit much quicker than usual. swim just used water, next time swim will try with alcohol but doesnt know how. any suggestions?
newlevel
08-03-2009, 01:02
yes, well said. thank you
newlevel
26-03-2009, 00:40
did s
yes, well said. thank you
mbarnes0
30-03-2009, 06:37
did swianyone else try this and agree with swim that it sucked? swim was terribly disappointed. his lizard's ass just couldn't keep it in. very frustrating for swim's lizard...
SWIM knows for a fact that rectal administration works, he has just never used it for benzos. SWIM would say your lizard doesn't have the syringe in there far enough. SWIM uses a 10ml oral syringe from the local drug store and sticks it in at least to the 7.5ml line. They say that SWIY needs to put it "at least 2 knuckles in". SWIM has never had a problem keeping in 10ml of liquid or even up to 30ml for that matter. Once SWIY gets above 10ml though, SWIM thinks it does get a bit uncomfortable for about 5 minutes just trying to to shit it out.
Some swimmer please correct me if SWIM is wrong...
So benzos for the most part are pretty insoluble in water, which is why snorting is a waste. Crushing them down and mixing with water won't release hardly any of the goods into the water, but the water makes it possible to get your dose up in there and it gets absorbed through the rectal walls?
SWIM guesses he is confused on the part where they aren't water soluble but he always just used water to plug anything he has done so far, which has only been opiates.
Stimulants
06-04-2009, 09:13
Pre-dissolved simply hastens absorption,but water or solvent soluble shouldn't make a difference in suitability for pr.
It's well known that Tylenol is not water soluble, however it works as a pain reliever administered pr.
The amount of alprazolam we're talking about is single digit mg, so even if it's sparingly soluble in water, a 250ml of water should be more than enough to be a carrier.
FYI, alprazolam is highly soluble in chloroform, somewhat soluble in 95% ethanol and methanol, very slightly soluble in water and soluble in dilute nitric acid.
swim knows that there are special 10mg Diazepam suppositories in case that swiy would have an epileptic seizure or even not. swim could imagine, it would be like expidet pills for sublingual usage. In swims opinion it is very disgusting to push benzos in swiys anus.
PsychoActivist
20-04-2009, 08:47
Swipa was always under the impression that Benzo's are not absorbed well through the music membranes. Which to him it seems that plugging them would be almost the same as snorting them, as both methods take to the mucrose membrances. Most Benzo's are not water soluble.
This is just waht I have read and understood.
I could be wrong, but can I challenge any of you to help find some reputable resources or these posts?
It is our job here within this community to provide accurate information as well a harm reduction.
Again, I am not saying anyone is particularly wrong here. I would just like to seee some solid proof here.
Thank you and be safe
~PA~
Stimulants
20-04-2009, 21:51
Swipa was always under the impression that Benzo's are not absorbed well through the music membranes. Which to him it seems that plugging them would be almost the same as snorting them, as both methods take to the mucrose membrances. Most Benzo's are not water soluble.
One would find that a lot of pills are made with non-water soluble active ingredients.
This is just waht I have read and understood.
I could be wrong, but can I challenge any of you to help find some reputable resources or these posts?
It is our job here within this community to provide accurate information as well a harm reduction.
Again, I am not saying anyone is particularly wrong here. I would just like to seee some solid proof here.
Thank you and be safe
~PA~This applies to and only to diazepam, but here is a research based findings:
Def: po = oral, pr = plug
Pharmaceuticals:
Roche Valium IV
Roche Valium 10mg pill
Roche Valium PR
privately made PR
Subject: 6 volunteers
No statistically significant differences in po/pr in peak serum conc. or time to peak
n=6
mean po 76%, STD 16.8%
mean pr 81%, STD 13.0%
bioavailabiltiy was concluded to be similar for PR and PO for diazepam.
SWIM finds that the number of volunteers was not great enough (6 patients) to be conclusive, but based on these limited findings, there's no reason to do p.r. in place of p.o. since there's really no conclusive gain.
Source:
Article ID 1402110 from PubMed on US National Institute of Health site.
Br J Clin Pharmacol. 1982 March; 13(3): 427–432.
PMCID: PMC1402110
(http://www.pubmedcentral.nih.gov/about/copyright.html) Bioavailability of diazepam after intravenous, oral and rectal administration in adult epileptic patients.
S Dhillon, J Oxley, and A Richens